2017
DOI: 10.1007/s00213-017-4612-y
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Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system

Abstract: Our findings suggest that dopaminergic pathways and proBDNF signaling and TrkB receptors play different roles in social defeat-stressed mice exposed to cocaine.

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Cited by 46 publications
(32 citation statements)
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References 77 publications
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“…A recent study found that mice exhibited decreased levels of the transcription actors Pitx3 and Nurr1 in the VTA when they were defeated during adolescence, but not in adulthood. This confirms that the genetic control of DA markers is altered only when social stress occurs during adolescence (Montagud‐Romero et al., ). The molecular processes underlying the different effects of SD on transcriptional factors are difficult to determine.…”
Section: Mechanisms Underlying the Effects Of Social Defeat Stress Onsupporting
confidence: 78%
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“…A recent study found that mice exhibited decreased levels of the transcription actors Pitx3 and Nurr1 in the VTA when they were defeated during adolescence, but not in adulthood. This confirms that the genetic control of DA markers is altered only when social stress occurs during adolescence (Montagud‐Romero et al., ). The molecular processes underlying the different effects of SD on transcriptional factors are difficult to determine.…”
Section: Mechanisms Underlying the Effects Of Social Defeat Stress Onsupporting
confidence: 78%
“…Although adolescents display a higher release of adrenocorticotropic hormone (ACTH) and corticosterone in response to an acute stressor than adults (Bingham et al., ; Doremus‐Fitzwater, Varlinskaya, & Spear, ), their response to SD evolves with the repetition of the encounters. Adolescent mice experience the first SD as play‐fighting rather than social stress, as male aggression during this phase is not experienced in the same way as during maturity (Montagud‐Romero et al., ; Rodríguez‐Arias et al., ). With the repetition of the defeat experience and the maturation of their hormonal profile, adolescent animals exhibit higher corticosterone responses with respect to their first agonistic encounter, thus displaying an increasingly adult response (Romeo et al., ; Lui et al., ; Wright, Muir, & Perrot, ).…”
Section: Social Defeat Stress During Adolescencementioning
confidence: 99%
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“…(Xu et al, 2011;Benarroch, 2015;Borodinova and Salozhin, 2016). These opposite effects have been hypothesized specifically in the NAcc in the context of animal models of depression as learned helplessness and social defeat stress, where BDNF content is increased while proBDNF content is decreased compared to control animals in this brain area (Shirayama et al, 2015;Yang et al, 2016;Montagud-Romero et al, 2017). In this regard, since it is well-documented that an increase in BDNF content in the NAcc increases cocaine-seeking behavior and vulnerability to substance abuse (Krishnan et al, 2007;Burke and Miczek, 2015), an increase in proBDNF in this brain area could have an opposite impact.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, numerous studies have demonstrated that adolescent social defeat increases addictive-like phenotypes in male rodents. Specifically, increased conditioned place preference to cocaine and MDMA is seen following adolescent social defeat stress (Garcia-Pardo et al, 2015;Montagud-Romero et al, 2017). Similarly, both adolescent social defeat and social isolation increase cocaine self-administration in male rats (Burke and Miczek, 2015;Yajie et al, 2005).…”
Section: Adolescent Social Isolation Promotes Vulnerability To Addictmentioning
confidence: 99%