2017
DOI: 10.4067/s0716-10182017000100001
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Factores asociados a nefrotoxicidad por polimixina B en un hospital universitario de Neiva, Colombia. 2011-2015

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Cited by 14 publications
(11 citation statements)
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“…In fact, overall AKI rates were similar to the average rate of 40% found in previous studies of PMB (range, 20% to 60%) (27)(28)(29)(30)(31)(32)(33)(34). The proportion of patients with renal failure in our study might be considered higher (46.3% of patients with AKI) than that described in reports of previous studies, which presented an average proportion of patients with renal failure of approximately 22% (but the average proportion ranged widely from 4% to 50%) (27)(28)(29)(30)(31)(32)(33)(34), and the onset of failure may have occurred earlier in our sample than patients in previous studies. The number of patients requiring renal replacement therapy in our cohort may also be considered high, potentially indicating a higher risk for more severe kidney damage in patients receiving these high doses, although a definitive conclusion requires a proper control group exposed to lower doses.…”
Section: Discussionsupporting
confidence: 87%
“…In fact, overall AKI rates were similar to the average rate of 40% found in previous studies of PMB (range, 20% to 60%) (27)(28)(29)(30)(31)(32)(33)(34). The proportion of patients with renal failure in our study might be considered higher (46.3% of patients with AKI) than that described in reports of previous studies, which presented an average proportion of patients with renal failure of approximately 22% (but the average proportion ranged widely from 4% to 50%) (27)(28)(29)(30)(31)(32)(33)(34), and the onset of failure may have occurred earlier in our sample than patients in previous studies. The number of patients requiring renal replacement therapy in our cohort may also be considered high, potentially indicating a higher risk for more severe kidney damage in patients receiving these high doses, although a definitive conclusion requires a proper control group exposed to lower doses.…”
Section: Discussionsupporting
confidence: 87%
“…Asimismo, se determinó que la IHQ de tipo órgano espacio es un factor asociado a la letalidad, similar a lo encontrado por Horasan et al 18 . La letalidad en este tipo de infecciones sobreviene por la ubicación en sitios anatómicos complejos y con irrigación comprometida, que hacen dispendiosa la penetración del antibiótico, máxime cuando un gran número de estas infecciones son producidas por gérmenes multirresistentes que presentan una elevada letalidad 37,38 , principalmente debido a la utilización de medicamentos que producen efectos adversos serios 39 .…”
Section: Discussionunclassified
“…Due to the difficult to treat nature of infections caused by carbapenem-producing K. pneumoniae (CpKP), there are limited treatment options that are currently available. Studies have reported that antibiotics such as colistin, gentamicin, tigecycline, and fosfomycin that are used for the treatment of infections caused by CpKP can lead to severe adverse effects such as nephrotoxicity ( Akajagbor et al, 2013 ; Osorio et al, 2017 ) and hepatotoxicity ( Lim et al, 2010 ; Florescu et al, 2012 ). According to ( Tumbarello et al, 2012a ; Daikos et al, 2014 ), it has been reported that during bacteremic infections, combination treatment regimens are recommended; however, it has been reported by Gutiérrez-Gutiérrez et al (2017) that, combination therapies should be used when patients are in critical conditions.…”
Section: Introductionmentioning
confidence: 99%