The relationship between cognitive insight and cognitive performance among individuals with at-risk mental state for developing psychosis

Ohmuro, Noriyuki; Katsura, Masahiro; Obara, Chika; Kikuchi, Tatsuo; Hamaie, Yumiko; Sakuma, Atsushi; Iizuka, Kunio; Ito, Fumiaki; Matsuoka, Hiroo; Matsumoto, Kazunori

doi:10.1016/j.schres.2017.04.031

Cited by 21 publications

(22 citation statements)

References 40 publications

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“…In individuals at high risk for psychosis, deficits in the ability to learn new associations based on previously irrelevant cues are strongly correlated with impairments in insight , the capacity to appraise and modify distorted beliefs about anomalous experiences 47 . Impaired insight plays a central role in the development and maintenance of psychosis 48 .…”

Section: Discussionmentioning

confidence: 99%

Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning

et al. 2020

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Organisms must learn novel strategies to adapt to changing environments. Activity in different neurons often exhibits synchronization that can dynamically enhance their communication and might create flexible brain states that facilitate changes in behavior. We studied the role of gamma-frequency (~40 Hz) synchrony between prefrontal parvalbumin interneurons, in mice learning multiple new cue-reward associations. Voltage indicators revealed cell type-specific increases of cross-hemispheric gamma synchrony between parvalbumin interneurons, when mice received feedback that previously learned associations were no longer valid. Disrupting this synchronization by delivering out-of-phase optogenetic stimulation caused mice to perseverate on outdated associations, an effect not reproduced by in-phase stimulation or out-of-phase stimulation at other frequencies. Gamma synchrony was specifically required when new associations utilized familiar cues that were previously irrelevant to behavioral outcomes, not when associations involved novel cues, or for reversing previously learned associations. Thus, gamma synchrony is indispensable for reappraising the behavioral salience of external cues.

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Section: Discussionmentioning

confidence: 99%

Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning

et al. 2020

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“…De Vos et al 123 reported that cognitive insight was related to performance on implicit process in a working priming 2-back task and the ability to change behavior following feedback on an executive function task. Ohmuro et al 136 found that higher self-certainty was related to poorer executive function in a group at risk for psychosis. Vohs et al 11 found no relationship between executive function and either dimension of cognitive insight in first-episode psychosis.…”

Section: World Psychiatry 17:1 -February 2018mentioning

confidence: 99%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this review, we examine the recent research on the relationship of insight with behavior, mood and perceived quality of life, on its complex roots, and on the effects of existing and emerging treatments. This research indicates that poor insight predicts poorer treatment adherence and therapeutic alliance, higher symptom severity and more impaired community function, while good insight predicts a higher frequency of depression and demoralization, especially when coupled with stigma and social disadvantage. This research also suggests that poor insight may arise in response to biological, experiential, neuropsychological, social-cognitive, metacognitive and socio-political factors. Studies of the effects of existing and developing treatments indicate that they may influence insight. In the context of earlier research and historical models, these findings support an integrative model of poor insight. This model suggests that insight requires the integration of information about changes in internal states, external circumstances, others' perspectives and life trajectory as well as the multifaceted consequences and causes of each of those changes. One implication is that treatments should, beyond providing education, seek to assist persons with schizophrenia to integrate the broad range of complex and potentially deeply painful experiences which are associated with mental illness into their own personally meaningful, coherent and adaptive picture.

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“…In individuals at high risk for psychosis, deficits in the ability to learn new associations based on previously irrelevant cues (measured by the WCST) are strongly correlated with impairments in insight, the capacity to appraise and modify distorted beliefs about anomalous experiences 51 . Impaired insight is believed to play a central role in the development and maintenance of psychosis 52 .…”

Section: Relevance To Diseasementioning

confidence: 99%

Interhemispheric gamma synchrony between parvalbumin interneurons supports behavioral adaptation

Cho

Davidson

Marshall

et al. 2019

Preprint

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Organisms must learn novel strategies to adapt to changing environments. Synchrony, which enhances neuronal communication, might create dynamic brain states, facilitating such adaptation. Although synchronization is common in neural systems, its functional significance remains controversial. We studied the role of gamma-frequency (~40 Hz) synchronization, promoted by parvalbumin interneurons, in mice learning multiple new cue-reward associations. Voltage imaging revealed cell type-specific increases of interhemispheric gamma synchrony within prefrontal parvalbumin interneurons, when mice received feedback that previously-learned associations were no longer valid. Disrupting this synchronization by delivering out-of-phase optogenetic stimulation caused mice to perseverate on outdated associations, an effect not reproduced by stimulating in-phase or out-of-phase at other frequencies. Gamma synchrony was specifically required when new associations utilized familiar cues that were previously irrelevant to behavioral outcomes, not when associations involved novel cues, or for reversing previously learned associations. Thus, gamma synchrony is indispensable for reappraising the behavioral salience of external cues.

show abstract

The relationship between cognitive insight and cognitive performance among individuals with at-risk mental state for developing psychosis

Cited by 21 publications

References 40 publications

Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning

Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Interhemispheric gamma synchrony between parvalbumin interneurons supports behavioral adaptation

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