Late deviance detection in rats is reduced, while early deviance detection is augmented by the NMDA receptor antagonist MK-801

Harms, Lauren; Fulham, W. Ross; Todd, Juanita; Meehan, Crystal L.; Schall, Ulrich; Hodgson, Deborah M.; Michie, Patricia T.

doi:10.1016/j.schres.2017.03.042

Cited by 34 publications

(26 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the human literature [ 13 , 17 , 24 , 25 , 32 , 44 ], deviance sensitivity is tested using a condition that corresponds to our diverse-broad control. A number of rodent studies using epidural or scalp recordings reported deviance sensitivity results using control sequences matching ours [ 31 , 45 ]. Our study expands these results by showing deviance sensitivity of intracerebral, local responses.…”

Section: Discussionmentioning

confidence: 52%

Deviance sensitivity in the auditory cortex of freely moving rats

2018

View full text Add to dashboard Cite

Deviance sensitivity is the specific response to a surprising stimulus, one that violates expectations set by the past stimulation stream. In audition, deviance sensitivity is often conflated with stimulus-specific adaptation (SSA), the decrease in responses to a common stimulus that only partially generalizes to other, rare stimuli. SSA is usually measured using oddball sequences, where a common (standard) tone and a rare (deviant) tone are randomly intermixed. However, the larger responses to a tone when deviant does not necessarily represent deviance sensitivity. Deviance sensitivity is commonly tested using a control sequence in which many different tones serve as the standard, eliminating the expectations set by the standard ('deviant among many standards'). When the response to a tone when deviant (against a single standard) is larger than the responses to the same tone in the control sequence, it is concluded that true deviance sensitivity occurs. In primary auditory cortex of anesthetized rats, responses to deviants and to the same tones in the control condition are comparable in size. We recorded local field potentials and multiunit activity from the auditory cortex of awake, freely moving rats, implanted with 32-channel drivable microelectrode arrays and using telemetry. We observed highly significant SSA in the awake state. Moreover, the responses to a tone when deviant were significantly larger than the responses to the same tone in the control condition. These results establish the presence of true deviance sensitivity in primary auditory cortex in awake rats.

show abstract

Section: Discussionmentioning

confidence: 52%

Deviance sensitivity in the auditory cortex of freely moving rats

2018

View full text Add to dashboard Cite

show abstract

“…; Harms et al. ). In the preclinical setting, a pitch deviance protocol is the mostly used paradigm.…”

Section: Discussionmentioning

confidence: 98%

“…), or the standard as well as the deviant amplitude reduced, but with larger reduction of the deviant amplitude (Harms ; Harms et al. ). There is also strong evidence that the key components of MMN, stimulus‐specific adaptation and deviance detection are differentiable in mouse cortical circuits and engage different types of interneurons (Hamm and Yuste ).…”

Section: Discussionmentioning

confidence: 99%

A comprehensive analysis of auditory event-related potentials and network oscillations in an NMDA receptor antagonist mouse model using a novel wireless recording technology

et al. 2018

View full text Add to dashboard Cite

There is growing evidence that impaired sensory processing significantly contributes to cognitive deficits found in schizophrenia. Electroencephalography (EEG) has become an important preclinical and clinical technique to investigate the underlying mechanisms of neurophysiological dysfunctions in psychiatric disorders. Patients with schizophrenia show marked deficits in auditory event‐related potentials (ERP), the detection of deviant auditory stimuli (mismatch negativity, MMN), the generation and synchronization of 40 Hz gamma oscillations in response to steady‐state auditory stimulation (ASSR) and reduced auditory‐evoked oscillation in the gamma range. Due to a novel data‐logging technology (Neurologger, TSE Systems), it is now possible to record wireless EEG data in awake, free‐moving small rodents without any restrictions due to size of the device or attached cables. Recently, a new version of the Neurologger was released with improved performance to record time‐locked event‐related EEG signals. In this study, we were able to show in mice that pharmacological intervention with the NMDA receptor antagonists Ketamine and MK‐801 can impair a comprehensive selection of EEG/ERP readouts (ERP N1 amplitude, 40 Hz ASSR, basal and evoked gamma oscillation, MMN) and therefore mimic the EEG deficits observed in patients with schizophrenia. Our data support the translational value of NMDA receptor antagonists as a model for preclinical evaluation of sensory processing deficits relevant to schizophrenia. Further, the new Neurologger system is a suitable device for wireless recording of clinically relevant EEG biomarkers in freely moving mice and a robust translational tool to investigate novel therapeutic approaches regarding sensory processing deficits related to psychiatric disorders such as schizophrenia.

show abstract

“…Recent studies have focused on principal neuron populations as well as inhibitory interneurons and are beginning to yield significant insights into the mechanisms of MMN and sensory context processing (Natan et al, 2015;Duque et al, 2016;Hamm and Yuste, 2016;Musall et al, 2017). Additionally, the oddball paradigm has been used in conjunction with pharmacology (Ehrlichman et al, 2008(Ehrlichman et al, , 2009Bristow et al, 2016;Aleksandrov et al, 2018;Harms et al, 2018;Lee et al, 2018), optogenetics (Natan et al, 2015(Natan et al, , 2017, and chemogenetics (Hamm and Yuste, 2016) to isolate mechanisms responsible for the components of MMN. The genetic access along with the available manipulations that animal models afford allows significant insights to the mechanisms of MMN in human populations, both basic and clinical.…”

Section: The "Oddball" Paradigmmentioning

confidence: 99%