High doses of vitamin C plus E reduce strength training-induced improvements in areal bone mineral density in elderly men

Stunes, Astrid Kamilla; Syversen, Unni; Berntsen, Sveinung; Paulsen, Gøran; Stea, Tonje Holte; Hetlelid, Ken J.; Lohne-Seiler, Hilde; Mosti, Mats Peder; Bjørnsen, Thomas; Raastad, Truls; Haugeberg, Glenn

doi:10.1007/s00421-017-3588-y

Cited by 20 publications

(19 citation statements)

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“…On this matter, research on strength exercise models in humans is scarce and the first published investigations came up with conflicting results. While some reported a positive effect of vitamins C and E on muscle mass and plasma antioxidant status of elderly people [28,29], others showed negative effects on muscle thickness [30] and bone mineral density [31]. Regarding young people, available findings show that supplementation may actually hamper strength gain [32,33] or is ineffective [34,35].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis

Dutra

Martins

Ribeiro

et al. 2020

Journal of Sports Medicine

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Intense muscle contractile activity can result in reactive oxygen species production in humans. Thus, supplementation of antioxidant vitamins has been used to prevent oxidative stress, enhance performance, and improve muscle mass. In this sense, randomized controlled studies on the effect of vitamin C and E supplementation combined with strength training (ST) on skeletal muscle mass and strength have been conducted. As these studies have come to ambiguous findings, a better understanding of this topic has yet to emerge. The purpose of the present review is to discuss the current knowledge about the effect of vitamin C and E supplementation on muscle mass and strength gains induced by ST. Search for articles was conducted in the following databases: PubMed/Medline, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, and Google Scholar. This work is in line with the recommendations of the PRISMA statement. Eligible studies were placebo-controlled trials with a minimum of four weeks of ST combined with vitamin C and E supplementation. The quality of each included study was evaluated using the Physiotherapy Evidence Database Scale (PEDro). 134 studies were found to be potentially eligible, but only seven were selected to be included in the qualitative synthesis. A meta-analysis of muscle strength was conducted with 3 studies. Findings from these studies indicate that vitamins C and E has no effect on muscle force production after chronic ST. Most of the evidence suggests that this kind of supplementation does not potentiate muscle growth and could possibly attenuate hypertrophy over time.

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Section: Introductionmentioning

confidence: 99%

The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis

Dutra

Martins

Ribeiro

et al. 2020

Journal of Sports Medicine

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“…However, subsequent studies demonstrated that 1) aged αTTP knockout mice had reduced cortical bone mass, 2) low dietary Vitamin E intake did not increase bone mass in mature rats, 3) high dietary Vitamin E intake did not reduce cortical bone mass in mature rats, and 4) high Vitamin E intake did not affect cortical bone mass in maturing rats [5,6]. Human studies, likewise, have shown conflicting results regarding the beneficial or detrimental effects of Vitamin E on bone health [7][8][9][10][11][12][13]. Thus, the role of Vitamin E in bone remains unclear and somewhat controversial.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival

et al. 2018

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Osteocytes experience plasma membrane disruptions (PMD) that initiate mechanotransduction both in vitro and in vivo in response to mechanical loading, suggesting that osteocytes use PMD to sense and adapt to mechanical stimuli. PMD repair is crucial for cell survival; antioxidants (e.g., alpha-tocopherol, also known as Vitamin E) promote repair while reactive oxygen species (ROS), which can accumulate during exercise, inhibit repair. The goal of this study was to determine whether depleting Vitamin E in the diet would impact osteocyte survival and bone adaptation with loading. Male CD-1 mice (3 wk old) were fed either a regular diet (RD) or Vitamin E-deficient diet (VEDD) for up to 11 weeks. Mice from each dietary group either served as sedentary controls with normal cage activity, or were subjected to treadmill exercise (one bout of exercise or daily exercise for 5 weeks). VEDD-fed mice showed more PMD-affected osteocytes (+50%) after a single exercise bout suggesting impaired PMD repair following Vitamin E deprivation. After 5 weeks of daily exercise, VEDD mice failed to show an exercise-induced increase in osteocyte PMD formation, and showed signs of increased osteocytic oxidative stress and impaired osteocyte survival. Surprisingly, exercise-induced increases in cortical bone formation rate were only significant for VEDD-fed mice. This result may be consistent with previous studies in skeletal muscle, where myocyte PMD repair failure (e.g., with muscular dystrophy) initially triggers hypertrophy but later leads to widespread degeneration. In vitro, mechanically wounded MLO-Y4 cells displayed increased post-wounding necrosis (+40 fold) in the presence of H 2 O 2 , which could be prevented by Vitamin E pre-treatment. Taken together, our data support the idea that antioxidant-influenced osteocyte membrane repair is a vital aspect of bone mechanosensation in the osteocytic control of PMD-driven bone adaptation.

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“…However, the study was carried out for a short time (12 weeks) and in a small group of volunteers, and neither smoking status nor primary VC serum levels were considered. In a similarly projected study [86] with a longer, six-month follow-up, no similar restrictive effect of antioxidant supplementation to benefit from systematic resistance training was seen. No difference was observed between the groups with antioxidant supplementation, systematic physical activity and the connection of both interventions.…”

Section: Interventional Studiesmentioning

confidence: 89%

“…In the other presented clinical trials only laboratory markers of bone metabolism were taken into consideration. The first of them was the study with a design similar to Stunes [86] and Chuin [88] in which the strength training program was one of the tested interventions. The Maïmoun team [68] pilot study recruited nine elderly women and four men to an 8-week experiment with VC (500 mg) and VE (100 mg) supplementation connected with supervised, one-hour training three times a week.…”

Section: Interventional Studiesmentioning

confidence: 99%

Role of Vitamin C in Osteoporosis Development and Treatment—A Literature Review

et al. 2020

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Osteoporosis and associated low energy fractures are a significant clinical problem, especially in the elderly population. The occurrence of a hip fracture is associated with significant mortality and a high risk of disability. For this, apart from the treatment of osteoporosis, effective prevention of both the development of the disease and related fractures is extremely important. One aspect of osteoporosis prevention is proper dietary calcium intake and normal vitamin D3 levels. However, there is some evidence for a potential role of vitamin C in osteoporosis and fracture prevention, too. This review aims to summarize the current knowledge about the role of vitamin C in osteoporosis development, prevention and treatment. The PubMed/Medline search on the role of vitamin C in bone metabolism database was performed for articles between 2000 and May 2020. Reports from in vitro and animal studies seem promising. Epidemiological studies also indicate the positive effect of high vitamin C content in the daily diet on bone mineral density. Despite promising observations, there are still few observational and intervention studies and their results do not allow for unequivocal determination of the benefits of high daily intake of vitamin C or its long-term supplementation.

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High doses of vitamin C plus E reduce strength training-induced improvements in areal bone mineral density in elderly men

Abstract: High doses of antioxidant supplementations may constrain the favorable skeletal benefits of 12 weeks of resistance exercise in healthy elderly men.

Cited by 20 publications

References 47 publications

The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis

The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis

Inhibition of Osteocyte Membrane Repair Activity via Dietary Vitamin E Deprivation Impairs Osteocyte Survival

Role of Vitamin C in Osteoporosis Development and Treatment—A Literature Review

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