Vaginal Delivery of Benzydamine Hydrochloride through Liposomes Dispersed in Mucoadhesive Gels

Abstract

Liposomal vaginal drug delivery systems are important strategy in the treatment of both topical and systemic diseases. The aim of this study was to develop a vaginal delivery system for benzydamine hydrochloride (BNZ) loaded liposomes dispersed into mucoadhesive gels. The delivery system was also designed for a once a day dosage and to obtain controlled release of the BNZ. For this purpose BNZ containing gel formulations using hydroxypropyl methylcellulose (

Mucoadhesive Vaginal Discs based on Cyclodextrin and Surfactants for the Controlled Release of Antiretroviral Drugs to Prevent the Sexual Transmission of HIV

“…As can be seen in Figure 2, the gel prepared as a reference (H batch) yields a viscosity value close to 4000 mPa•s, which is consistent with the manufacturer's data since we used Methocel K4M (the viscosity value of a 2% gel at 25 • C should be 4000 mPa•s) [30]. This value is similar to that obtained by other authors when measuring HPMC gels [31]. The high viscosity of this gel suggests it is a good potential candidate to ensure the sustained release of drugs from the freeze-dried gel, as it is able to hydrate quickly and subsequently block any additional uptake of liquids (such as vaginal fluid, which will be required to dissolve the drug so it can be released once the formulation is applied) [32].…”

Composite Thermoresponsive Hydrogel with Auranofin‐Loaded Nanoparticles for Topical Treatment of Vaginal Trichomonad Infection

“…The vaginal tissue poses unique challenges for topical formulations, since abundant moisture, mucins, and motility promote ready clearance of luminally applied formulations . Gels made from carbomer, cellulose, hyaluronic acid, or alginate have been developed as drug carriers, but the hydrophilic nature of these polymers limits drug loading yields for many hydrophobic pharmaceutical compounds such as AF, which has a logP value of 1.6 and aqueous solubility of only 0.015% w/w . In contrast, drug loading into PLGA‐based NPs allowed for a 13‐fold higher loading yield of 0.2% w/w in the final AF‐NP gel, thus permitting a much higher local drug dose in a smaller volume.…”

“…Several advanced formulations have been proposed for topical treatment in the urogenital tract and at other mucosal sites. [18][19][20][21] Among those, hybrid systems that combine multiple constituents and functionalities are particularly attractive, because they can combine advantages intrinsic to each constituent for synergy. For example, combinations of nanoparticles (NPs) and hydrogels can achieve such synergistic functionalities.…”

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

“…The developed lipogel was more effective than liposomes as it exhibited approximately 5-fold stronger mucoadhesive strength. Hence, HPMC K100M was shown to be a good choice of vehicle to form a lipogel attributed to its mucoadhesive property that eventually prolonged the retention time of the formulation in the vagina [80]. Moreover, Kenechukwu et al developed a mucoadhesive microgel encapsulating the miconazole nitrate (MN)-loaded solid lipid microparticles for local treatment of VVC and polycarbophil was employed as the mucoadhesive polymer [81].…”