Correlation between serum uric acid levels and residual platelet reactivity in patients undergoing PCI

The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor

“…Uric acid, as an acidic substance, is prone to precipitate urate crystals mainly consisting of monosodium urate (MSU) during acid-base imbalance in the body [ 86 ]. These crystals can directly deposit on the vascular wall damaging the endothelium, causing platelet aggregation and contributing to coronary atheroma plaque formation [ 86 ].…”

“…Uric acid, as an acidic substance, is prone to precipitate urate crystals mainly consisting of monosodium urate (MSU) during acid-base imbalance in the body [ 86 ]. These crystals can directly deposit on the vascular wall damaging the endothelium, causing platelet aggregation and contributing to coronary atheroma plaque formation [ 86 ]. Similarly, MSU crystals stimulate macrophage activation, leading to the activation of NLRP-3 inflammatory vesicles and ultimately the production and release of IL-1β and IL-18, which can mediate inflammation, apoptosis and necrosis and cause an inflammatory cascade response [ 87 ].…”

Uric acid levels are associated with severity and mortality in patients with acute coronary syndrome

“…Related studies have shown that hyperuricemia not only is an independent risk factor for coronary heart disease, but also has important predictive value for the severity and prognosis of coronary heart disease. Patients with hyperuricemia have an increased risk of side effects of antiplatelet drugs and thrombosis and ischemia after PCI (31). The detection of UA is of great significance to the precautions for the PCI treatment of patients with clinical coronary heart disease.…”