BSND is a Novel Immunohistochemical Marker for Oncocytic Salivary Gland Tumors

Shinmura, Kazuya; Kato, Hisami; Kawanishi, Yuichi; Kamo, Takaharu; Inoue, Yusuke; Yoshimura, Katsuhiro; Sugiyama, Kenta; Misawa, Kiyoshi; Hosokawa, Seiji; Mineta, Hiroyuki; Sugimura, Haruhiko

doi:10.1007/s12253-017-0248-9

Cited by 6 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Until recently, the only confirmed extra-renal site of ClC-K expression (and that of its ␤-subunit barttin) was the inner ear (FIGURE 9). Recent work detected barttin in basolateral membranes of salivary gland duct cells (774), strongly suggesting the presence of ClC-K/barttin channels also in this epithelium. In the inner ear, both ClC-K isoforms are expressed in basolateral membranes of K ϩ secreting epithelial cells, i.e., of the marginal cells in the cochlear stria vascularis (FIGURE 9) and of dark cells in the vestibular organ (222,422,699,725).…”

Section: B Localization Of Clc-k/barttin Channelsmentioning

confidence: 82%

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease

Jentsch

Pusch

2018

Physiological Reviews

345

421

View full text Add to dashboard Cite

CLC anion transporters are found in all phyla and form a gene family of eight members in mammals. Two CLC proteins, each of which completely contains an ion translocation parthway, assemble to homo- or heteromeric dimers that sometimes require accessory β-subunits for function. CLC proteins come in two flavors: anion channels and anion/proton exchangers. Structures of these two CLC protein classes are surprisingly similar. Extensive structure-function analysis identified residues involved in ion permeation, anion-proton coupling and gating and led to attractive biophysical models. In mammals, ClC-1, -2, -Ka/-Kb are plasma membrane Cl channels, whereas ClC-3 through ClC-7 are 2Cl/H-exchangers in endolysosomal membranes. Biological roles of CLCs were mostly studied in mammals, but also in plants and model organisms like yeast and Caenorhabditis elegans. CLC Cl channels have roles in the control of electrical excitability, extra- and intracellular ion homeostasis, and transepithelial transport, whereas anion/proton exchangers influence vesicular ion composition and impinge on endocytosis and lysosomal function. The surprisingly diverse roles of CLCs are highlighted by human and mouse disorders elicited by mutations in their genes. These pathologies include neurodegeneration, leukodystrophy, mental retardation, deafness, blindness, myotonia, hyperaldosteronism, renal salt loss, proteinuria, kidney stones, male infertility, and osteopetrosis. In this review, emphasis is laid on biophysical structure-function analysis and on the cell biological and organismal roles of mammalian CLCs and their role in disease.

show abstract

Section: B Localization Of Clc-k/barttin Channelsmentioning

confidence: 82%

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease

Jentsch

Pusch

2018

Physiological Reviews

345

421

View full text Add to dashboard Cite

show abstract

“…The Barkitt gene (associated with, e.g., sudden deafness) encodes essential beta subunit for CLC chlorine channels, a protein involved in chloride transport, and is expressed in normal kidney and the inner ear, and also known as an immunohistochemical marker for chromophobe renal cell carcinoma and renal oncocytoma. BSND has recently been found to be expressed in the striated duct cells of normal salivary glands and has 100% positivity in WT and OC, while total negativity was demonstrated in 11 PAs, 7 adenoid cystic carcinomas, 6 acinic cell carcinomas, 6 mucoepidermoid carcinomas and 5 salivary duct carcinomas [36]. The BSND antibody does not discriminate between oncocytic renal tumour cells, WT or OC, but positivity excludes other salivary tumours with oncocytic cell participation, for example mucoepidermoid carcinoma and PA.…”

Section: Oncocytomamentioning

confidence: 99%

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours

et al. 2019

View full text Add to dashboard Cite

Introduction: A vast increase in knowledge of numerous aspects of malignant salivary gland tumours has emerged during the last decade and, for several reasons, this has not been the case in benign epithelial salivary gland tumours. We have performed a literature review to investigate whether an accurate histological diagnosis of the 11 different types of benign epithelial salivary gland tumours is correlated to any differences in their clinical behaviour. Methods: A search was performed for histological classifications, recurrence rates and risks for malignant transformation, treatment modalities, and prognosis of these tumours. The search was performed primarily through PubMed, Google Scholar, and all versions of WHO classifications since 1972, as well as numerous textbooks on salivary gland tumours/head and neck/pathology/oncology. A large number of archival salivary tumours were also reviewed histologically. Results: Pleomorphic adenomas carry a considerable risk (5-15%) for malignant Henrik Hellquist and Antó nio Paiva-Correia contributed to the manuscript equally and are co-first authors.

show abstract