Osteosynthesis of partial rib osteotomy in a miniature pig model using human standard-sized magnesium plate/screw systems: Effect of cyclic deformation on implant integrity and bone healing

Schaller, Benoît; Saulačić, Nikola; Beck, Stefan; Imwinkelried, T.; Liu, Edwin Wei Yang; Nakahara, Ken; Hofstetter, Willy; Iizuka, Tetsuya

doi:10.1016/j.jcms.2017.03.018

Cited by 22 publications

(12 citation statements)

References 30 publications

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“…The recent research in the field of Mg and its alloys revolves around two main applications: vascular stents and orthopedics . The first successful implantation of a biodegradable Mg stent became possible in 2005 when it was implanted in treating a left pulmonary artery of a 6 week old baby .…”

Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

“…The study proved no harmful effect of Mg implants on bone formation and healing. The Mg plate/screw system exhibited good mechanical stability with only a few screws broke on 12th and 24th weeks . Figure shows the implanted plate/screws system in the ribs of the pig along with its schematic presentation.…”

Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

“…Figure shows the implanted plate/screws system in the ribs of the pig along with its schematic presentation. Figure also presents the histological sections of bone healing in osteotomized ribs after 24 weeks implantation of titanium, Mg 3 (PO 4 ) 2 coated Mg, and uncoated Mg . The effect of implant's degradation on the hardness of bones in the femur of rats was studied by comparing different Mg alloys with Ti alloy Ti–6Al–7Nb, polymeric PLGA, and a sample with a drilled hole in the bone.…”

Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

“…(c) Schematic diagram of plate i on the osteotomized seventh rib and plate j on the intact seventh rib. Screws i1, i3, i5, j1, j3, and j5 were selected for CT and histological analysis …”

Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

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The current trends of Mg alloys in biomedical applications—A review

2018

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Magnesium (Mg) has emerged as an ideal alternative to the permanent implant materials owing to its enhanced properties such as biodegradation, better mechanical strengths than polymeric biodegradable materials and biocompatibility. It has been under investigation as an implant material both in cardiovascular and orthopedic applications. The use of Mg as an implant material reduces the risk of long-term incompatible interaction of implant with tissues and eliminates the second surgical procedure to remove the implant, thus minimizes the complications. The hurdle in the extensive use of Mg implants is its fast degradation rate, which consequently reduces the mechanical strength to support the implant site. Alloy development, surface treatment, and design modification of implants are the routes that can lead to the improved corrosion resistance of Mg implants and extensive research is going on in all three directions. In this review, the recent trends in the alloying and surface treatment of Mg have been discussed in detail. Additionally, the recent progress in the use of computational models to analyze Mg bioimplants has been given special consideration.

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Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

“…(c) Schematic diagram of plate i on the osteotomized seventh rib and plate j on the intact seventh rib. Screws i1, i3, i5, j1, j3, and j5 were selected for CT and histological analysis …”

Section: Current Biomedical Applications Of Mgmentioning

confidence: 99%

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The current trends of Mg alloys in biomedical applications—A review

2018

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“…As a result, subcutaneous gas cavity formation was mainly observed with the uncoated plate, and the coated screw showed increased bone density and bone-implant contact, as well as a lower corrosion rate compared to the uncoated screw, and it was suggested that further research on Mg coating to prevent gas formation is needed for application in the facial skeleton [ 122 ]. In addition, studies on the application of Mg for osteosynthesis of cranioplasty in miniature pigs and osteosynthesis using Mg plates and screws in partial rib osteotomy of miniature pigs for the evaluation of cyclic deformation were also conducted, and suitable and promising results for internal fixation were reported [ 123 , 124 ]. As the most recent study using miniature pigs, Naujokat et al [ 125 ] used Mg alloys with surface modification via hydrogenation or fluoridation in the mandibular osteotomy model and compared them with Mg alloys without surface modification.…”

Section: New Bioabsorbable Plates and Screws—magnesium Plates And mentioning

confidence: 99%

Bioabsorbable Osteofixation Materials for Maxillofacial Bone Surgery: A Review on Polymers and Magnesium-Based Materials

Cho

Byun

et al. 2020

Biomedicines

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Clinical application of osteofixation materials is essential in performing maxillofacial surgeries requiring rigid fixation of bone such as trauma surgery, orthognathic surgery, and skeletal reconstruction. In addition to the use of titanium plates and screws, clinical applications and attempts using bioabsorbable materials for osteofixation surgery are increasing with demands to avoid secondary surgery for the removal of plates and screws. Synthetic polymeric plates and screws were developed, reaching satisfactory physical properties comparable to those made with titanium. Although these polymeric materials are actively used in clinical practice, there remain some limitations to be improved. Due to questionable physical strength and cumbersome molding procedures, interests in resorbable metal materials for osteofixation emerged. Magnesium (Mg) gained attention again in the last decade as a new metallic alternative, and numerous animal studies to evaluate the possibility of clinical application of Mg-based materials are being conducted. Thanks to these researches and studies, vascular application of Mg-based biomaterials was successful; however, further studies are required for the clinical application of Mg-based biomaterials for osteofixation, especially in the facial skeleton. The review provides an overview of bioabsorbable osteofixation materials in maxillofacial bone surgery from polymer to Mg.

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Biodegradable magnesium‐based biomaterials: An overview of challenges and opportunities

Amukarimi

Mozafari

2021

MedComm

106

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As promising biodegradable materials with nontoxic degradation products, magnesium (Mg) and its alloys have received more and more attention in the biomedical field very recently. Having excellent biocompatibility and unique mechanical properties, magnesium‐based alloys currently cover a broad range of applications in the biomedical field. The use of Mg‐based biomedical devices eliminates the need for biomaterial removal surgery after the healing process and reduces adverse effects induced by the implantation of permanent biomaterials. However, the high corrosion rate of Mg‐based implants leads to unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. To overcome these limitations, alloying Mg with suitable alloying elements and surface treatment come highly recommended. In this area, open questions remain on the behavior of Mg‐based biomaterials in the human body and the effects of different factors that have resulted in these challenges. In addition to that, many techniques are yet to be verified to turn these challenges into opportunities. Accordingly, this article aims to review major challenges and opportunities for Mg‐based biomaterials to minimize the challenges for the development of novel biomaterials made of Mg and its alloys.

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Osteosynthesis of partial rib osteotomy in a miniature pig model using human standard-sized magnesium plate/screw systems: Effect of cyclic deformation on implant integrity and bone healing

Cited by 22 publications

References 30 publications

The current trends of Mg alloys in biomedical applications—A review

The current trends of Mg alloys in biomedical applications—A review

Bioabsorbable Osteofixation Materials for Maxillofacial Bone Surgery: A Review on Polymers and Magnesium-Based Materials

Biodegradable magnesium‐based biomaterials: An overview of challenges and opportunities

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