Sebaceous Carcinomas of the Skin: 24 Cases and a Literature Review

Haber, Richard M.; Battistella, Maxime; Pagès, Cécile; Bagot, Martine; Lebbe, Célèste; Basset-Séguin, Nicole

doi:10.2340/00015555-2685

Cited by 9 publications

(3 citation statements)

References 11 publications

(22 reference statements)

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“…All published literature on risk factors for recurrences is based on ocular SCs. Haber et al 14 found a recurrence rate of 16.6% for extraocular SC without analysing risk factors for recurrence. In the ocular region, a higher tumour stage, intraepithelial neoplasia, and an initial (benign) misdiagnosis are described as risk factors for recurrences.…”

Section: Discussionmentioning

confidence: 99%

Outcome after treatment for sebaceous carcinoma: A multicenter study

Veld

Keizer

Post

et al. 2022

Journal of Surgical Oncology

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Background: Sebaceous carcinoma (SC) is a rare malignant tumour whereby, comprehensive long-term data are scarce. This study aimed to assess the outcome of patients treated with resection for SC.Methods: Patients treated at four tertiary centres were included. Cumulative incidence curves were calculated for recurrences.Results: A total of 100 patients (57 males, 57%) were included with 103 SCs. The median age was 72 (range, 15-95) years with a median follow-up of 52 (interquartile range [IQR], 24-93) months. Most SCs were located (peri)ocular (49.5%). Of all SCs, 17 locally recurred (16.5%) with a median time to recurrence of 19 (IQR, months. The cumulative incidence probability for recurrence was statistically higher for (peri)ocular tumours (p = 0.005), and for positive resection margins (p = 0.001).Two patients presented with lymph node metastases and additional seven patients (8.7%) developed lymph node metastases during follow-up with a median time to metastases of 8 (IQR, 0.5-28) months. Three patients had concurrent in-transit metastases and one patient also developed liver and bone metastases during follow-up. Conclusion:SC is a rare, yet locally aggressive tumour. Positive resection margins and (peri)ocular SCs are more frequently associated with local recurrence. SC infrequently presents with locoregional or distant metastases.

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Section: Discussionmentioning

confidence: 99%

Outcome after treatment for sebaceous carcinoma: A multicenter study

Veld

Keizer

Post

et al. 2022

Journal of Surgical Oncology

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“…Periocular sebaceous carcinoma accounts for 1.5‐5% of eyelid malignancies in Western countries and 30% in India and East Asia . The tumours present as nodules which may ulcerate.…”

Section: Sebaceous Carcinomamentioning

confidence: 99%

“…Sebaceous carcinoma shows risk for significant morbidity and mortality independent of the anatomical site. Recurrence rates range from 4% to 28%, and the 5‐year survival rates range from 70% to 97% with a 10‐year survival of approximately 79% . Metastatic spread to regional lymph nodes or distant sites involving liver, lung, brain, and bones is seen in 14–25% of patients .…”

Section: Sebaceous Carcinomamentioning

confidence: 99%

Update on the pathology, genetics and somatic landscape of sebaceous tumours

et al. 2020

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Cutaneous sebaceous neoplasms show a predilection for the head and neck area of adults and include tumours with benign behaviour, sebaceous adenoma and sebaceoma, and sebaceous carcinoma with potential for an aggressive disease course at the malignant end of the spectrum. The majority of tumours are solitary and sporadic, but a subset of tumours may be associated with Lynch syndrome, also known as hereditary non‐polyposis colon cancer (HNPCC) and previously referred to as Muir‐Torre syndrome (now known to be part of Lynch syndrome). This review provides an overview of the clinical and histological features of cutaneous sebaceous neoplasia with an emphasis on differentiating features and differential diagnosis. It also offers insights into the recently described molecular pathways involved in the development of sebaceous tumours and their association with Lynch syndrome.

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Surgical Approach to Cutaneous Malignancy with Systemic Implications

Richey

Ferguson

2021

Dermato-Oncology Study Guide

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Sebaceous Carcinomas of the Skin: 24 Cases and a Literature Review

Cited by 9 publications

References 11 publications

Outcome after treatment for sebaceous carcinoma: A multicenter study

Outcome after treatment for sebaceous carcinoma: A multicenter study

Update on the pathology, genetics and somatic landscape of sebaceous tumours

Surgical Approach to Cutaneous Malignancy with Systemic Implications

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