Ethnic differences in association of high body mass index with early onset of Type 1 diabetes – Arab ethnicity as case study

Channanath, Arshad; Elkum, Naser; Al‐Abdulrazzaq, Dalia; Tuomilehto, Jaakko; Shaltout, Azza; Thanaraj, Thangavel Alphonse

doi:10.1371/journal.pone.0175728

Cited by 4 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 Ethnic variations for cut off values for BMI classes are also emphasized. 1,9 Calorie intake became twice in last 25 years according to Bangladesh National Survey. 10 Calorie intake was 1707 Kcal in 1976-77 and increased to 2344 KCal in 2010.…”

Section: Resultsmentioning

confidence: 99%

Body Mass Index: Where We Will Go by The Year 2030!

2018

View full text Add to dashboard Cite

Background: The prevalence of diabetes mellitus is increasing throughout the world, mostly type 2 diabetes mellitus and largely contributed by increasing body mass index (BMI). This study was designed to compare BMI of newly detected diabetic patients in two different Bangladeshi cohorts spaced over 25 years.Methods: This was a retrospective study from hospital records from two cohorts: 1981 to 1985 and 2006 to 2010. Patients were divided in 4 groups according to BMI and comparison was made. BMI of newly detected diabetic patients from 2011 and 2012 were also compared.Results: Age at diagnosis of diabetes was lower in 2006-2010 group than 1981-1985 group. Frequency of diabetes at lower BMI has fallen by half in 2006-2010 group when compared with those of 1981-1985 group. Frequency of diabetes at higher BMI groups has an increasing trend in 2006-2010 group than in 1981-1985 group.Conclusion: Results from this study concludes that there is an increasing trend of diabetes detection at lower age group and with higher BMI among Bangladeshi population.Birdem Med J 2018; 8(2): 99-102

show abstract

Section: Resultsmentioning

confidence: 99%

Body Mass Index: Where We Will Go by The Year 2030!

2018

View full text Add to dashboard Cite

show abstract

“…Interestingly, the authors pointed to a slightly higher incidence rate in overweight, but not in obese children ( 14 ). Attempts to include additional ethnic factors showed that the accelerator hypothesis is not universal ( 15 ). Interestingly, we found that BMI-SDS was significantly higher in the older age groups.…”

Section: Discussionmentioning

confidence: 99%

“…This theory has been confirmed by some studies strongly supporting the association between BMI and earlier diagnosis of type 1 diabetes ( 6 , 9 , 10 , 11 ). Nevertheless, it is not universally accepted, as there are other studies that have contradicted these findings and do not support such a relationship ( 12 , 13 , 14 , 15 ). The starting point for the current study was a significant increase in the incidence of type 1 diabetes in the young age groups in the Lesser Poland region (from 5.2/100,000/year in 1987 to 21.9/100,000/year in 2012), which was demonstrated in our previous paper ( 16 ).…”

Section: Introductionmentioning

confidence: 90%

Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?

Wasyl-Nawrot¹,

Wójcik²,

Nazim³

et al. 2020

Jcrpe

View full text Add to dashboard Cite

Objective: One of the hypothesized reasons for the observed increase in type 1 diabetes incidence in children is weight gain, causing accelerated disease development in predisposed individuals. This so-called accelerator hypothesis is, however, controversial. The aim was to analyze whether, in the ethnically homogeneous population of Lesser Poland, an increase in the number of cases of diabetes among children was associated with younger age and higher body mass index-standard deviation score (BMI-SDS) at the time of diagnosis. Methods: Retrospective data analysis from medical records of all patients <14 years (n=559; 50.6% male), with newly diagnosed type 1 diabetes, in Lesser Poland between 1 st January 2006 and 31 st December 2017 (11 years). Results: The incidence ratio ranged significantly (p<0.001) from the lowest in 2006 (11.2/100,000/year) to the highest in 2012 (21.9/100,000/year). The mean age of diagnosis was 8.2±3.5 years. There was no trend in decreasing diagnosis age (p=0.43). The mean BMI-SDS was -0.4±1.2. Almost all children (91.6%) presented with BMI-SDS within the normal range at the time of diagnosis, with only 2.7% of cases being obese and 5.7% underweight at the moment of diagnosis. There was no clear trend at all in BMI-SDS over the study period. Conclusion: These results do not corroborate an increase of type 1 incidence in paediatric population being associated with younger age of diagnosis and higher BMI-SDS. This implies that the accelerator hypothesis does not hold true in the study population.

