Fetal programming of the metabolic syndrome

Marciniak, Aleksandra; Patro-Małysza, Jolanta; Kimber-Trojnar, Żaneta; Marciniak, Beata; Oleszczuk, Jan; Leszczyńska‐Gorzelak, Bożena

doi:10.1016/j.tjog.2017.01.001

Cited by 127 publications

(99 citation statements)

References 46 publications

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“…Pregnancy is a critical period when the system and organs of a new human body develops. Any disruption to the environment in which the fetus grows may result in developmental adaptations that produce permanent alterations to structural and physiological metabolic functions of the fetus [58,59]. A hypothesis proposed in 1990 by the British epidemiologist David Barker, known as the Barker hypothesis, states that the environment during embryonic and fetal development increases the susceptibility of developing certain postnatal diseases later in life [60].…”

Section: Discussionmentioning

confidence: 99%

Circadian rhythm and its association with birth and infant outcomes: research protocol of a prospective cohort study

Kaur

Teoh

Shukri

et al. 2020

BMC Pregnancy Childbirth

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Background: Circadian rhythm plays an important role as our internal body's clock that synchronizes behavior and physiology according to the external 24-h light-dark cycle. Past studies have associated disrupted circadian rhythm with higher risk of miscarriages, preterm birth and low birth weights. This paper described the protocol of a prospective cohort study which aims to determine the circadian rhythm in pregnant women, identify its association with maternal factors during pregnancy, gestational weight gain, birth and infant outcomes. Methods: Ten government maternal and child health clinics in Kuala Lumpur, Malaysia will be randomly selected. Sample size of 438 first-trimester pregnant women will be followed-up until the birth of their infant. Salivary melatonin and cortisol concentration among subsample will be determined using enzyme-linked immunosorbent assay. Data on sleep quality, psychological distress and morningness/eveningness chronotype of pregnant women will be collected using validated questionnaires. Pedometer will be used to measure 5-day physical activity data. Total gestational weight gain will be determined at the end of pregnancy. Utilization of 3-day food record is to capture meal timing and nutrient intake. All measurements will be done in 2nd and 3rd trimester. Birth outcomes will be collected through clinic records and Centers for Disease Control and Prevention (CDC) Neonatal questionnaire. Infants will be followed-up at 6 and 12 months old to obtain anthropometric measurements. Discussion: There is a growing recognition of the role of maternal circadian rhythm, which entrains fetal circadian rhythms that may subsequently have long-term health consequences. The present study will identify the effect of circadian rhythm on pregnancy outcomes and infant growth in the first year of life.

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Section: Discussionmentioning

confidence: 99%

Circadian rhythm and its association with birth and infant outcomes: research protocol of a prospective cohort study

Kaur

Teoh

Shukri

et al. 2020

BMC Pregnancy Childbirth

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“…The correlations between birth weight and insulin resistance could be explained by the theory of "metabolic programming" during fetal development, according to which various factors that affect the fetus, may cause life-lasting changes and influence further development of metabolic disorders 30 .…”

Section: Discussionmentioning

confidence: 99%

The role of multiple regression analysis in prediction of insulin resistance in overweight and obese children

Pavlyshyn¹

2019

Arch Balk Med Union

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Le rôle de l'analyse de régression multiple dans la prédiction de la résistance à l'insuline chez les enfants avec surpoids et obèses Introduction. L'excédent de poids et l'obésité constituent une épidémie à l'échelle mondiale chez les enfants de tous les groupes d'âge. Les enfants obèses présentent un risque accru de résistance à l'insuline, de maladies cardiovasculaires (y compris l'hypertension), de fractures osseuses et de problèmes psychologiques. À cet égard, la résistance à l'insuline est devenue l'un des problèmes de santé les plus graves chez les enfants avec surpoids et obèses. L'objectif de l'étude était d'étudier les traits spécifiques du métabolisme des glucides chez les enfants avec surpoids et obèses, d'identifier les facteurs clés de la résistance à l'insuline et de développer un modèle pronostique basé sur une analyse de régression pour prédire son occurrence. Matériels et méthodes. Des mesures anthropométriques, la collecte de données sur l'histoire et des examens de laboratoire ont été effectués chez 90 enfants obèses et 20 enfants avec surpoids de 10 à 17 ans. L'analyse de régression multiple a été utilisée pour ABSTRACT Introduction. Overweight and obesity is a global epidemic among children of all age groups. Obese children are at increased risk of insulin resistance, cardiovascular disease (including arterial hypertension), as well as bone fractures and psychological problems. In this regard, insulin resistance has become one of the most serious health concerns in overweight and obese children. The objective of the study was to investigate the specifics for carbohydrate metabolism in overweight and obese children, to identify the key factors for insulin resistance and to develop a regression analysis-based prognostic model to predict its occurrence. Material and methods. In 90 obese and 20 overweight children aged between 10-17 years, anthropometric measurements, history data collection and laboratory investigations were performed. Multiple regression analysis has been used to develop a mathematical model for prediction of insulin resistance. Results. Such variables as weight, body mass index, waist and hip circumferences, abdominal type obesity, family history, duration of breastfeeding (if any), birth weight, sedentary lifestyle, leptin and adiponectin levels and dyslipidemia were closely related to fasting glucose levels and insulin/insulin resistance indices.

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“…Специалисты, и не только акушеры-гинекологи, знают, что повышение массы тела сопряжено с самыми разными заболеваниями, а значит ликвидация этого фактора в прямом смысле слова «оздоровит» пациентку. У ги-некологов свои счеты с ожирением и свои интересы в борьбе с ним -сохранение репродуктивного потенциала, восстановление и поддержание фертильности, прегравидарная подготовка, удержание правильного менструального цикла [16][17][18]. Современный взгляд практикующих врачей на патогенез избыточной массы тела и ожирения предполагает значимую роль психосоматического компонента, когда сложный и многокомпонентный букет генетических и эндокринно-обменных факторов серьезно усугубляет факторы психологические.…”

Section: Discussionunclassified

Women's reproductive health and features of eating behavior

Елгина

Захаров

Рудаева

2019

Fundamentalʹnaâ i kliničeskaâ medicina

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Aim. To study reproductive health of women with and without eating disorders.Materials and Methods. We designed an original questionnaire, surveyed and analyzed the medical records of 200 women of reproductive age.Results. All the study participants suffered from eating disorders. Out of 200 patients, 46 (23%), 120 (63%), and 34 (17%) had emotional, restrictive, and external eating disorders, respectively. Women with normal body mass index (BMI) or overweight were more likely to have an avoidant/restrictive food intake disorder while emotional and external types prevailed among obese patients. Fibrocystic breast changes, uterine fibroids, polycystic ovary syndrome, infertility, and breast cancer were significantly more common in women with obesity (r = 0.74 for gynecological diseases in total). Pelvic inflammatory disease was more frequently diagnosed in women with emotional eating disorders while fibrocystic breast changes, uterine fibroids, and polycystic ovary syndrome were more prevalent in those with restrictive food intake disorder. Breast cancer prevailed in women with external eating disorders.Conclusion. Women of reproductive age are frequently diagnosed with different types of eating disorders. Obese women are more likely to have reproductive system disease. Each of eating disorders correlate with different gynecological diseases.

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Fetal programming of the metabolic syndrome

Cited by 127 publications

References 46 publications

Circadian rhythm and its association with birth and infant outcomes: research protocol of a prospective cohort study

Circadian rhythm and its association with birth and infant outcomes: research protocol of a prospective cohort study

The role of multiple regression analysis in prediction of insulin resistance in overweight and obese children

Women's reproductive health and features of eating behavior

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