Tissue growth pressure drives early blood flow in the chicken yolk sac

Clément, Raphaël; Mauroy, Benjamin; Cornelissen, Annemiek J. M.

doi:10.1002/dvdy.24516

Cited by 7 publications

(7 citation statements)

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“…This effect will certainly also depend on metabolic and biochemical stimuli. In a recent article, Clément et al 35 showed that the metabolic activity of the yolk-sac, via cell developmental pressure, explains the radial expansion and the morphogenesis of the first circular peripheral vein. The results presented here show the existence of micro-domains of swollen tissue at much smaller scale, and even at single-cell scale, that contribute to positioning each venule between the associated arterial horseshoe.…”

Section: Discussionmentioning

confidence: 99%

“…These micro-domains are correlated to flat arterioles that adhere to the ectoderm. They are analogous to the early yolk-sac 35 , in that they correspond to domains that are locally ill-perfused. We have also observed that, in the same samples, and at the same developmental stage, there is a gradient of plexus anastomoses when going from the part of the CAM which is on top of the yolk towards the part of the CAM which is on top of the albumin.…”

Section: Discussionmentioning

confidence: 99%

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Direct imaging of capillaries reveals the mechanism of arteriovenous interlacing in the chick chorioallantoic membrane

et al. 2018

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Understanding vascular development in vertebrates is an important scientific endeavor. Normal vasculatures generally start off as a disorganized capillary lattice which progressively matures into a well-organized vascular loop comprising a hierarchy of arteries and veins. One striking feature of vascular development is the interlacing of arteries and veins. How arteries and veins manage to avoid themselves and interlace with such a perfect architecture is not understood. Here we present a detailed view of the development of the vasculature in the chorioallantoic membrane of the chicken embryo. We find that the origin of arteriovenous interlacing lies in the presence of an increased hemodynamic resistance at the distal part of the arteries due to vascular flattening onto the ectodermal surface. This reduces the vascular conductance distally, thus repelling veins away. In more proximal parts, vessels round off into cylinders and the increased flow attracts veins.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Direct imaging of capillaries reveals the mechanism of arteriovenous interlacing in the chick chorioallantoic membrane

et al. 2018

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Section: Vascularity and Cardiac Perfusionmentioning

confidence: 99%

“…Considerable interest has been directed to the role of the early circulation of the vertebrate embryo [96][97][98][99][100][101]. Early studies in zebrafish larvae suggested that the primary role of the circulation was in stimulating angiogenesis, although more recent studies have challenged this notion, suggesting that, in hypoxia or when active, the circulation is indeed involved in internal convection necessary for gas exchange [98].…”

Section: Vascularity and Cardiac Perfusionmentioning

confidence: 99%

Angiogenesis in the Avian Embryo Chorioallantoic Membrane: A Perspective on Research Trends and a Case Study on Toxicant Vascular Effects

Burggren

Antich

2020

JCDD

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The chorioallantoic membrane (CAM) of the avian embryo is an intrinsically interesting gas exchange and osmoregulation organ. Beyond study by comparative biologists, however, the CAM vascular bed has been the focus of translational studies by cardiovascular life scientists interested in the CAM as a model for probing angiogenesis, heart development, and physiological functions. In this perspective article, we consider areas of cardiovascular research that have benefited from studies of the CAM, including the themes of investigation of the CAM’s hemodynamic influence on heart and central vessel development, use of the CAM as a model vascular bed for studying angiogenesis, and the CAM as an assay tool. A case study on CAM vascularization effects of very low doses of crude oil as a toxicant is also presented that embraces some of these themes, showing the induction of subtle changes in the pattern of the CAM vasculature growth that are not readily observed by standard vascular assessment methodologies. We conclude by raising several questions in the area of CAM research, including the following: (1) Do changes in patterns of CAM growth, as opposed to absolute CAM growth, have biological significance?; (2) How does the relative amount of CAM vascularization compared to the embryo per se change during development?; and (3) Is the CAM actually representative of the mammalian systemic vascular beds that it is presumed to model?

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“…which have different frames of application [4,11]. In (36), x → K(x) takes values in the set of symmetric positive matrices.…”

Section: Reinterpretation Of the Unknownsmentioning

confidence: 99%

Modeling and analysis of adipocytes dynamic with a differentiation process

et al. 2020

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We propose in this article a model describing the dynamic of a system of adipocytes, structured by their sizes. This model takes into account the differentiation of a population of mesenchymal cells into preadipocytes and of preadipocytes into adipocytes; the differentiation rates depend on the mean adipocyte radius. The considered equations are therefore ordinary differential equations, coupled with an advection equation, the growth rate of which depends on food availability and on the total surface of adipocytes. Since this velocity is discontinuous, we need to introduce a convenient notion of solutions coming from Filippov theory. We are consequently able to determine the stationary solutions of the system, to prove the existence and uniqueness of solutions and to describe the asymptotic behavior of solutions in some simple cases. Finally, the parameters of the model are ﬁtted thanks to some experimental data and numerical simulations are displayed; a spatial extension of the model is studied numerically.

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Tissue growth pressure drives early blood flow in the chicken yolk sac

Abstract: This study shows that tissue growth pressure can drive early blood flow, and suggests that the mechanical environment, beyond hemodynamics, can contribute to vascular morphogenesis. Developmental Dynamics 246:573-584, 2017. © 2017 Wiley Periodicals, Inc.

Cited by 7 publications

References 35 publications

Direct imaging of capillaries reveals the mechanism of arteriovenous interlacing in the chick chorioallantoic membrane

Direct imaging of capillaries reveals the mechanism of arteriovenous interlacing in the chick chorioallantoic membrane

Angiogenesis in the Avian Embryo Chorioallantoic Membrane: A Perspective on Research Trends and a Case Study on Toxicant Vascular Effects

Modeling and analysis of adipocytes dynamic with a differentiation process

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