Increased levels of soluble <scp>CD</scp>163 in periodontitis patients

Detzen, Laurent; Chen, Steven C. Y.; Cheng, Bin; Papapanou, Panos N.; Lalla, Evanthia

doi:10.1111/jcpe.12731

Cited by 10 publications

(16 citation statements)

References 41 publications

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“…In this study, when we correlated the protein and gene expression of CD163 with the demographic variables and periodontal parameters in both groups, we found that though in CP (Group I), CD163 levels did not show a positive correlation with demographic and periodontal parameters ( Table 2), however, in the CP+DM (Group II), it showed a significant positive correlation with PI (p-value 0.001), BOP (p-value 0.001), PPD (p-value 0.001), and CAL (p-value 0.001) ( Table 3). This was in accordance with the Detzen et al study, where they reported that CD163 expression in saliva and serum samples of periodontitis patients was highly correlated with periodontal parameters suggesting the relationship between CD163 levels and periodontal destruction [17]. Therefore, an increased level of CD163 in our study provides a better understanding of its role in the pathology of periodontal destruction in type II diabetes mellitus.…”

Section: Discussionsupporting

confidence: 93%

“…Recently, sCD163 has been identified as a biomarker for the diagnosis, prognosis, and monitoring of disease progression. Reports by Detzen et al have revealed the association of CD163 in saliva with periodontitis subjects [17]. Several studies have already proven that the subgingival biofilm is a primary reservoir of pathognomonic bacteria and cytotoxic agents in established periodontitis.…”

Section: Discussionmentioning

confidence: 99%

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Role of Cluster of Differentiation 163 in Diabetes-Periodontitis Interplay

Ruth

Mahendra

Kumar

et al. 2020

Cureus

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Background The aim of the present study was to assess and quantify cluster of differentiation 163 (CD163) protein levels and CD163 messenger RNA (mRNA) gene expression in subgingival plaque samples of generalized chronic periodontitis subjects with and without type II diabetes mellitus (DM). Materials and methods Eighty chronic periodontitis subjects were selected and divided into 40 systemically healthy, generalized chronic periodontitis subjects (Group I) and 40 generalized chronic periodontitis subjects diagnosed with type II diabetes mellitus (Group II). Age, body mass index (BMI), income, plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded. CD163 protein and gene expressions were quantified and compared between the groups. Results The mean age, BMI, income, PI, BOP %, and CD163 protein and gene expression were higher in Group II (p< 0.05) as compared to Group I. In Group I, CD163 protein levels showed a negative correlation with respect to BMI and PI, and this was statistically significant. In Group II, all the periodontal parameters showed a positive correlation with CD163 protein levels. Overall, PI and BOP % were significantly correlated with CD163 protein levels. Both CD163 protein and gene expression showed a negative correlation with each other (p= 0.001). Conclusion The elevated protein levels of CD163 in the subgingival plaque samples of generalized chronic periodontitis individuals with type II diabetes mellitus signify the involvement of CD163 in the pathogenesis of both periodontitis and diabetes mellitus. CD163 can play a challenging role as a diagnostic, as well as a prognostic biomarker, in both these inflammatory diseases.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Role of Cluster of Differentiation 163 in Diabetes-Periodontitis Interplay

Ruth

Mahendra

Kumar

et al. 2020

Cureus

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“…A study done by Detzen et al . [ 15 ] in saliva and serum of periodontitis patients demonstrated elevated serum levels of sCD163 (720.0 ± 330.6 ng/ml) which are comparable to the serum sCD163 levels of the present study. The subdue decrease in the GCF sCD163 levels from the serum sCD163 levels may be due to the molecular weight of sCD163 (130 kDa) which is higher when compared to the most commonly found proteins in GCF which are <79 kDa.…”

Section: Discussionsupporting

confidence: 87%

“…Oral hygiene status and inflammatory status were recorded using oral hygiene index simplified (OHIS)[ 18 ] and gingival index (GI)[ 19 ] at the time of clinical examination. BoP was recorded as a dichotomous index[ 15 ] (present or absent) and was expressed in percentage of bleeding. To maintain standardization and intra-examiner reproducibility probing depth (PD), CAL was recorded by a single examiner using a UNC-15 probe.…”

