Varicella-Zoster Virus Gastritis: Case Report and Review of the Literature

Nohr, Erik; Itani, Doha; Andrews, Christopher N.; Kelly, Margaret M.

doi:10.1177/1066896917696751

Cited by 40 publications

(5 citation statements)

References 13 publications

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“…In contrast to several studies reporting prevalence rates of H. pylori in patients with end-stage liver disease of 50% pretransplant and 5.6% posttransplant [16][17][18][19], we had a zero H. pylori infection rate in our post-LTx patients, likely because of testing and eradication of H. pylori prior to LTx in our patient population.…”

Section: Discussioncontrasting

confidence: 64%

“…In all 12 cases of nausea/anorexia, biopsies were obtained from the stomach or small bowel for pathological examination, but none were positive for H. pylori or viral inclusions. Although we did not see any viral gastritis cases, Nohr et al reported a case of Varicella-zoster virus gastritis post-LTx, who also had skin manifestations and systemic involvement, and was successfully treated by antiviral agents [18].…”

Section: Discussioncontrasting

confidence: 62%

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The Utilization and Diagnostic Yield of Upper Endoscopy for Evaluation of Gastrointestinal Symptoms Within the First Year After Liver Transplantation

Daglilar

Connolly

Tahan

et al. 2020

Cureus

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BackgroundGastrointestinal (GI) symptoms impact quality of life and increase health care utilization after liver transplantation (LTx). Esophagogastroduodenoscopy (EGD) is commonly used to investigate these symptoms. AimsThe aim of this study was to investigate the diagnostic yield and utilization of EGD after LTx for common GI symptoms. MethodsThis single-center retrospective cohort study was conducted at a large liver transplant center and included all adults who underwent EGD within the first year after receiving LTx between January 1, 2015, and December 31, 2016. Biliary procedures were excluded. ResultsOf 437 patients who underwent LTx during the study period, 64 (15%) underwent EGD for the evaluation of GI symptoms within the first year of transplantation. After applying exclusion criteria, 57 (13%) cases were analyzed. GI hemorrhage (hematemesis/melena) was the most common reason (4%; n=18) for evaluation with EGD followed by nausea/anorexia (3%; n=12). Symptoms were investigated with EGD, including epigastric/abdominal pain (2%; n=9), dysphagia/odynophagia (2%; n=8), anemia (1%; n=5), diarrhea (1%; n=4), and heartburn (0.2%; n=1). The diagnostic yield of EGD was highest with GI hemorrhage (83%) followed by dysphagia/odynophagia (75%). EGD diagnostic yield was lower for the other symptoms, ranging from 0% to 25%. ConclusionsEGD was commonly utilized within the first year of LTx, with the highest diagnostic yields for GI hemorrhage and dysphagia/odynophagia. Because of the low diagnostic yield of EGD for other symptoms, we recommend a careful selection of patients for EGD following LTx.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussioncontrasting

confidence: 62%

The Utilization and Diagnostic Yield of Upper Endoscopy for Evaluation of Gastrointestinal Symptoms Within the First Year After Liver Transplantation

Daglilar

Connolly

Tahan

et al. 2020

Cureus

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“…2 The involvement of gastrointestinal tract by VZV has also been documented, with stomach as a common site. 4 Perianal shingles has been further described. 5,6 Other rare sites of involvement include lungs, brain, cerebellum, spinal cord, and retina.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Varicella Zoster Infection in Hemorrhoids in a Patient With Inflammatory Bowel Disease

Siatecka,

Al-Awami,

Siddiqi

et al. 2024

The American Journal of Dermatopathology

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Hemorrhoids are normal anatomical structures in the anus. When symptomatic, they prompt medical attention due to pain, rectal bleeding, and discomfort. Treatment includes dietary modifications, rubber band ligations, sclerotherapy, cryotherapy, or hemorrhoidectomy. Histologic examination is important to rule out incidental findings, such as perianal intraepithelial neoplasia, anal carcinoma, melanoma, or coexisting infections. Special attention should be given when patient is immunocompromised. We present a case of a 41-year-old man with a history of ulcerative colitis on adalimumab who presented with anal lesions. He was diagnosed with hemorrhoids and surgically treated. Microscopic examination confirmed the diagnosis of hemorrhoids. However, foci of epithelium with viral cytopathic effects were noted. A varicella zoster virus (VZV)-specific immunostain was positive in the areas of interest confirming the diagnosis of the VZV infection limited to the hemorrhoids. Combined herpes simplex virus type 1 and 2 (HSV 1 and HSV 2) immunostain was also performed and was negative. Anal herpes has been widely described in the literature, particularly in immunocompromised patients. However, isolated VZV infection in hemorrhoids to the best of our knowledge has never been reported.

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“…In digestive system, VZV infection may lead to gastritis [10], acute pancreatitis [11], or acute liver failure (ALF) [12]. VZV infection also play a role in severe autoimmune hepatitis because of immune cross reaction and autoimmune disorder [13] [14].…”

Section: Discussionmentioning

confidence: 99%

Virus-associated hemophagocytic syndrome caused by influ B and varicella-zoster virus co-infection

Chen,

Wang,

Yan

2024

Preprint

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Background:Varicella (chicken pox), which caused by the varicella-zoster virus(VZV), is usually self-limiting and benign. However, VZV can lead to significant and serious complications, especially in immunocompromised patients or accompanied by other pathogens infection. HPS caused by varicella-zoster and influ B virus co-infection is rare. Case presentation:A 15-years-old boy was admitted to our hospital because of general rash, severe back and low back pain. CT scan revealed pneumonia in left upper lobe. Initial blood tests showed normal blood WBC and PLT, mild liver dysfunction, enhanced D-dimer and myocardial enzyme. However, after 4-days treatment of acyclovir, antibiotics, and analgesic therapy, his pain did not relieved and fever developed. At the same time, hyperferritinemia, abrupt reduction on blood WBC and PLT count were observed. Virus-associated hemophagocytic syndrome (VHAS)was confirmed.Then, intravenous drip dexamethasone(10mg/day) and gamma globulin(10mg/day) were administrated. He recovered completely at last. Conclusions:Disseminated Varicella which was accompanied by influenza B virus and bacteria infection is infrequent. Disseminated varicella may cause significant morbidity and even mortality in immunocompromised patients. Hemophilic syndrome induced by duel-virus and bacteria infection is limited and usually fetal.Anti-bacterial therapy, early identification of haemophilus syndrome and timely administration of glucocorticoids and gamma globulin are the key links of treatments.

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Varicella-Zoster Virus Gastritis: Case Report and Review of the Literature

Cited by 40 publications

References 13 publications

The Utilization and Diagnostic Yield of Upper Endoscopy for Evaluation of Gastrointestinal Symptoms Within the First Year After Liver Transplantation

The Utilization and Diagnostic Yield of Upper Endoscopy for Evaluation of Gastrointestinal Symptoms Within the First Year After Liver Transplantation

A Rare Case of Varicella Zoster Infection in Hemorrhoids in a Patient With Inflammatory Bowel Disease

Virus-associated hemophagocytic syndrome caused by influ B and varicella-zoster virus co-infection

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