A Cutoff for Age at Menarche Predicting Metabolic Syndrome in Egyptian Overweight/Obese Premenopausal Women

Abstract

Previous studies showed that early age at menarche is associated with increased risk of metabolic syndrome. However, the definition of early menarche at these studies was based on background data in the communities at which these studies was carried on. The aim of this work is to determine a cutoff for age at menarche discriminating presence or absence of metabolic syndrome in overweight/obese premenopausal women. This study included 204 overweight/obese women. Metabolic syndrome was defined according to NCEP-ATP III (National Cholesterol Education Program Adult Treatment Panel III) criteria. Of a total 204 participants, 82 (40.2%) had metabolic syndrome. By using receiver operating characteristic analysis, age at menarche ≤12.25 year discriminated individuals with from those without metabolic syndrome. The area under the curve was 0.76 (95% confidence interval, 0.70 to 0.83). Sensitivity, specificity, negative predictive value, and positive predictive value were 82%, 70%, 85%, and 64%, respectively. Age at menarche ≤12.25 years predicts the presence of metabolic syndrome in overweight/obese women.

Clinical and Anthropometric Characteristics of the Metabolically Unhealthy Phenotype in Adolescents with Adequate and High BMI

“…In this present study, a high frequency of EM was identified among MUH adolescents with adequate and high BMI, and among those who were between 10 and 14 years old. These findings are relevant, since several authors have pointed to a trend of reduction in the age at menarche in recent decades, which can be justified by important changes in body composition that occur during puberty [35,36,8]. In our data, among MUH adolescents, the significant correlation found between the age at menarche and body variables, such as BMI and BF%, corroborate this hypothesis.…”

Association of Early Menarche with Adolescent Health in the Setting of Rapidly Decreasing Age at Menarche

“…9 For metabolic syndrome, reaching menarche at age #12.25 years showed a higher sensitivity and negative predictive value in overweight/obese girls. 47 An AAM #11 years was associated with a higher risk for premature menopause. 11 In a Norwegian study, AAM !13 years was associated with a shorter duration of reproductive years.…”

Relationship between age at menarche and chromosome numerical abnormalities in chorionic villus among missed abortions: A cross‐sectional study of 459 women in China

“…The early menarche may be linked with increased harmful substances in the environment, especially related to exogenous hormone‐like substances through food additives and synthetic chemicals 15,16 . Early menarche might also be related to a variety of diseases including cardiovascular diseases, gynecological tumors, type 2 diabetes and gestational diabetes 17–20 . Studies also showed that age of menarche is associated with female fertility, 4,21,22 but no study has reported the relationship between the age of menarche and MA.…”

“…15,16 Early menarche might also be related to a variety of diseases including cardiovascular diseases, gynecological tumors, type 2 diabetes and gestational diabetes. [17][18][19][20] Studies also showed that age of menarche is associated with female fertility, 4,21,22 but no study has reported the relationship between the age of menarche and MA. Our study found that the age of menarche is not related to the occurrence of chromosome numerical abnormalities in patient group less than 30 years old, while in patients whose age are more than 30 years old and whose age of menarche are more than 12 years, the occurrence of chromosomes numeric abnormalities may be lower.…”