Modeling the spread of avian influenza viruses in aquatic reservoirs: A novel hydrodynamic approach applied to the Rhône delta (southern France)

Vittecoq, Marion; Gauduin, Hermann; Oudart, Thibault; Bertrand, Olivier; Roche, Benjamín; Guillemain, Matthieu; Boutron, Olivier

doi:10.1016/j.scitotenv.2017.03.165

Cited by 13 publications

(8 citation statements)

References 39 publications

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“…The putative role of particle persistence in the environment for IAV transmission has been discussed in reviews ( Weber and Stilianakis, 2008 ; Sooryanarain and Elankumaran, 2015 ). Using computational approaches, it was suggested that the virus persistence in the environmental reservoir is an important parameter impacting overwintering of IAVs, infection probability of migratory ducks in low density population areas as well as spatial variations of IAV spreading ( Lang et al, 2008 ; Roche et al, 2014 ; Vittecoq et al, 2017 ). IAVs persistence could also explain their evolutionary dynamic.…”

Section: Discussionmentioning

confidence: 99%

Influenza Virus Segment Composition Influences Viral Stability in the Environment

et al. 2018

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The transmission routes of Influenza A viruses (IAVs) submit virus particles to a wide range of environmental conditions that affect their transmission. In water, temperature, salinity, and pH are important factors modulating viral persistence in a strain-dependent manner, and the viral factors driving IAV persistence remain to be described. We used an innovative method based on a real-time cell system analysis to quantify viral decay in an environmental model. Thus, we identified the viral hemagglutinin (HA) and neuraminidase (NA) as the main proteins driving the environmental persistence by comparing the inactivation slopes of several reassortant viruses. We also introduced synonymous and non-synonymous mutations in the HA or in the NA that modulated IAV persistence. Our results demonstrate that HA stability and expression level, as well as calcium-binding sites of the NA protein, are molecular determinants of viral persistence. Finally, IAV particles could not trigger membrane fusion after environmental exposure, stressing the importance of the HA and the NA for environmental persistence.

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Section: Discussionmentioning

confidence: 99%

Influenza Virus Segment Composition Influences Viral Stability in the Environment

et al. 2018

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“…Studies of disruptions in mallard migration have shown that changes in the environment—at start point and throughout the journey—can affect overall movement and direction (van Toor et al, 2013) interrupting their normal migratory route (Kleyheeg et al, 2019; Tolf et al, 2012). The transfer of H1N1 influenza virus from animals (avian and mammals) to humans (zoonosis) occurs primarily via water sources contaminated with fecal droppings from infected birds (Breban et al, 2009; Carter & Sanford, 2012; Pawar et al, 2018; Vandegrift et al, 2010; Vittecoq et al, 2017; Worobey et al, 2014). In autumn, the rate of influenza A viral infection can be as high as 60% in mallard populations, due to the exposure of immunologically naïve juveniles to the virus (Bengtsson et al, 2016; Tolf et al, 2012).…”

Section: Main Textmentioning

confidence: 99%

The Impact of a Six‐Year Climate Anomaly on the “Spanish Flu” Pandemic and WWI

Loveluck

Clifford

et al. 2020

GeoHealth

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The H1N1 "Spanish influenza" pandemic of 1918-1919 caused the highest known number of deaths recorded for a single pandemic in human history. Several theories have been offered to explain the virulence and spread of the disease, but the environmental context remains underexamined. In this study, we present a new environmental record from a European, Alpine ice core, showing a significant climate anomaly that affected the continent from 1914 to 1919. Incessant torrential rain and declining temperatures increased casualties in the battlefields of World War I (WWI), setting the stage for the spread of the pandemic at the end of the conflict. Multiple independent records of temperature, precipitation, and mortality corroborate these findings. Plain Language Summary A new, high-resolution climate record from Europe shows a once-in-a-century climate anomaly that occurred during the years of World War I and the Spanish flu pandemic. Mortality data from all causes show increases in times of worsening weather, precipitation, and temperatures, a factor in many of the major battles of WWI, as well as a possible exacerbating factor for the virulence of the pandemic.

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“…Models suggest that environmental reservoirs play an important role in the ecology of IAVs because they allow infection between hosts that infrequently come into direct contact, such as migratory wild waterfowl on breeding grounds [13,14,23,24]. Experimental systems have shown the occurrence of environmental transmission of IAVs among reservoir hosts and from reservoir hosts to spillover hosts [25][26][27][28].…”

Section: (B) Environmental Transmissionmentioning

confidence: 99%

Improving risk assessment of the emergence of novel influenza A viruses by incorporating environmental surveillance

Pepin

Hopken

Shriner

et al. 2019

Phil. Trans. R. Soc. B

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Reassortment is an evolutionary mechanism by which influenza A viruses (IAV) generate genetic novelty. Reassortment is an important driver of host jumps and is widespread according to retrospective surveillance studies. However, predicting the epidemiological risk of reassortant emergence in novel hosts from surveillance data remains challenging. IAV strains persist and co-occur in the environment, promoting co-infection during environmental transmission. These conditions offer opportunity to understand reassortant emergence in reservoir and spillover hosts. Specifically, environmental RNA could provide rich information for understanding the evolutionary ecology of segmented viruses, and transform our ability to quantify epidemiological risk to spillover hosts. However, significant challenges with recovering and interpreting genomic RNA from the environment have impeded progress towards predicting reassortant emergence from environmental surveillance data. We discuss how the fields of genomics, experimental ecology and epidemiological modelling are well positioned to address these challenges. Coupling quantitative disease models and natural transmission studies with new molecular technologies, such as deep-mutational scanning and single-virus sequencing of environmental samples, should dramatically improve our understanding of viral co-occurrence and reassortment. We define observable risk metrics for emerging molecular technologies and propose a conceptual research framework for improving accuracy and efficiency of risk prediction. This article is part of the theme issue ‘Dynamic and integrative approaches to understanding pathogen spillover’.

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Modeling the spread of avian influenza viruses in aquatic reservoirs: A novel hydrodynamic approach applied to the Rhône delta (southern France)

Cited by 13 publications

References 39 publications

Influenza Virus Segment Composition Influences Viral Stability in the Environment

Influenza Virus Segment Composition Influences Viral Stability in the Environment

The Impact of a Six‐Year Climate Anomaly on the “Spanish Flu” Pandemic and WWI

Improving risk assessment of the emergence of novel influenza A viruses by incorporating environmental surveillance

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