An analytical reconstruction model of the spread-out Bragg peak using laser-accelerated proton beams

Tao, Li; Zhu, J.Q.; Xu, Xiaoying; Cao, Lin; Ma, Wu; Lu, Haiyang; Zhao, Yanying; Lu, Yuanrong; Chen, Jiaer; Yan, Xueqing

doi:10.1088/1361-6560/aa6fce

Cited by 7 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the photon therapy always causes the most severe damage on the tissue at the beginning of the path. Similar to the other radiotherapies, PBT not only induces the single-strand break (SSB) and double-strand break (DSB) of DNA directly but also induces an excessive production of reactive oxygen species (ROS), which has a longer lifetime to induce the damage of DNA subsequently. − Since the depth of BP is very thin, a proton beam normally needs to pass through certain scattering devices to produce a spread-out Bragg peak (SOBP) zone, which covers a larger area with a uniform dose for the practical applications. − …”

Section: Introductionmentioning

confidence: 99%

Gold-Nanoparticles-Enhanced Production of Reactive Oxygen Species in Cells at Spread-Out Bragg Peak under Proton Beam Radiation

Tsai

Niu

et al. 2023

ACS Omega

View full text Add to dashboard Cite

This study investigates the radiobiological effects of gold nanoparticles (GNPs) as radiosensitizers for proton beam therapy (PBT). Specifically, we explore the enhanced production of reactive oxygen species (ROS) in GNP-loaded tumor cells irradiated by a 230 MeV proton beam in a spread-out Bragg peak (SOBP) zone obtained by a passive scattering system. Our findings indicate that the radiosensitization enhancement factor is 1.24 at 30% cell survival fraction, 8 days after 6 Gy proton beam irradiation. Since protons deposit the majority of their energy at the SOBP region and interact with GNPs to induce more ejected electrons from the high-Z GNPs, these ejected electrons then react with water molecules to produce excessive ROS that can damage cellular organelles. Laser scanning confocal microscopy reveals the excessive ROS induced inside the GNP-loaded cells immediately after proton irradiation. Furthermore, the damage to cytoskeletons and mitochondrial dysfunction in GNP-loaded cells caused by the induced ROS becomes significantly severe, 48 h after proton irradiation. Our biological evidence suggests that the cytotoxicity of GNP-enhanced ROS production has the potential to increase the tumoricidal efficacy of PBT.

show abstract

Section: Introductionmentioning

confidence: 99%

Gold-Nanoparticles-Enhanced Production of Reactive Oxygen Species in Cells at Spread-Out Bragg Peak under Proton Beam Radiation

Tsai

Niu

et al. 2023

ACS Omega

View full text Add to dashboard Cite

show abstract

“…Thus the LIB has a larger energy spread, shorter pulse length (∼ps) [6] and multiple charge states compared with the traditional electrostatic accelerator. These different characteristics can bring new applications of LIB, for example, the electromagnetic field diagnostic with ps time resolution [7], generation of warm dense matter [8] and radiation dose deposition based on a wide energy spectrum [9].…”

Section: Introductionmentioning

confidence: 99%

Calibration and test of CsI scintillator ion detection system for tokamak magnetic field diagnosis based on laser-driven ion-beam trace probe (LITP)

Wu¹,

Yang²,

Xu³

et al. 2022

Nucl. Fusion

View full text Add to dashboard Cite

As a new diagnostic method of core electromagnetic field, laser driven ion-beam trace probe (LITP) is expected to realize the first application of the advanced laser accelerator in magnetic confinement fusion. The detector of LITP directly measures the distribution of the dispersed pulsed ions after they passed through the core plasma [1]. In such an environment of high temperature and radiation, the response and lifetime of the ion detector is very crucial. In this work, we have verified the feasibility of the LITP ion detection through systemic experiments. A CsI(Tl) scintillator coupled with an imaging system composed of optical lens and optical fiber array was calibrated on both the 4.5 MV Electrostatic Accelerator and the Compact LAser Plasma Accelerator (CLAPA) at Peking University. We found that the detectable proton density limit is achievable by using a tens of TW level laser system. The CsI(Tl) scintillator system was also tested on the HL-2A tokamak device to measure the real background noise caused by the hot plasma electrons and radiations. It survived in the harsh environment and the background noise was completely suppressed when using an ultrafast camera and microsecond shutter. These calibrations and tests verified the feasibility of the LITP detector.

show abstract

Semianalytical tool for spread-out Bragg peak optimization in an active energy-modulation proton therapy linac

Ronsivalle¹,

Nichelatti²,

Picardi³

et al. 2021

Nuclear Instruments and Methods in Physics Research Section A:

View full text Add to dashboard Cite

An analytical reconstruction model of the spread-out Bragg peak using laser-accelerated proton beams

Cited by 7 publications

References 17 publications

Gold-Nanoparticles-Enhanced Production of Reactive Oxygen Species in Cells at Spread-Out Bragg Peak under Proton Beam Radiation

Gold-Nanoparticles-Enhanced Production of Reactive Oxygen Species in Cells at Spread-Out Bragg Peak under Proton Beam Radiation

Calibration and test of CsI scintillator ion detection system for tokamak magnetic field diagnosis based on laser-driven ion-beam trace probe (LITP)

Semianalytical tool for spread-out Bragg peak optimization in an active energy-modulation proton therapy linac

Contact Info

Product

Resources

About