Spatial and temporal patterns of nasopharyngeal carcinoma mortality in China, 1973–2005

Xia, Changfa; Yu, Xue Qin; Zheng, Rongshou; Zhang, Siwei; Zeng, Hongmei; Wang, Jinfeng; Liao, Yilan; Zou, Xin; Zuo, Tingting; Yang, Zhixun; Chen, Wanqing

doi:10.1016/j.canlet.2017.04.016

Cited by 11 publications

(10 citation statements)

References 25 publications

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“…The provincial level data were then aggregated into seven geographical regions. We used generalized linear models with a negative binomial error structure [to overcome over-dispersion (15)] to calculate rate ratio (RR) of death from cervical cancer for the aggregated data for geographical regions (with national average as a reference) after controlling for the other factors included in the model. A detailed description of the models can be found in our previous publications (16,17).…”

Section: Discussionmentioning

confidence: 99%

Trends in geographical disparities for cervical cancer mortality in China from 1973 to 2013: a subnational spatio-temporal study

Xia

Ding

Zheng

et al. 2017

Chinese Journal of Cancer Research

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Section: Discussionmentioning

confidence: 99%

Trends in geographical disparities for cervical cancer mortality in China from 1973 to 2013: a subnational spatio-temporal study

Xia

Ding

Zheng

et al. 2017

Chinese Journal of Cancer Research

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“…24 We derived estimates for Epstein-Barr virus (EBV) prevalence among cases of nasopharyngeal carcinoma from a meta-analysis stratified by epidemic areas (high, intermediate, and low mortality; appendix). 25 Except for HPV-related cervical cancer and EBV-related nasopharyngeal carcinoma, the provincial representative prevalence data for cancer related to HPV, EBV, and human herpesvirus-8 (HHV8) were not available (accounting for 0•92% of total attributable cancer deaths).…”

Section: Exposure Prevalence Datamentioning

confidence: 99%

Disparities by province, age, and sex in site-specific cancer burden attributable to 23 potentially modifiable risk factors in China: a comparative risk assessment

Chen

Xia

Zheng

et al. 2019

The Lancet Global Health

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Background Understanding disparities in the burden of cancer attributable to different risk factors is crucial to inform and improve cancer prevention and control. In this report, we estimate the site-specific population-attributable fractions (PAFs) for 23 potentially modifiable risk factors across all provinces in China. MethodsIn this comparative risk assessment study, we used 2014 cancer mortality data for adults from 978 countylevel surveillance points in 31 provinces of mainland China. Risk-factor prevalence estimates were obtained from representative surveys. We used summary relative risks obtained from several recent large-scale pooled analyses or high-quality meta-analyses of studies in China. We calculated PAFs using multiple formulae incorporating exposure prevalence and relative risk data stratified by age, sex and province and then combined to create summary PAFs by sex, cancer site, and risk factors. Findings About 1 036 004 cancer deaths (45•2% of all cancer deaths [95% CI 44•0-46•4]) in China in 2014 in adults aged 20 years or older were attributable to 23 evaluated risk factors. The PAF was higher in men (51•2% [95% CI 50•0-52•4]) than in women (34•9% [33•6-36•2]), with the leading risk factors being active smoking in men and low fruit intake in women. By province, the PAF in both sexes combined ranged from 35•2% in Shanghai to 52•9% in Heilongjiang, while the PAF varied from 40•9% in Shanghai to 56•4% in Guangdong among men and from 26•9% in Shanghai to 48•0% in Heilongjiang among women. The highest PAF among men was smoking in all 31 provinces, whereas among women it varied among low fruit intake (14 provinces), hepatitis B virus infection (seven provinces), smoking (six provinces), excess bodyweight (three provinces), and human papilloma virus infection (one province).Interpretation The PAFs of cancers attributable to potentially modifiable risk factors vary substantially across provinces in China. Regional adoption of effective primary cancer prevention strategies has a vast potential to reduce the burden of cancer and disparities in China. Smoking, poor diet, and infection warrant particular policy attention as they contributed a large proportion to the total cancer burden.

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“…Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck common in Asia, especially in southern China ( Xia et al, 2017 ). Radiotherapy (RT) is the treatment of choice for NPC ( Li et al, 2018 ), but RT may lead to the development of serious complications in the central nervous system, namely, radiation brain injury (RBI), which can be temporary and reversible or progressive and irreversible, with clinical manifestations ranging from mild fatigue to neurocognitive dysfunction and even death ( Stone and DeAngelis, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Topological Properties of Static/Dynamic Functional Networks and Cognitive Function After Radiotherapy for Nasopharyngeal Carcinoma Using Resting-State fMRI

et al. 2021

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ObjectivesThe purpose of this study was to (1) explore the changes in topological properties of static and dynamic brain functional networks after nasopharyngeal carcinoma (NPC) radiotherapy (RT) using rs-fMRI and graph theoretical analysis, (2) explore the correlation between cognitive function and changes in brain function, and (3) add to the understanding of the pathogenesis of radiation brain injury (RBI).MethodsFifty-four patients were divided into 3 groups according to time after RT: PT1 (0–6 months); PT2 (>6 to ≤12 months); and PT3 (>12 months). 29 normal controls (NCs) were included. The subjects’ topological properties were evaluated by graph-theoretic network analysis, the functional connectivity of static functional networks was calculated using network-based statistics, and the dynamic functional network matrix was subjected to cluster analysis. Finally, correlation analyses were conducted to explore the relationship between the altered network parameters and cognitive function.ResultsAssortativity, hierarchy, and network efficiency were significantly abnormal in the PT1 group compared with the NC or PT3 group. The small-world variance in the PT3 group was smaller than that in NCs. The Nodal ClustCoeff of Postcentral_R in the PT2 group was significantly smaller than that in PT3 and NC groups. Functional connectivities were significantly reduced in the patient groups. Most of the functional connectivities of the middle temporal gyrus (MTG) were shown to be significantly reduced in all three patient groups. Most of the functional connectivities of the insula showed significantly reduced in the PT1 and PT3 groups, and most of the functional connectivities in brain regions such as frontal and parietal lobes showed significantly reduced in the PT2 and PT3 groups. These abnormal functional connectivities were correlated with scores on multiple scales that primarily assessed memory, executive ability, and overall cognitive function. The frequency F of occurrence of various states in each subject differed significantly, and the interaction effect of group and state was significant.ConclusionThe disruption of static and dynamic functional network stability, reduced network efficiency and reduced functional connectivity may be potential biomarkers of RBI. Our findings may provide new insights into the pathogenesis of RBI from the perspective of functional networks.

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Spatial and temporal patterns of nasopharyngeal carcinoma mortality in China, 1973–2005

Cited by 11 publications

References 25 publications

Trends in geographical disparities for cervical cancer mortality in China from 1973 to 2013: a subnational spatio-temporal study

Trends in geographical disparities for cervical cancer mortality in China from 1973 to 2013: a subnational spatio-temporal study

Disparities by province, age, and sex in site-specific cancer burden attributable to 23 potentially modifiable risk factors in China: a comparative risk assessment

Altered Topological Properties of Static/Dynamic Functional Networks and Cognitive Function After Radiotherapy for Nasopharyngeal Carcinoma Using Resting-State fMRI

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