Serum Magnesium and Related Factors in Long-Term Renal Transplant Recipients: An Observational Study

Rodrigues, Natacha; Santana, Alice; Guerra, J.; Neves, Marta; Nascimento, C.; Gonçalves, Jurema Ribeiro Luiz; Costa, António Gomes da

doi:10.1016/j.transproceed.2017.01.070

Cited by 11 publications

(8 citation statements)

References 10 publications

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“…In a cohort of 49 kidney transplant recipients, 22.4% of patients had hypomagnesemia 6 years after transplantation [ 31 ]. As observed in the general population, serum Mg levels were inversely correlated with glomerular filtration rate [ 32 ].…”

Section: Magnesium Status After Kidney Transplantation and Relatiomentioning

confidence: 87%

Serum Magnesium after Kidney Transplantation: A Systematic Review

et al. 2018

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Magnesium (Mg) status has recently drawn close attention in chronic kidney disease and in kidney transplant recipients. This review aims to evaluate the body of evidence linking hypomagnesemia to clinical consequences in these specific populations. After a brief summary of the main mechanisms involved in Mg regulation and of Mg status in end-stage renal disease, the review focuses on the relationship between hypomagnesemia and cardiovascular risk in kidney transplant recipients. A body of evidence in recent studies points to a negative impact of hypomagnesemia on post-transplant diabetes mellitus (PTDM) and cardiovascular risk, which currently represent the main threat for morbidity and mortality in kidney transplantation. Deleterious biological mechanisms induced by hypomagnesemia are also discussed. While data analysis enables us to conclude that hypomagnesemia is linked to the development of PTDM, studies prospectively evaluating the impact of hypomagnesemia correction after kidney transplantation are still lacking and needed.

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Section: Magnesium Status After Kidney Transplantation and Relatiomentioning

confidence: 87%

Serum Magnesium after Kidney Transplantation: A Systematic Review

et al. 2018

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“…( 28 ) found that the plasma Mg 2+ levels in liver transplant recipients with diabetes were lower before surgery and within the first month after surgery, confirming that hypomagnesemia is a risk factor for PTDM. CNIs can cause a decrease in plasma Mg 2+ levels, leading to hypomagnesemia ( 126 ). Hypomagnesemia is also a risk factor for PTDM, and its mechanism might be as follows: hypomagnesemia can reduce the activity of insulin tyrosine kinase, affect the synthesis and secretion of insulin, and cause hyperglycemia after transplantation.…”

Section: How Can the Incidence Of Ptdm Be Reduced?mentioning

confidence: 99%

Progress of new-onset diabetes after liver and kidney transplantation

et al. 2023

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Organ transplantation is currently the most effective treatment for end-stage organ failure. Post transplantation diabetes mellitus (PTDM) is a severe complication after organ transplantation that seriously affects the short-term and long-term survival of recipients. However, PTDM is often overlooked or poorly managed in its early stage. This article provides an overview of the incidence, and pathogenesis of and risk factors for PTDM, aiming to gain a deeper understanding of PTDM and improve the quality of life of recipients.

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“… 60 It appears that kidney function plays an important role regarding the hypomagnesemic effect of CNIs, given that serum Mg levels demonstrate a negative correlation with creatinine clearance. 61 , 62 CNIs cause inappropriate renal Mg loss, likely because they reduce the expression of TRPM6; a shift of Mg into cells may also contribute. 59 , 63 , 64 Even though CNI‐induced hypomagnesemia is usually mild, severe neurological symptoms have been reported, including altered mental status, seizures, or focal neurological deficits.…”

Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

“…For example, serum Mg concentrations were significantly lower in recipients of allogeneic hematopoietic stem cell transplantation who received tacrolimus compared with cyclosporine 60 . It appears that kidney function plays an important role regarding the hypomagnesemic effect of CNIs, given that serum Mg levels demonstrate a negative correlation with creatinine clearance 61,62 . CNIs cause inappropriate renal Mg loss, likely because they reduce the expression of TRPM6; a shift of Mg into cells may also contribute 59,63,64 .…”

Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

An overview of diagnosis and management of drug‐induced hypomagnesemia

Liamis

Hoorn

Florentin

et al. 2021

Pharmacology Res & Perspec

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Hypomagnesemia is usually defined as a serum magnesium (Mg) level below 0.65 mmol/L (1.3 mEq/L; 1.5 mg/dl). 1 Serum Mg exists in three forms: (1) free or ionized Mg, the physiologically active form that accounts for 55%-70% of total serum Mg; (2) Mg complexed to anions, including bicarbonates, sulfates, phosphates, and citrates (5%-15%) and (3) Mg bound to serum proteins (primarily albumin), constituting the remaining approximately 30%. 2 Similarly to hypocalcemia, hypoalbuminemia is also related to spurious hypomagnesemia. 3 Consequently, in hypoalbuminemic states (serum albumin <4 g/dl) corrected serum Mg should be calculated using the formula: corrected Mg (mmol/L) = measured Mg(mmol/L) + 0.005 × (40 − albumin g/L). 4 Correction of Mg for albumin levels is rarely performed in clinical practice, a strategy that should probably change.The incidence of hypomagnesemia varies considerably from merely 2% among individuals in the community up to as high as 65% in patients hospitalized in intensive care units. 5,6 Discrepancies in the reported incidences of hypomagnesemia are attributed to the fact that serum Mg is not routinely measured and that this ion is

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Serum Magnesium and Related Factors in Long-Term Renal Transplant Recipients: An Observational Study

Cited by 11 publications

References 10 publications

Serum Magnesium after Kidney Transplantation: A Systematic Review

Serum Magnesium after Kidney Transplantation: A Systematic Review

Progress of new-onset diabetes after liver and kidney transplantation

An overview of diagnosis and management of drug‐induced hypomagnesemia

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