Synthesis and characterization of cycloaliphatic hydrophilic polyurethanes, modified with l -ascorbic acid, as materials for soft tissue regeneration

Kucińska-Lipka, Justyna; Gubańska, Iga; Strankowski, Michał; Cieśliński, Hubert; Filipowicz, Natalia; Janik, Helena

doi:10.1016/j.msec.2017.02.052

Cited by 35 publications

(28 citation statements)

References 54 publications

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“…The very strong carbonyl stretching, in the case of obtained TPUs and nanocomposite systems, appeared at 1726 cm −1 . The FTIR analysis confirmed that the performed synthesis lead to the generation of obtain TPUs [ 58 ].…”

Section: Resultsmentioning

confidence: 73%

Morphology, Mechanical and Thermal Properties of Thermoplastic Polyurethane Containing Reduced Graphene Oxide and Graphene Nanoplatelets

et al. 2018

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Polyurethane/graphene nanocomposites were synthesized using commercial thermoplastic polyurethane (TPU, Apilon 52DE55), and two types of graphene derivatives: graphene nanoplatelets (GNP) and reduced graphene oxide (RGO). Fourier Transformation Infrared Spectroscopy Fourier Transformation Infrared Spectroscopy (FTIR) spectroscopy, TEM, and SEM microscopy and XRD techniques were used to chemically and structurally characterize GNP and RGO nanofillers. The properties of the new TPU nanocomposite materials were studied using thermal analysis techniques (Dynamical Mechanical Analysis (DMA), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TG)) to describe the influence of graphene nanofillers on polyurethane matrix. Our investigation describes the comparison of two types of graphene derivatives, commercial one (GNP) and synthesized (RGO) on thermoplastic polyurethanes. These nanofillers provides opportunities to achieve compatibility with the TPU matrix. The property enhancements are attributed commonly to high aspect ratio of graphene nanoplatelets and filler–polymer interactions at the interface. The obtained nanocomposites exhibit higher thermal and mechanical properties due to the good dispersion of both nanofillers into TPU matrix. It was found that the addition of 2 wt % of the nanofiller could lead to a significant reinforcement effect on the TPU matrix. Also, with high content of nanofiller (GNP and RGO), the Payne effect was observed.

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Section: Resultsmentioning

confidence: 73%

Morphology, Mechanical and Thermal Properties of Thermoplastic Polyurethane Containing Reduced Graphene Oxide and Graphene Nanoplatelets

et al. 2018

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“…At the end of the study, however, yellowing of the sample was noticed ( Table S6 ), most likely due to accumulation on the sample surface of salt deposits. Nevertheless, the stability of TPU_P, under PBS incubation conditions, corresponds to the requirements set for structures intended, for instance for tissue engineering application [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering

et al. 2020

Self Cite

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This paper addresses the potential of self-made polyester-urethane filament as a candidate for Fused Filament Fabrication (FFF)-based 3D printing (3DP) in medical applications. Since the industry does not provide many ready-made solutions of medical-grade polyurethane filaments, we undertook research aimed at presenting the process of thermoplastic polyurethane (TPU) filament formation, detailed characteristics, and 3DP of specially designed elastic porous structures as candidates in cancellous tissue engineering. Additionally, we examined whether 3D printing affects the structure and thermal stability of the filament. According to the obtained results, the processing parameters leading to the formation of high-quality TPU filament (TPU_F) were captured. The results showed that TPU_F remains stable under the FFF 3DP conditions. The series of in vitro studies involving long- and short-term degradation (0.1 M phosphate-buffered saline (PBS); 5 M sodium hydroxide (NaOH)), cytotoxicity (ISO 10993:5) and bioactivity (simulated body fluid (SBF) incubation), showed that TPU printouts possessing degradability of long-term degradable tissue constructs, are biocompatible and susceptible to mineralization in terms of hydroxyapatite (HAp) formation during SBF exposure. The formation of HAp on the surface of the specially designed porous tissue structures (PTS) was confirmed by scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDS) studies. The compression test of PTS showed that the samples were strengthened due to SBF exposure and deposited HAp on their surface. Moreover, the determined values of the tensile strength (~30 MPa), Young’s modulus (~0.2 GPa), and compression strength (~1.1 MPa) allowed pre-consideration of TPU_F for FFF 3DP of cancellous bone tissue structures.

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“…S-TPU was synthesized by standard two-step polymerization procedure ( Figure 1) [25]. It was derived from amorphous PEBA (in contrary to PUR synthesized by using crystalline oligodiols [37,38]), aliphatic HDI and BDO chain extender.…”

Section: S-tpu Synthesismentioning

confidence: 99%

“…Materials that may be alternative to medical filaments based on PCL and PLA are properly designed thermoplastic polyurethanes (TPUs). According to the literature, they exhibit biocompatibility and hemocompatibility [25]. Moreover, TPU degradation rate can be controlled as well [26].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology

Haryńska¹,

Gubańska²,

Kucińska-Lipka³

et al. 2018

Preprint

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The possibility of using additive manufacturing (AM) in the medicine area has created a new opportunities in health care. This has contributed to a sharp increase in demand for 3D printers, their systems and materials that are adapted to strict medical requirements. We described herein a medical-grade thermoplastic polyurethane (S-TPU), which was developed and then formed into a filament for Fused Deposition Modeling (FDM) 3D printers during a melt-extrusion process. S-TPU consisting of aliphatic hexamethylene 1,6-diisocyanate (HDI), amorphous α,ω-dihydroxy(ethylene-butylene adipate) (PEBA) and 1,4 butandiol (BDO) as a chain extender, was synthesized without the use of a catalyst. The filament properties were characterized by rheological, mechanical, physico-chemical and in vitro biological properties. The tests showed biocompatibility of the obtained filament as well as revealed no significant effect of the filament formation process on its properties. This study may contribute to expanding the range of medical-grade flexible filaments for standard low-budget FDM printers.

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Synthesis and characterization of cycloaliphatic hydrophilic polyurethanes, modified with l -ascorbic acid, as materials for soft tissue regeneration

Cited by 35 publications

References 54 publications

Morphology, Mechanical and Thermal Properties of Thermoplastic Polyurethane Containing Reduced Graphene Oxide and Graphene Nanoplatelets

Morphology, Mechanical and Thermal Properties of Thermoplastic Polyurethane Containing Reduced Graphene Oxide and Graphene Nanoplatelets

Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering

Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology

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