“…Similarly, oncogene activated AT2s show disorganized apical domains, increasingly becoming unipolar at later stages, suggesting that the multi-apical polarity of AT2s is dynamically regulated in normal as well as disease states. Indeed, genetic mutations or altered expression of MUC1 has been implicated in lung cancer growth, metastasis, and chemotherapy resistance ( Bouillez et al., 2016 ; Ham et al., 2016 ; Horimasu et al., 2017 ; Raina et al., 2011 ; Saltos et al., 2018 ). In sum, our study has uncovered a unique multi-apical polarity of an epithelial cell type and its dynamics during development, injury repair, and tumorigenesis.…”