Comparison of in vivo vs. frozen vs. Thiel cadaver specimens in visualisation of anatomical structures of the ankle on proton density Magnetic Resonance Imaging (MRI) through a visual grading analysis (VGA) study

Zarb, Francis; McNulty, Jonathan P.; Gatt, Alfred; Formosa, Cynthia; Chockalingam, Nachiappan; Evanoff, Michale G.; Rainford, Louise

doi:10.1016/j.radi.2016.12.004

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…Opposite to that Giannini et al [14] noted an increased CSA in the fresh-frozen tendons of the posterior tibial muscles as well as increased stiffness and decreased ultimate load. An interesting study was performed by Zarb et al [46] who analyzed the quality of the Magnetic Resonance (MR) images of a live patients', fresh-frozen and Thiel embalmed bones, ligaments, tendons and muscles of the ankle. The image quality of the fresh-frozen specimen appeared to be higher when compared to the live patient.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the histological structure of the tibial nerve and its terminal branches in the fresh and fresh-frozen cadavers

et al. 2021

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Background: The aim of this study was to compare the histological structure (cross-sectional area (CSA) and number of nerve fascicles) of the distal part of the tibial nerve (TN) and its terminal branches (medial plantar nerve [MPN], lateral plantar nerve [LPN]) in the fresh and fresh-frozen cadavers using computer assisted image analysis. Materials and methods: The tibial nerve with terminal branches (medial and lateral plantar nerves) were dissected from the fresh and fresh-frozen cadavers. Each nerve was harvested 5 mm proximally and respectively 5 mm distally from the tibial nerve bifurcation, marked, dehydrated, embedded in paraffin, sectioned at 2 µm slices and stained with haematoxylin and eosin. Then the specimens were photographed and analyzed using Olympus cellSens software. Results: The fresh cadavers group comprised 60 feet (mean age 68.1 ± 15.2 years). The mean CSA and the number of nerve fascicles were respectively 15.25 ± 4.6 mm 2 , 30.35 ± 8.45 for the tibial nerve, 8.76 ± 1.93 mm 2 , 20.75 ± 7.04 for the medial plantar nerve and 6.54 ± 2.02 mm 2 , 13.40 ± 5.22 for the lateral plantar nerve. The fresh-frozen cadavers group comprised 21 feet (mean age 75.1 ± 9.0 years). The mean CSA and the number of nerve fascicles were respectively 13.71 ± 5.66 mm 2 , 28.57 ± 8.00 for the tibial nerve, 7.55 ± 3.25 mm 2 , 18.00 ± 6.72 for the medial plantar nerve and 4.29 ± 1.93 mm 2 , 11.33 ± 1.93 for the lateral plantar nerve. Only lateral plantar nerves showed statistical differences in the CSA and the number of nerve fascicles between examined groups (p = 0.000, p = 0.037 respectively). A positive correlation was found between donors age and tibial nerve CSA in the fresh cadavers group (r = 0.44, p = 0.000). A statistical difference was found between the medial and lateral plantar nerves both in the CSA and the number of nerve fascicles (p < 0.001, p < 0.001 respectively). Conclusions: The CSA and the number of nerve fascicles of the tibial and medial plantar nerves were similar in the fresh and fresh-frozen cadavers whilst different in the lateral plantar nerve. The tibial nerve showed increasing CSA with the advanced age in the fresh cadavers. The medial plantar nerve had larger CSA and more nerve fascicles than the lateral plantar nerve.

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Section: Discussionmentioning

confidence: 99%

Comparison of the histological structure of the tibial nerve and its terminal branches in the fresh and fresh-frozen cadavers

et al. 2021

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“…The strength of FFC is especially emphasized as it is considered very similar to actual patients' bodies and can imitate an operation situation (Aoyama et al, 2019). However, there were also areas that showed little or no significant difference with other cadaveric methods, especially with Thiel‐fixed cadavers such as mechanical testing of hard tissue (Zech et al, 2006; Gilbody et al, 2011; Zarb et al, 2017; Gatt et al, 2019). In addition, Thiel‐fixed cadavers have strength with relatively little effect of dehydration compared with FFC (Beger et al, 2020; Verstraete et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Current and potential use of fresh frozen cadaver in surgical training and anatomical education

Song

2022

Anatomical Sciences Ed

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Anatomy functions as the basic discipline of undergraduate medical education and is an essential part of surgical training (Sotgiu et al., 2020). The center of anatomical education is dissection. The importance of dissection courses for both medical students and surgical trainees has been emphasized by numerous studies for many reasons (Korf et al., 2008;Khan & Mirza, 2013;Riederer, 2016). These reasons include the need for actual touching of bodies, visualizing the structures of connected tissues, and enhancing ethics (Korf et al., 2008;Naz et al., 2017).For these reasons, most medical schools worldwide have implemented a cadaver-based curriculum (Habicht et al., 2018). As the need for cadavers has been consistent, various methods and technologies for preserving human cadavers have been studied. This has provided medical schools with numerous models of cadavers that can be chosen for their dissection courses (Brenner, 2014;Hayashi et al., 2016). Most of the developed preparation

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“…In regards to MR parameters, perfusion usually accounts for the biggest differences between in-vivo and ex-vivo situations, and as ligaments are not considerably perfused, the MR parameters are expected to change less between in-vivo and ex-vivo situations. Moreover, as shown by Zarb et al (2017), although in-vivo MRI provide a better quality cadaveric MR images can confidently be used for also anatomical assessments (e.g. ligament volume) (Zarb, 2017).…”

Section: Tablementioning

confidence: 99%

A noninvasive MRI based approach to estimate the mechanical properties of human knee ligaments

Beidokhti

Mazzoli

Gijsbertse³

et al. 2019

Journal of the Mechanical Behavior of Biomedical Materials

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Comparison of in vivo vs. frozen vs. Thiel cadaver specimens in visualisation of anatomical structures of the ankle on proton density Magnetic Resonance Imaging (MRI) through a visual grading analysis (VGA) study

Cited by 11 publications

References 31 publications

Comparison of the histological structure of the tibial nerve and its terminal branches in the fresh and fresh-frozen cadavers

Comparison of the histological structure of the tibial nerve and its terminal branches in the fresh and fresh-frozen cadavers

Current and potential use of fresh frozen cadaver in surgical training and anatomical education

A noninvasive MRI based approach to estimate the mechanical properties of human knee ligaments

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