Medically Graded Honey Supplementation Formula to Preterm Infants as a Prebiotic

Aly, Hany; Said, Reem N.; Wali, Iman E.; Elwakkad, Amany; Soliman, Yssra; Awad, Alaa; Shawky, M Ahmed; Alam, Mohamed S. Abu; Mohamed, Mohamed A.

doi:10.1097/mpg.0000000000001597

Cited by 21 publications

(18 citation statements)

References 18 publications

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“…In another study, certain genera of the maternal microbiota and maternal SDI were positively correlated with neonatal male head circumference ( 65 ). In newborn preterm infants, receiving an intervention of 10 to 15 g of medically graded bee honey (a source of oligosaccharides) daily was associated with increased head circumference after 2 weeks, in addition to increased colonization with Bifidobacterium bifidum compared to control receiving no intervention ( 66 ). However, to our knowledge, head circumference has not been examined in concert with other nutritional metrics in relation to the gut microbiota diversity or composition in older infants and children.…”

Section: Discussionmentioning

confidence: 99%

Nutrition and the Gut Microbiota in 10- to 18-Month-Old Children Living in Urban Slums of Mumbai, India

Huey

Jiang

Fedarko

et al. 2020

mSphere

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In this cross-sectional study, we describe the composition and diversity of the gut microbiota among undernourished children living in urban slums of Mumbai, India, and determine how nutritional status, including anthropometric measurements, dietary intakes from complementary foods, feeding practices, and micronutrient concentrations, is associated with their gut microbiota. We collected rectal swabs from children aged 10 to 18 months living in urban slums of Mumbai participating in a randomized controlled feeding trial and conducted 16S rRNA sequencing to determine the composition of the gut microbiota. Across the study cohort, Proteobacteria dominated the gut microbiota at over 80% relative abundance, with Actinobacteria representation at <4%, suggesting immaturity of the gut. Increased microbial α-diversity was associated with current breastfeeding, greater head circumference, higher fat intake, and lower hemoglobin concentration and weight-for-length Z-score. In redundancy analyses, 47% of the variation in Faith’s phylogenetic diversity (Faith’s PD) could be accounted for by age and by iron and polyunsaturated fatty acid intakes. Differences in community structure (β-diversity) of the microbiota were observed among those consuming fats and oils the previous day compared to those not consuming fats and oils the previous day. Our findings suggest that growth, diet, and feeding practices are associated with gut microbiota metrics in undernourished children, whose gut microbiota were comprised mainly of Proteobacteria, a phylum containing many potentially pathogenic taxa. IMPORTANCE The impact of comprehensive nutritional status, defined as growth, nutritional blood biomarkers, dietary intakes, and feeding practices, on the gut microbiome in children living in low-resource settings has remained underreported in microbiome research. Among undernourished children living in urban slums of Mumbai, India, we observed a high relative abundance of Proteobacteria, a phylum including many potentially pathogenic species similar to the composition in preterm infants, suggesting immaturity of the gut, or potentially a high inflammatory burden. We found head circumference, fat and iron intake, and current breastfeeding were positively associated with microbial diversity, while hemoglobin and weight for length were associated with lower diversity. Findings suggest that examining comprehensive nutrition is critical to gain more understanding of how nutrition and the gut microbiota are linked, particularly in vulnerable populations such as children in urban slum settings.

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Section: Discussionmentioning

confidence: 99%

Nutrition and the Gut Microbiota in 10- to 18-Month-Old Children Living in Urban Slums of Mumbai, India

Huey

Jiang

Fedarko

et al. 2020

mSphere

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“…One study evaluated the effect of different concentration of bee honey [64]. Compared to control with no honey, other intervention groups (5 g, 10 g, and 15 g honey) demonstrated weight gain by the second week.…”

Section: Other Interventionsmentioning

confidence: 99%

Feeding Interventions for Infants with Growth Failure in the First Six Months of Life: A Systematic Review

