Digoxin Toxicity in a Neonate Caused by the Interaction with Carvedilol

Balmer, Christian; Cavigelli, Anna; Satir, Aylin; Good, Angela Caduff; Klauwer, Dietrich

doi:10.1055/s-0043-100220

Cited by 2 publications

(1 citation statement)

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“…Cases of digoxin intoxication with concomitant administration of carvedilol have been reported in neonates. 77,78 This interaction is likely mediated by carvedilol inhibition of p-glycoprotein, enhancing the absorption and reducing the renal secretion of digoxin, thus increasing serum digoxin concentrations.…”

Section: Drug-drug Interactions Involving Antiarrhythmic Agents In Ne...mentioning

confidence: 99%

Pharmacological Management of Cardiac Arrhythmias in the Fetal and Neonatal Periods: A Scientific Statement From the American Heart Association

Batra,

Silka,

Borquez

et al. 2024

Circulation

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Disorders of the cardiac rhythm may occur in both the fetus and neonate. Because of the immature myocardium, the hemodynamic consequences of either bradyarrhythmias or tachyarrhythmias may be far more significant than in mature physiological states. Treatment options are limited in the fetus and neonate because of limited vascular access, patient size, and the significant risk/benefit ratio of any intervention. In addition, exposure of the fetus or neonate to either persistent arrhythmias or antiarrhythmic medications may have yet-to-be-determined long-term developmental consequences. This scientific statement discusses the mechanism of arrhythmias, pharmacological treatment options, and distinct aspects of pharmacokinetics for the fetus and neonate. From the available current data, subjects of apparent consistency/consensus are presented, as well as future directions for research in terms of aspects of care for which evidence has not been established.

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Section: Drug-drug Interactions Involving Antiarrhythmic Agents In Ne...mentioning

confidence: 99%