Association of inflammatory genes with neuroticism, anxiety and depression in male patients with coronary heart disease

Голимбет, В. Е.; Volel, B. A.; Коровайцева, Г. И.; Kasparov, S. V.; Kondratiev, N. V.; Kopylov, F. Yu.

doi:10.17116/jnevro20171173174-79

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Russian researchers report that −174G/C polymorphism was associated with depression comorbid to coronary heart disease. The frequency of the allele G in this group was higher compared with controls [41]. The polymorphic variant rs1800795 (IL6-174G/C) is associated with recent stress on current depressive symptoms and is associated with lifetime depression at a nominal significance level [41].…”

Section: Santos Et Al (2016) [50]mentioning

confidence: 71%

Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder

Mikhalitskaya

Vyalova

Ermakov

et al. 2023

Genes

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Immune gene variants are known to be associated with the risk of psychiatric disorders, their clinical manifestations, and their response to therapy. This narrative review summarizes the current literature over the past decade on the association of polymorphic variants of cytokine genes with risk, severity, and response to treatment for severe mental disorders such as bipolar disorder, depression, and schizophrenia. A search of literature in databases was carried out using keywords related to depressive disorder, bipolar disorder, schizophrenia, inflammation, and cytokines. Gene lists were extracted from publications to identify common genes and pathways for these mental disorders. Associations between polymorphic variants of the IL1B, IL6, and TNFA genes were the most replicated and relevant in depression. Polymorphic variants of the IL1B, IL6, IL6R, IL10, IL17A, and TNFA genes have been associated with schizophrenia. Bipolar disorder has mainly been associated with polymorphic variants of the IL1B gene. Interestingly, the IL6R gene polymorphism (rs2228145) was associated with all three diseases. Some cytokine genes have also been associated with clinical presentation and response to pharmacotherapy. There is also evidence that some specific polymorphic variants may affect the expression of cytokine genes. Thus, the data from this review indicate a link between neuroinflammation and severe mental disorders.

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Section: Santos Et Al (2016) [50]mentioning

confidence: 71%

Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder

Mikhalitskaya

Vyalova

Ermakov

et al. 2023

Genes

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“…Genetic studies have postulated that higher neuroticism score causes anxiety and other psychological disorders. [36][37][38][39] Hettema et al performed the largest population-based twin study on this topic to date. They gauged data from over 9000 male and female twins, discovered 40-50% genetic correlations between neuroticism and anxiety disorders with low environmental correlations, concluding that the association between neuroticism and anxiety disorder is essentially caused by their mutual genetic factors.…”

Section: Discussionmentioning

confidence: 99%

Does Personality and Anxiety Symptomatology Matter in the Diabetes Mellitus Treatment Adherence? A Cross-Sectional Study Among Women with Diabetes Mellitus.

Woon

Singh

Sidi

2021

imjm

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Abstract Purpose: Anxiety is prevalent among women with diabetes mellitus. Women also tend to have higher levels of neuroticism and anxiety. These symptoms can have an impact on social functioning and diabetes care. The main aim of the present study was to determine the relationship between neuroticism and anxiety symptoms, and other clinical and psychosocial variables, among women with diabetes mellitus (DM). Patients and methods: This was a cross-sectional study conducted on women with diabetes mellitus. Sociodemographic and clinical variables were acquired, including perceptions on religious practice, social support, and diabetic self-care. Study subjects completed the Generalized Anxiety Disorder 7-item (GAD-7) and the Big-Five Inventory (BFI). The neuroticism subscale of the BFI was used for analysis. Results: The study included 141 subjects (Median age: 64.0 years, IQR: 52.5–71.0 years) with a median duration of diabetes of 12.0 years (IQR: 6.0–20.0 years). Neuroticism scores correlated positively with the GAD-7 scores (Spearman’s rho: 0.406; p<0.001). In the bivariate analysis, neuroticism also had significant association with employment status (p=0.023), religious practice (p=0.006), perceived social support (p=0.001), and perceived ability of diabetic self-management (p<0.001). In the regression analysis, after controlling for employment, religious practice, and social support, neuroticism remained associated with anxiety (p<0.001) and diabetic self-management (p=0.001). Conclusions: Neuroticism was related to poorer subjective sense of diabetic management and a greater level of anxiety among women with DM. Improving self-efficacy in managing diabetes may help patients coping up with anxiety symptoms among those with neuroticism traits. This may also contribute to a better understanding of features and effective treatment of women with DM.

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“…However, inflammation is the main driver of these pathological processes. Patients with CHD and comorbid depression have elevated levels of pro-inflammatory cytokines in the circulating blood, including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α (7). Peripheral innate and adaptive immune molecule activation can interact with the central nervous, immune system (8).…”

Section: Introductionmentioning

confidence: 99%

Identification of genes and pathways related to atherosclerosis comorbidity and depressive behavior via RNA-seq and bioinformation analysis in ApoE−/− mice

Zhou¹,

Zhang²,

Wu³

et al. 2019

Ann Transl Med

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Background: Depression is an independent risk factor for atherosclerosis (AS), which can increase the risk of death and disability from AS. However, the mechanism of AS comorbidity with depression is complex.Methods: ApoE −/− and C57BL/6J mice were fed with a high-fat diet (model group, N=12 ♂) and a normal diet (control group, N=12 ♂). During the 15-week experimental period, the following tests were performed: coat color score, body weight, and sucrose preference tests (every 2 weeks); open-field test (1 st , 7 th , and 15 th weeks); and light/dark and tail suspension tests (15 th week). Oil Red O and hematoxylin and eosin (HE) stainings were used to assess the area of atherosclerotic status. The levels of triglyceride and total and low-density lipoprotein cholesterol in the serum and secretion of pro-inflammatory cytokines were determined using the enzyme-linked immunosorbent assay. The differentially expressed genes (DEGs) in the hippocampus and prefrontal cortex were screened by RNA-sequencing (RNA-seq) and analyzed using the Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) annotations.Results: Our findings showed that compared with C57 mice in the control group, ApoE −/− mice in the model group gradually developed depression-like behavioral changes with elevated blood lipid concentrations, serum inflammatory factor levels, and atherosclerotic plaque formation in the thoracic aorta.Consequently, in the RNA-seq and bioinformatics analysis, the high expression of inflammatory chemokine genes was found in the hippocampus and prefrontal cortex area. The regulation of movement, feeding, and reproduction of the gene expression decreased.Conclusions: These results indicate that when ApoE −/− mice were fed a high-fat diet for 15 weeks, depression-like behavioral changes occurred with the formation of atherosclerotic lesions. The RNAseq, combined with bioinformatics analysis, showed that this AS comorbidity with depressive behavior was associated with the high expression of inflammation-related genes and pathways in the hippocampus and prefrontal cortex.

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Association of inflammatory genes with neuroticism, anxiety and depression in male patients with coronary heart disease

Abstract: The finding of the association between the IL-6 -174G/C and depression, comorbid to CHD, is in line with literature on a role of IL-6 in the development of depression in patients with CHD.

Cited by 5 publications

References 28 publications

Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder

Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder

Does Personality and Anxiety Symptomatology Matter in the Diabetes Mellitus Treatment Adherence? A Cross-Sectional Study Among Women with Diabetes Mellitus.

Identification of genes and pathways related to atherosclerosis comorbidity and depressive behavior via RNA-seq and bioinformation analysis in ApoE−/− mice

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