Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults

Haskell-Ramsay, Crystal F.; Stuart, RC; Okello, Edward; Watson, Anthony

doi:10.1007/s00394-017-1454-7

Cited by 76 publications

(105 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, our results are consistent with previous animal and epidemiological studies that suggest anti-depressive effects of a flavonoid-rich diet (13,18,(41)(42)(43) . They also are in keeping with experimental data on the acute effects of WBB on positive mood in children and young adults (15,16) , and the acute effect of grape juice on mood in healthy adults (44) . Unlike a previous acute intervention study, we did not observe a significant effect of WBB on momentary mood (i.e.…”

Section: Discussionsupporting

confidence: 78%

Effect of 4 weeks daily wild blueberry supplementation on symptoms of depression in adolescents

et al. 2020

View full text Add to dashboard Cite

Adolescence is an important period for cognitive maturation and emotional regulation, and this age group is particularly vulnerable to developing depression. Diets rich in fruits and vegetables have been associated with decreased risk of developing depressive disorders across the lifespan, maybe due to the high flavonoid content of these foods. Previously, we have shown increases in transient positive affect (PA) in both children and young adults 2 h after administration of a wild blueberry (WBB) intervention. Here, using a randomised double-blind, placebo-controlled trial, we investigated the effects of 4 weeks, daily WBB supplementation (containing about 253 mg anthocyanins) on transient and chronic mood in adolescents. Healthy 12–17-year old (n 64, thirty-five females) participants were randomly assigned to receive either a WBB or matched placebo supplementation. Depression and anxiety symptoms were assessed before and after the intervention period using the Mood and Feeling Questionnaire and Revised Child Anxiety and Depression Scale. Transient affect was assessed before, 2 weeks and at 4 weeks using PA and negative affect. Following the intervention period, there were significantly fewer self-reported depression symptoms in participants who were supplemented with WBB compared with placebo (P = 0·02, 95 % CI –6·71, –5·35). There was no between-group effect on anxiety symptoms or on transient affect. Further investigation is required to identify specific mechanisms that link flavonoids consumption and mood. If replicated, the observed effects of WBB supplementation may be a potential prevention strategy for adolescent depression and may have benefits for public mental health.

show abstract

Section: Discussionsupporting

confidence: 78%

Effect of 4 weeks daily wild blueberry supplementation on symptoms of depression in adolescents

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A possible factor that could justify this response is the protocol duration that we used. Our data could be related to those reported by Haskell-Ramsay who recently showed that the acute grape juice consumption did not influence the memory performance in healthy young adults [43]. These findings led us to hypothesize that repeated/chronic consumption of --------------------------------------------------…”

Section: Sift Desksupporting

confidence: 91%

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

Elsner¹,

Trevizol²,

Bassôa³

et al. 2018

SDRP-JCMP

View full text Add to dashboard Cite

Background: Emerging evidences have been pointed out that exercise in combination with dietary factors is able to affect molecular events related to synaptic plasticity and cognitive improvement. Therefore, this study sought to verify the impact of grape juice consumption and/or exercise in plasma neurotrophic factor (BDNF) levels and memory performance in elderly women. Methods: Nineteen healthy elderly women were randomly distributed in two groups: Grape Juice Group (GJG, n=9) and Grape Juice + Exercise Group (GJEG, n=10). The GJG was instructed to drunk daily the grape juice (400 ml) for 30 days, while the GJEG was also submitted to a physical exercise intervention (twice a week, 60 min/session). Memory function was assessed via the MoCA (Montreal Cognitive Assessment) and blood sampling was taken for BDNF analysis pre/post intervention in both groups. Results: It was observed a significant increase on BDNF levels in GJG (p=0.000) and GJEG (p=0.041) after intervention, while the memory improvement was verified only in GJEG (p=0.024). No differences between groups were found in the variables. Conclusion: In conclusion, the grape juice consumption per se is capable to modulates/increases BDNF levels, response that was not potentiated by exercise practice. On the other hand, the memory performance was improved only when grape juice consumption is combined to exercise intervention in healthy elderly women.

show abstract

“…Based on an alpha of 0.05, 80% power and a Cohen's d effect size of 0.8, a G * power [26] calculation determined that a total sample size of 18 would be required 1 . In addition, considering the cross-over design of the study and that previous acute flavonoid intervention trials of similar design have shown positive effects on cognitive performance with a comparable number or fewer subjects [27,28], a sample size of 18 for this trial was considered appropriate. All participants completed both arms of the trial.…”

Section: Participantsmentioning

confidence: 99%

“…3, there was a trend towards the blueberry beverage attenuating the increase in systolic blood pressure evident following the control drink (mean change from baseline = 2. 28 . Also, despite a decline in mean plasma concentration of BDNF following the control beverage which appeared to be attenuated following the blueberry beverage (mean change from baseline = -46.54 vs -9.70 respectively), this difference was not significant (t(8) = -1.79, p > 0.05; BCa 95% CI [-89.64, 5.26] 4 ).…”

Section: Vascular Function and Plasma Concentration Of Bdnfmentioning

confidence: 99%

“…Furthermore, evidence of acute effects of berry-derived flavonoids on cognition comes from recent research by Watson et al suggesting that acute supplementation with blackcurrant can lead to benefits in terms of brain function which may be due to inhibition of monoamine oxidase-B [8]. In addition, an acute study with healthy younger adults found evidence of improved cognitive function and mood following consumption of purple grape juice, including reduced reaction time on a composite measure of attention and increased self-reported calmness [9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute effects of flavonoid-rich blueberry on cognitive and vascular function in healthy older adults

Dodd

Williams

Butler

et al. 2019

NHA

View full text Add to dashboard Cite

BACKGROUND: Consumption of flavonoids, natural compounds found in foods such as berries and cocoa, have been shown to be beneficial for cognitive function. However, less is known about potential mechanisms and acute benefits for the older population. OBJECTIVE: To determine whether acute intake of flavonoid-rich blueberry could have beneficial effects on cognitive function in a sample of healthy older adults and identify possible mechanisms. METHODS: A cross-over randomised controlled trial (RCT) was conducted (N = 18) with volunteers receiving a flavonoidrich blueberry beverage (579mg of antho-and pro-cyanidins) on one visit and a sugar-matched control on another. Cognitive function was measured at baseline, 2 and 5 hours post consumption of the intervention and blood pressure (BP), arterial stiffness and plasma brain-derived neurotrophic factor (BDNF) concentration at baseline and an hour post-intervention. RESULTS: Whilst there was no significant effect of the intervention on global cognitive function, performance was significantly different at 2 compared to 5 hours following the control beverage (p < 0.05), with a decline in performance relative to baseline at 2 hours, whereas cognitive function improved following the blueberry beverage at both post intervention time points. There was also a trend towards the blueberry beverage attenuating the increase in systolic BP evident following the control drink (p = 0.08). Finally, there was a decrease in plasma concentration of BDNF post consumption of the control drink which was attenuated following the blueberry beverage, although not significantly (p > 0.05). CONCLUSIONS: A single dose of flavonoid-rich blueberry could have a potentially protective effect on cognitive function in healthy older adults, possibly due to improved cerebrovascular function and positive interactions with cell signalling pathways involved in cognitive processes.

show abstract

Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults

Cited by 76 publications

References 67 publications

Effect of 4 weeks daily wild blueberry supplementation on symptoms of depression in adolescents

Effect of 4 weeks daily wild blueberry supplementation on symptoms of depression in adolescents

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

Acute effects of flavonoid-rich blueberry on cognitive and vascular function in healthy older adults

Contact Info

Product

Resources

About