Initial Experience With Simultaneous 18F-FDG PET/MRI in the Evaluation of Cardiac Sarcoidosis and Myocarditis

Hanneman, Kate; Kadoch, Michel; Guo, H. Henry; Jamali, Mehran; Quon, Andrew; Iagaru, Andrei; Herfkens, Robert J.

doi:10.1097/rlu.0000000000001669

Cited by 66 publications

(29 citation statements)

References 31 publications

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“…Furthermore, as the motion-compensated HD-PROST reconstruction approach provides non-rigid respiratory motion fields, the method could be extended to 3 T hybrid positron emission tomography (PET)-CMR systems for simultaneous motion-corrected cardiac PET-CMR imaging. Such an approach would be of interest for producing co-registered truly simultaneous images of myocardial inflammation by 18 F-fluorodeoxyglucose-PET and myocardial viability by 3D LGE-CMR imaging, aiding the interpretation of findings from both imaging modalities and potentially improving the diagnosis of conditions such as myocarditis and cardiac sarcoidosis [47][48][49][50].…”

Section: Discussionmentioning

confidence: 99%

Motion-corrected 3D whole-heart water-fat high-resolution late gadolinium enhancement cardiovascular magnetic resonance imaging

Muñoz

Bustin

Neji

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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Background: Conventional 2D inversion recovery (IR) and phase sensitive inversion recovery (PSIR) late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) have been widely incorporated into routine CMR for the assessment of myocardial viability. However, reliable suppression of fat signal, and increased isotropic spatial resolution and volumetric coverage within a clinically feasible scan time remain a challenge. In order to address these challenges, this work proposes a highly efficient respiratory motion-corrected 3D whole-heart water/fat LGE imaging framework. Methods: An accelerated IR-prepared 3D dual-echo acquisition and motion-corrected reconstruction framework for whole-heart water/fat LGE imaging was developed. The acquisition sequence includes 2D image navigators (iNAV), which are used to track the respiratory motion of the heart and enable 100% scan efficiency. Non-rigid motion information estimated from the 2D iNAVs and from the data itself is integrated into a high-dimensional patchbased undersampled reconstruction technique (HD-PROST), to produce high-resolution water/fat 3D LGE images. A cohort of 20 patients with known or suspected cardiovascular disease was scanned with the proposed 3D water/fat LGE approach. 3D water LGE images were compared to conventional breath-held 2D LGE images (2-chamber, 4chamber and stack of short-axis views) in terms of image quality (1: full diagnostic to 4: non-diagnostic) and presence of LGE findings. Results: Image quality was considered diagnostic in 18/20 datasets for both 2D and 3D LGE magnitude images, with comparable image quality scores (2D: 2.05 ± 0.72, 3D: 1.88 ± 0.90, p-value = 0.62) and overall agreement in LGE findings. Acquisition time for isotropic high-resolution (1.3mm 3) water/fat LGE images was 8.0 ± 1.4 min (3-fold acceleration, 60-88 slices covering the whole heart), while 2D LGE images were acquired in 5.6 ± 2.2 min (12-18 slices, including pauses between breath-holds) albeit with a lower spatial resolution (1.40-1.75 mm in-plane × 8 mm

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Section: Discussionmentioning

confidence: 99%

Motion-corrected 3D whole-heart water-fat high-resolution late gadolinium enhancement cardiovascular magnetic resonance imaging

Muñoz

Bustin

Neji

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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“…direct interrogation of infiltrating immune cells on a subcellular level 7 . Consequently, the combination of PET and MRI could provide incremental information about myocardial injury and inflammatory activity: in a small cohort of ten patients, simultaneous PET/MRI using 18 F-FDG was feasible to diagnose both cardiac sarcoidosis and myocarditis 36 . Thus, such an imaging approach could also potentially be applied in the herein presented experimental setting.…”

Section: Discussionmentioning

confidence: 94%

Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis

Werner

Wakabayashi

Bauer

et al. 2018

European Heart Journal - Cardiovascular Imaging

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“…It is also encouraging that a relevant multimodality imaging approach is under investigation for these two disease entities, especially PET-magnetic resonance (MR) [80,90,91]. Excellent morphological evidence and tissue characterization are expected to have a synergistic effect with PET.…”

Section: Resultsmentioning

confidence: 99%

Emerging Tracers for Nuclear Cardiac PET Imaging

Kim

Cho

Bom

2018

Nucl Med Mol Imaging

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Myocardial perfusion imaging using positron emission tomography (PET) has several advantages over single photon emission computed tomography (SPECT). The recent advances in SPECT technology have shown promise, but there is still a large need for PET in the clinical management of coronary artery disease (CAD). Especially, absolute quantification of myocardial blood flow (MBF) using PET is extremely important. In spite of considerable advances in the diagnosis of CAD, novel PET radiopharmaceuticals remain necessary for the diagnosis of CAD because clinical use of current cardiac radiotracers is limited by their physical characteristics, such as decay mode, emission energy, and half-life. Thus, the use of a radioisotope that has proper characteristics and a proper half-life to develop myocardial perfusion agents could overcome these limitations. In this review, the current state of cardiac PET and a general overview of novel F orGa-labeled radiotracers, including their radiosynthesis, in vivo characterization, and evaluation, are provided. The future perspectives are discussed in terms of their potential usefulness based on new image analysis methods and hybrid imaging.

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Initial Experience With Simultaneous 18F-FDG PET/MRI in the Evaluation of Cardiac Sarcoidosis and Myocarditis

Abstract: Simultaneous cardiac PET/MRI is feasible in the evaluation of cardiac sarcoidosis and myocarditis achieving diagnostic image quality.

Cited by 66 publications

References 31 publications

Motion-corrected 3D whole-heart water-fat high-resolution late gadolinium enhancement cardiovascular magnetic resonance imaging

Motion-corrected 3D whole-heart water-fat high-resolution late gadolinium enhancement cardiovascular magnetic resonance imaging

Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis

Emerging Tracers for Nuclear Cardiac PET Imaging

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