Influence of incidental radiation dose in the subventricular zone on survival in patients with glioblastoma multiforme treated with surgery, radiotherapy, and temozolomide

Arnalot, Palmira Foro; Pera, O.; Rodriguez, Noah; Sanz, X.; Reig, A.; Membrive, I.; Ortiz, Alejandra Giménez; Granado, Raquel; Algara, Manuel

doi:10.1007/s12094-017-1659-5

Cited by 9 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study by Foro et al (23) on 65 GBM patients was the only one to find an improvement in PFS in patients who received a cSVZ dose higher than 48.8 Gy (75 th percentile) (HR 0.46; 95% CI=0.23-0.91 P=0.028), but no association with OS.…”

Section: Studies Favoring Targeting the Svzmentioning

confidence: 94%

The Role of Subventricular Zone Irradiation in High-Grade Gliomas – a Narrative Review

Ciobanu

2023

JMRO

View full text Add to dashboard Cite

High-grade gliomas (HGGs) are aggressive brain tumours associated with poor prognosis and treatment outcomes. Novel therapeutic strategies are urgently needed to improve patient outcomes. One approach currently under investigation is targeting the subventricular zone (SVZ), a specialized region of neural stem and progenitor cells in the adult brain. This review explores the role of the SVZ in gliomagenesis and examines preclinical and clinical studies investigating the effects of SVZ irradiation in HGGs. The potential mechanisms underlying the efficacy of SVZ irradiation are discussed, and the clinical relevance of SVZ in HGGs is highlighted. Retrospective studies examining the relationship between SVZ irradiation and survival metrics have yielded mixed results, with some studies favouring targeting the SVZ and others not. Prospective studies have also shown conflicting findings. The debate over whether to irradiate or spare the SVZ continues, considering the potential impact on cognitive function and survival outcomes. This review provides insights into the current understanding of the SVZ as a potential therapeutic target in HGGs and outlines future directions for research and clinical translation.

show abstract

Section: Studies Favoring Targeting the Svzmentioning

confidence: 94%

The Role of Subventricular Zone Irradiation in High-Grade Gliomas – a Narrative Review

Ciobanu

2023

JMRO

View full text Add to dashboard Cite

show abstract

“…In 2017, Foro Arnalot et al. reported another retrospective study of 65 patients showing an improvement in PFS but not in OS if the cSVZ received a dose superior or equal to 48.8 Gy ( 130 ). Khalifa et al.…”

Section: The Subventricular Zone In Clinical Practicementioning

confidence: 99%

The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells

et al. 2021

View full text Add to dashboard Cite

Both in adult and children, high-grade gliomas (WHO grades III and IV) account for a high proportion of death due to cancer. This poor prognosis is a direct consequence of tumor recurrences occurring within few months despite a multimodal therapy consisting of a surgical resection followed by chemotherapy and radiotherapy. There is increasing evidence that glioma stem cells (GSCs) contribute to tumor recurrences. In fact, GSCs can migrate out of the tumor mass and reach the subventricular zone (SVZ), a neurogenic niche persisting after birth. Once nested in the SVZ, GSCs can escape a surgical intervention and resist to treatments. The present review will define GSCs and describe their similarities with neural stem cells, residents of the SVZ. The architectural organization of the SVZ will be described both for humans and rodents. The migratory routes taken by GSCs to reach the SVZ and the signaling pathways involved in their migration will also be described hereafter. In addition, we will debate the advantages of the microenvironment provided by the SVZ for GSCs and how this could contribute to tumor recurrences. Finally, we will discuss the clinical relevance of the SVZ in adult GBM and pediatric HGG and the therapeutic advantages of targeting that neurogenic region in both clinical situations.

show abstract

“…New therapeutic strategies include tumor-treating fields and immune checkpoint inhibitors have been explored to improve clinical outcomes in recent years [ 1 ]. However, even after aggressive treatment, both local and distant tumor recurrence are usually inevitable [ 2 ]. The rate of distant recurrence has even been reported as high as 43% [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions

Dong

Pan

et al. 2023

Stem Cell Res Ther

View full text Add to dashboard Cite

Background Glioblastoma is one of the most common and aggressive adult brain tumors. The conventional treatment strategy, surgery combined with chemoradiotherapy, did not change the fact that the recurrence rate was high and the survival rate was low. Over the years, accumulating evidence has shown that the subventricular zone has an important role in the recurrence and treatment resistance of glioblastoma. The human adult subventricular zone contains neural stem cells and glioma stem cells that are probably a part of reason for therapy resistance and recurrence of glioblastoma. Main body Over the years, both bench and bedside evidences strongly support the view that the presence of neural stem cells and glioma stem cells in the subventricular zone may be the crucial factor of recurrence of glioblastoma after conventional therapy. It emphasizes the necessity to explore new therapy strategies with the aim to target subventricular zone to eradicate neural stem cells or glioma stem cells. In this review, we summarize the recent preclinical and clinical advances in targeting neural stem cells in the subventricular zone for glioblastoma treatment, and clarify the prospects and challenges in clinical application. Conclusions Although there remain unresolved issues, current advances provide us with a lot of evidence that targeting the neural stem cells and glioma stem cells in subventricular zone may have the potential to solve the dilemma of glioblastoma recurrence and treatment resistance.

show abstract

Influence of incidental radiation dose in the subventricular zone on survival in patients with glioblastoma multiforme treated with surgery, radiotherapy, and temozolomide

Abstract: High-dose radiation in the contralateral subventricular zone was associated with a significant improvement in progression-free survival but not overall survival in patients treated for glioblastoma multiforme.

Cited by 9 publications

References 15 publications

The Role of Subventricular Zone Irradiation in High-Grade Gliomas – a Narrative Review

The Role of Subventricular Zone Irradiation in High-Grade Gliomas – a Narrative Review

The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells

Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions

Contact Info

Product

Resources

About