Development of novel amisulpride-loaded solid self-nanoemulsifying tablets: preparation and pharmacokinetic evaluation in rabbits

Gamal, Wael; Fahmy, Rania Samir; Mohamed, M. I.

doi:10.1080/03639045.2017.1322608

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…The relative bioavailability of SNE-L tablets compared to conventional tablets was on average approximately 200%. The improved oral bioavailability of VK1 from SNE-L tablets could be attributed to the enhanced dissolution rate in the gastrointestinal tract [ 30 , 38 , 39 ]. The nanoemulsions formed after self-dispersing in the gastrointestinal tract may enhance drug dissolution through numerous mechanisms, such as increased surface area, improved diffusion, and greater permeability, which ultimately improve the oral bioavailability of SNE-L tablets [ 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic Development of Self-Nanoemulsifying Liquisolid Tablets to Improve the Dissolution and Oral Bioavailability of an Oily Drug, Vitamin K1

Yong-tao¹,

Wang²,

Yang³

et al. 2018

Pharmaceutics

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The purpose of this study is to improve the dissolution and oral bioavailability of an oily drug, vitamin K1 (VK1) by combination of self-nanoemulsifying and liquisolid technologies. The optimal liquid self-nanoemulsifying drug delivery systems (SNEDDS) formulation including VK1 (oil), mixture of soybean lecithin and glycocholic acid (surfactant) and Transcutol HP (cosurfactant) was obtained according to ternary phase diagrams and a central composite design. Based on compatibility, adsorption capacity and dissolution profile, liquid SNEDDS was then solidified on Fujicalin® to form solid SNEDDS by liquisolid technology and compressed directly with excipients into self-nanoemulsifying liquisolid (SNE-L) tablets. Uniform nano-emulsion suspension was formed rapidly when the SNE-L tablets disintegrated in dissolution media and higher drug dissolution was observed compared with the conventional tablets. The results of pharmacokinetic study in beagle dogs showed that the mean Cmax and the area under the curve of SNE-L tablets were remarkably higher than those of conventional tablets, which were consistent with the results of the in vitro dissolution. The relative bioavailability of SNE-L tablets and conventional tablets was approximately 200%. In conclusion, this combination method showed promise to improve the dissolution and oral bioavailability of oily drug vitamin K1.

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Section: Resultsmentioning

confidence: 99%

Systematic Development of Self-Nanoemulsifying Liquisolid Tablets to Improve the Dissolution and Oral Bioavailability of an Oily Drug, Vitamin K1

Yong-tao¹,

Wang²,

Yang³

et al. 2018

Pharmaceutics

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“…Self-emulsifying systems are effective peptide and protein transporters because they delay digestion and increase permeability through GIT membranes, according to recent studies [19][20][21]. A number of methods, including adsorption, spray drying, spheronization, eutectic mixing, capsule filling, extrusion, and melt granulation, have been developed in recent years to transform liquid or semisolid components into dried form (powder) [22,23]. Solidified self-nanoemulsifying systems (S-SNEDDSs) provide several advantages over SNEDDS, including increased patient compliance and improved product stability for manufacturers.…”

Section: Overview Of Self-nanoemulsifying Drug-delivery Systemsmentioning

confidence: 99%

Self-Nanoemulsifying Drug Delivery System: Liquid, Supersaturable, and Solid Dosage Forms

Abbas

2022

Al-Rafidain J Med Sci

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A third of recently created drugs have poor water solubility and absorption. Innovative methods, such as self-nanoemulsifying drug delivery systems (SNEDDS), are being developed to address issues with pharmaceutical delivery and bioavailability. These systems, which are referred to as isotropic mixtures, are made up of the drug, a suitable oil, a surfactant, and either a co-surfactant or co-solvent. These elements combine to create a "oil in water (O/W)" nanoemulsion after being lightly stirred. Colloidal systems, including microemulsions and nanoemulsions, are being used more commonly in food, cosmetics, and pharmaceutical preparations to encapsulate, protect, and transport lipophilic components. The nanoscale particles used in these kinds of delivery systems have a number of potential benefits, including enhanced long-term stability, enhanced solubility, enhanced optical transparency, and enhanced bioavailability. To create SNEDDS, one can utilize a phase diagram technique or a statistical design of trials. For SNEDDS, switching from a liquid to a solid dose form may have improved stability as well as increased patient compliance. The design and production of SNEDDS and their effects on the bioavailability of several medications are the subject of numerous studies that are included in this review.

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“…SEM is employed to elucidate the structural and morphological features of s-SEDDS and the raw materials as well as to confirm the physical state of loaded drug [96].…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Self-Emulsifying Drug Delivery Systems: Easy to Prepare Multifunctional Vectors for Efficient Oral Delivery

AboulFotouh¹,

Allam²,

El-Badry³

2020

Current and Future Aspects of Nanomedicine

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Self-emulsifying drug delivery systems (SEDDS) have been mainly investigated to enhance the oral bioavailability of drugs belonging to class II of the Biopharmaceutics Classification System. However, in the past few years, they have shown promising outcomes in the oral delivery of various types of therapeutic agents. In this chapter, we discuss the recent progress in the application of SEDDS for oral delivery of protein therapeutics and genetic materials. The role of SEDDS in enhancing the oral bioavailability of P-glycoprotein and cytochrome P450 3A4 substrate drugs is also highlighted. Also, we discuss the most critical evaluation criteria of SEDDS. Additionally, we summarize various solidification techniques employed to transform liquid SEDDS to the more stable solid self-emulsifying drug delivery systems (s-SEDDS) that are associated with high patient compliance. This chapter provides a comprehensive approach to develop high utility SEDDS and their further transformation into s-SEDDS.

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Development of novel amisulpride-loaded solid self-nanoemulsifying tablets: preparation and pharmacokinetic evaluation in rabbits

Abstract: S-SNEDDS can be a very useful approach for providing patient acceptable dosage forms with improved oral dissolution and biovailability.

Cited by 10 publications

References 21 publications

Systematic Development of Self-Nanoemulsifying Liquisolid Tablets to Improve the Dissolution and Oral Bioavailability of an Oily Drug, Vitamin K1

Systematic Development of Self-Nanoemulsifying Liquisolid Tablets to Improve the Dissolution and Oral Bioavailability of an Oily Drug, Vitamin K1

Self-Nanoemulsifying Drug Delivery System: Liquid, Supersaturable, and Solid Dosage Forms

Self-Emulsifying Drug Delivery Systems: Easy to Prepare Multifunctional Vectors for Efficient Oral Delivery

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