show abstract

“…The recent study from Kuwait does indicate that ethnic differences in patient populations may explain the association between BMI and age at diagnosis. 15 In order to truly test the relevance of AH, there is a need to conduct prospective worldwide studies in ethnically diverse patient populations with a focus similar to adAPT. That will be a true tribute to a legend who sought to challenge some of the major doctrines in endocrinology during his lifetime.…”

Section: The Future Of Ahmentioning

confidence: 99%

Brakes on the accelerator: the journey of accelerator hypothesis from “the missing link” to “an evolving concept”

Dayal

Muthuvel

2017

Int J Sci Rep

View full text Add to dashboard Cite

CONTEXTThe accelerator hypothesis (AH) proposed by the late Prof Terence Wilkin attempts to unite the type 1 (T1D) and type 2 diabetes (T2D) by obesity driven insulin resistance (IR) and tends, in part, to explain the rising incidence of T1D by a parallel increase in the incidence of obesity.1 Since its inception in 2001, several studies have been conducted across the world to test the validity of AH. The results of these studies have shown considerable variability with some studies confirming and others refuting or showing neutrality to the key proposals of AH. This brief communication discusses the journey of AH over the last 16 years in the light of data accumulated from studies that aimed to test relevance and applicability of AH in diverse patient populations. KEY PREDICTIONS AND CONTROVERSIESThe AH proposes that all the three processes or accelerators i.e. IR, autoimmunity and genetic predisposition that result in presentation of diabetes (either type 1 or 2) are driven by excess weight gain, which is thought to be "the missing link" between the two types of diabetes.1 In particular, IR associated with recent weight gain is considered the main accelerator of pancreatic β-cell apoptosis that leads to earlier onset of T1D in individuals at genetic risk. The acceleration of diabetes and its presentation at a younger age will, ABSTRACTThe incidence of Type 1 diabetes (T1D) has increased significantly over the past few decades but the causes for this increase are poorly understood and hence the strategies for preventing T1D are difficult to design. T1D is characterised by autoimmune destruction of pancreatic β-cells resulting in insulin deficiency as opposed to Type 2 diabetes (T2D) characterised by weight driven insulin resistance (IR). The accelerator hypothesis (AH), proposed by the late Prof Terence Wilkin in 2001 offers an alternative mechanism for T1D and a different approach to prevention of T1D. This hypothesis considers both T1D and T2D as one and proposes that obesity driven IR is the key factor that may lead to either type of diabetes. It thus offers an easy explanation for the increasing worldwide incidence of childhood diabetes which is paralleled by the increase in childhood obesity rates. However, one of the key predictions of AH that the obesity related IR accelerates the onset of diabetes and hence heavier children should develop diabetes at a younger age, has remained a matter of debate since the hypothesis was first proposed. Since the inception of AH, the results of a number of studies which aimed at testing the hypothesis in diverse patient populations have shown support or opposed this key prediction. This article discusses the relevance of AH in the context of data from these studies.

show abstract

Ethnic differences in association of high body mass index with early onset of Type 1 diabetes – Arab ethnicity as case study

Cited by 4 publications

References 40 publications

Body Mass Index: Where We Will Go by The Year 2030!

Body Mass Index: Where We Will Go by The Year 2030!

Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?

Brakes on the accelerator: the journey of accelerator hypothesis from “the missing link” to “an evolving concept”

Contact Info

Product

Resources

About