Section: Methodsmentioning

confidence: 99%

“…[ 12 13 ] Several studies have proven the increased presence of sCD163 in other body fluids during chronic inflammatory conditions such as rheumatoid arthritis, atherosclerosis, and metabolic syndrome-related conditions such as diabetes, obesity, and chronic kidney disease. [ 13 14 15 ] Although increased levels of sCD163 were found in serum and saliva of periodontitis patients,[ 15 ] the exact variation of the same in the gingival crevicular fluid (GCF) of periodontal health and disease is not clear till date. sCD163 is one such marker of macrophages that can be measured consistently even in smaller amounts with low intra-individual variability.…”

Section: Introductionmentioning

confidence: 99%

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Soluble CD163 as a biomarker of periodontal disease – A biochemical study using enzyme-linked immunosorbent assay

Sai¹,

Manjunath²,

Kumar³

et al. 2020

J Indian Soc Periodontol

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Background: The aim of the study was to evaluate the levels of soluble CD163 (sCD163) in gingival crevicular fluid (GCF) and blood serum of individuals having periodontitis, gingivitis, and healthy periodontium. Further, the role of sCD163 as a biomarker of periodontal disease was also assessed. Materials and Methods: A minimum of 5-μl GCF and 10 ml of venous blood was collected using a micropipette and 10-ml syringe, respectively, from the study population which was divided into three groups as healthy (Group I, n = 10), gingivitis (Group II, n = 10), and periodontitis (Group III, n = 10). sCD163 samples were assessed using a commercially available sCD163 enzyme-linked immunosorbent assay kit. Clinical parameters such as oral hygiene index simplified, gingival index (GI), percentage of sites with bleeding on probing, probing depth, and clinical attachment loss were recorded. Results: The mean serum sCD13 levels were 743.45 ± 51.17 ng/ml, 563.25 ± 103.74 ng/ml, and 431.0 ± 31.08 ng/ml when compared to the mean GCF sCD163 levels which were 59.81 ± 7.61 ng/ml, 38.93 ± 12.42 ng/ml, and 30.49 ± 12.60 ng/ml for periodontitis, gingivitis, and healthy individuals, respectively. The sCD163 levels were higher in patients with periodontitis when compared to the periodontally healthy individuals. Conclusion: Within the limitations of the present study, it can be concluded that sCD163 levels can be used as a diagnostic marker of disease as its levels are remarkably increased in GCFs of patients having periodontitis.

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Baseline interleukin‐10, CD163, and tumor necrosis factor‐like weak inducer of apoptosis (TWEAK) gingival tissue levels in relation to clinical periodontal treatment outcomes: A 12‐week follow‐up study

Yılmaz

Demir

Gürsoy

et al. 2022

Journal of Periodontology

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Background:The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival tissue levels of M2 macrophage activation-related proteins CD163, interleukin (IL)-10, interferon (IFN)-γ, and tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and the CD163/TWEAK ratio. Methods: Eighty-eight gingival tissue samples from 44 Stage III/IV, Grade C periodontitis patients (18 smokers) and 41 tissue samples from 41 periodontally healthy participants (18 smokers) were evaluated. Clinical parameters were recorded in periodontally healthy individuals at baseline and in periodontitis patients at pre-treatment and 2, 6, and 12 weeks following therapy. IL-10, IFN-γ, CD163, and TWEAK levels were analyzed with Luminex technique.Results: Tissue levels (median, 1 st -3 rd quartile) of IL-10 (pg/ng protein), CD163 (pg/μg protein) and TWEAK (pg/μg protein) were as follows: IL-10 periodontitis:

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Increased levels of soluble CD163 in periodontitis patients

Abstract: Our findings suggest that CD163 may be involved in the pathogenesis of periodontitis and its link with systemic conditions.

Cited by 10 publications

References 41 publications

Role of Cluster of Differentiation 163 in Diabetes-Periodontitis Interplay

Role of Cluster of Differentiation 163 in Diabetes-Periodontitis Interplay

Soluble CD163 as a biomarker of periodontal disease – A biochemical study using enzyme-linked immunosorbent assay

Baseline interleukin‐10, CD163, and tumor necrosis factor‐like weak inducer of apoptosis (TWEAK) gingival tissue levels in relation to clinical periodontal treatment outcomes: A 12‐week follow‐up study

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