Microstructural alterations owing to handling of bovine pericardium to manufacture bioprosthetic heart valves: A potential risk for cusp dehiscence

Mao, Jifu; Wang, Y.; Philippe, E; Cianciulli, Tomás Francisco; Veselý, Ivan; How, Daniel; Bourget, Jean-Michel; Germain, Lucie; Zhang, Z.; Guidoin, Robert

doi:10.1016/j.morpho.2017.03.003

Cited by 8 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For patients with hepatic failure, when performing thoracotomy, the bilateral pleura should not be opened. If pleural damage and breakage is observed, an autologous or allogeneic pericardial patch should be used to close the breakage (29), and this is essential to prevent postoperative wound dehiscence, exudation and infection (30,31). A sternal incision, intercostal incision or a robot can be used to perform coronary artery bypass graft.…”

Section: Discussionmentioning

confidence: 99%

Coronary artery bypass graft combined with liver transplantation in patients with advanced alcoholic liver cirrhosis: A case report

et al. 2020

View full text Add to dashboard Cite

Performing cardiothoracic surgery on patients with advanced liver failure and liver cirrhosis is high-risk for patients. Coronary artery bypass grafting is the most effective treatment for patients with liver failure that is complicated with severe coronary heart disease, and who cannot be treated using coronary stent intervention. In the current study, one case of coronary artery bypass grafting combined with liver transplantation was assessed, with the patient exhibiting advanced alcoholic liver cirrhosis. A coronary artery bypass graft was performed to relieve angina pectoris. Following surgery, wound exudation, secondary infection, liver failure, pleuroperitoneal fluid leakage, hypoproteinemia and other adverse treatment results occurred, and the chest wound did not heal. Allograft liver transplantation was subsequently performed and, following surgery, the chest wound healed gradually after debridement, and the patient recovered.

show abstract

Section: Discussionmentioning

confidence: 99%

Coronary artery bypass graft combined with liver transplantation in patients with advanced alcoholic liver cirrhosis: A case report

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Adverse events related to bovine pericardium heart valves have been well documented. The structure of the collagen bundles in the leaflets acts as a key factor in determining the in vivo fate of the valves . The preservation of the wavy structure and individualized collagen filaments is known to play an important part in determining the mechanical properties of the pericardium.…”

Section: Introductionmentioning

confidence: 99%

Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves

et al. 2019

View full text Add to dashboard Cite

Transcatheter aortic valve implantation (TAVI) has gained considerable acceptance in the past decade due to its lower risks than conventional open-heart surgery.However, the deformation and delamination of the leaflets during the crimping procedure have raised questions about the durability and long-term serviceability of the pericardium tissue from which the leaflets are made. The collagen architecture, wall thickness and mechanical properties of donkey pericardium were investigated to assess its suitability as an alternative material for the manufacture of heart valves.Coupons sampled from different locations of donkey pericardium were investigated.Bovine, equine, and porcine pericardium specimens served as controls. The donkey pericardium had a similar surface morphology to that of the control pericardia except for the wavy topology on both the fibrous and serous sides. The average thickness of donkey pericardium (ca. 120 µm) was significantly lower than that from bovine (375 µm) and equine (410 µm), but slightly higher than that from porcine (99 µm) specimens. The interlaced wavy collagen bundles in the pericardium were composed of collagen fibers about 100 nm in diameter. This unique structure ensures that the donkey pericardium has a comparable ultimate tensile strength (UTS) and a much higher failure strain than the commercial pericardia used for the manufacture of heart valves. The donkey pericardium has an organized wavy collagen bundle architecture similar to that of bovine pericardium and has a satisfactory UTS and high failure strain. The thin and strong donkey pericardium might be a good candidate valve leaflet material for TAVI. K E Y W O R D S collagen architecture, donkey pericardium, tissue thickness, transcatheter heart valve | 977 MAO et Al. How to cite this article: Mao J, Rassoli A, Tong Y, et al. Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves.

show abstract

“…Bioprostheses afford patients the opportunity to avoid rigorous anticoagulation in exchange for limited long-term durability secondary to wellrecognized modes of failure. [1][2][3] Valvular heart disease remains a global management challenge of access to optimal therapy, especially in children and in developing countries where rheumatic disease remains prevalent. 4 The ideal valve prosthesis provides for nonthrombogenic long-term durability and the potential to adapt to somatic growth.…”

mentioning

confidence: 99%

In vivo functional assessment of a novel degradable metal and elastomeric scaffold-based tissue engineered heart valve

Coyan

D’Amore

Matsumura

et al. 2019

The Journal of Thoracic and Cardiovascular Surgery

View full text Add to dashboard Cite

Objective: Ideal heart valve solutions aim to provide thrombosis-free durability. A scaffold-based polycarbonate urethane urea tissue-engineered heart valve designed to mimic native valve microstructure and function was used. This study examined the acute in vivo function of a stented tissue-engineered heart valve in a porcine model. Methods: Trileaflet valves were fabricated by electrospinning polycarbonate urethane urea using double component fiber deposition. The tissue-engineered heart valve was mounted on an AZ31 magnesium alloy biodegradable stent frame. Five 80-kg Yorkshire pigs underwent open tissue-engineered heart valve implantation on cardiopulmonary bypass in the pulmonary position. Tissue-engineered heart valve function was echocardiographically evaluated immediately postimplant and at planned study end points at 1, 4, 8, and 12 hours. Explanted valves underwent biaxial mechanical testing and scanning electron microscopy for ultrastructural analysis and thrombosis detection.Results: All 5 animals underwent successful valve implantation. All were weaned from cardiopulmonary bypass, closed, and recovered until harvest study end point except 1 animal that was found to have congenital tricuspid valve dysplasia and that was euthanized postimplant. All 5 cases revealed postcardiopulmonary bypass normal leaflet function, no regurgitation, and an average peak velocity of 2 m/s, unchanged at end point. All tissue-engineered heart valve leaflets retained microstructural architecture with no platelet activation or thrombosis by scanning electron microscopy. There was microscopic evidence of fibrin deposition on 2 of 5 stent frames, not on the tissueengineered heart valve. Biaxial stress examination revealed retained postimplant mechanics of tissue-engineered heart valve fibers without functional or ultrastructural degradation.Conclusions: A biodegradable elastomeric heart valve scaffold for in situ tissueengineered leaflet replacement is acutely functional and devoid of leaflet microthrombosis.

show abstract

Microstructural alterations owing to handling of bovine pericardium to manufacture bioprosthetic heart valves: A potential risk for cusp dehiscence

Cited by 8 publications

References 40 publications

Coronary artery bypass graft combined with liver transplantation in patients with advanced alcoholic liver cirrhosis: A case report

Coronary artery bypass graft combined with liver transplantation in patients with advanced alcoholic liver cirrhosis: A case report

Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves

In vivo functional assessment of a novel degradable metal and elastomeric scaffold-based tissue engineered heart valve

Contact Info

Product

Resources

About