Rana

McGrath²,

Gupta

et al. 2020

Nutrients

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(1) Introduction: Current evidence on managing infants under six months with growth failure or other nutrition-related risk is sparse and low quality. This review aims to inform research priorities to fill this evidence gap, focusing on breastfeeding practices. (2) Methods: We searched PubMed, CINAHL Plus, and Cochrane Library for studies on feeding interventions that aim to restore or improve the volume or quality of breastmilk and breastfeeding when breastfeeding practices are sub-optimal or prematurely stopped. We included studies from both low- and middle-income countries and high-income countries. (3) Results: Forty-seven studies met the inclusion criteria. Most were from high-income countries (n = 35, 74.5%) and included infants who were at risk of growth failure at birth (preterm infants/small for gestational age) and newborns with early growth faltering. Interventions included formula fortification or supplementation (n = 31, 66%), enteral feeds (n = 8, 17%), cup feeding (n = 2, 4.2%), and other (n = 6, 12.8%). Outcomes included anthropometric change (n = 40, 85.1%), reported feeding practices (n = 16, 34%), morbidity (n = 11, 23.4%), and mortality (n = 5, 10.6%). Of 31 studies that assessed formula fortification or supplementation, 30 reported anthropometric changes (n = 17 no effect, n = 9 positive, n = 4 mixed), seven morbidity (n = 3 no effect, n = 2 positive, n = 2 negative), five feeding (n = 2 positive, n = 2 no effect, n = 1 negative), and four mortality (n = 3 no effect, n = 1 negative). Of eight studies that assessed enteral feed interventions, seven reported anthropometric changes (n = 4 positive, n = 3 no effect), five feeding practices (n = 2 positive, n = 2 no effect, n = 1 negative), four morbidity (n = 4 no effect), and one reported mortality (n = 1 no effect). Overall, interventions with positive effects on feeding practices were cup feeding compared to bottle-feeding among preterm; nasogastric tube feed compared to bottle-feeding among low birth weight preterm; and early progressive feeding compared to delayed feeding among extremely low birth weight preterm. Bovine/cow milk feeding and high volume feeding interventions had an unfavourable effect, while electric breast pump and Galactagogue had a mixed effect. Regarding anthropometric outcomes, overall, macronutrient fortified formula, cream supplementation, and fortified human milk formula had a positive effect (weight gain) on preterm infants. Interventions comparing human breastmilk/donor milk with formula had mixed effects. Overall, only human milk compared to formula intervention had a positive effect on morbidity among preterm infants, while none of the interventions had any positive effect on mortality. Bovine/cow milk supplementation had unfavourable effects on both morbidity and mortality. (4) Conclusion: Future research should prioritise low- and middle-income countries, include infants presenting with growth failure in the post-neonatal period and record effects on morbidity and mortality outcomes.

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“…Traditional culture-based techniques [17][18][19][20][21], 16S rRNA short amplicon sequencing [3, 5-7, 13, 22-65], Shotgun metagenomics [2], Temperature gradient gel electrophoresis (TGGE) [9,10,[66][67][68][69][70][71][72], Denaturing gradient gel electrophoresis (DGGE) [8,[73][74][75][76], HITChip [77,78], Fluorescent In-Situ Hybridisation Analysis (FISH) [79,80], Terminal restriction fragment length polymorphism (TRFLP) [81][82][83], Quantitative PCR (qPCR) [9,44,[84][85][86][87][88][89][90][91][92][93], Long-read nanopore sequencing [94], and…”

Section: Primary Techniquesmentioning

confidence: 99%

Methods for exploring the faecal microbiome of premature infants: a review

Westaway

Huerlimann

Miller

et al. 2021

matern health, neonatol and perinatol

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The premature infant gut microbiome plays an important part in infant health and development, and recognition of the implications of microbial dysbiosis in premature infants has prompted significant research into these issues. The approaches to designing investigations into microbial populations are many and varied, each with its own benefits and limitations. The technique used can influence results, contributing to heterogeneity across studies. This review aimed to describe the most common techniques used in researching the preterm infant microbiome, detailing their various limitations. The objective was to provide those entering the field with a broad understanding of available methodologies, so that the likely effects of their use can be factored into literature interpretation and future study design. We found that although many techniques are used for characterising the premature infant microbiome, 16S rRNA short amplicon sequencing is the most common. 16S rRNA short amplicon sequencing has several benefits, including high accuracy, discoverability and high throughput capacity. However, this technique has limitations. Each stage of the protocol offers opportunities for the injection of bias. Bias can contribute to variability between studies using 16S rRNA high throughout sequencing. Thus, we recommend that the interpretation of previous results and future study design be given careful consideration.

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Medically Graded Honey Supplementation Formula to Preterm Infants as a Prebiotic

Abstract: Supplementation of milk formula with medically graded honey was associated with changes in physical growth and colonic microbiota of preterm infants. Further studies are needed to examine the sustainability of these effects and associated long-term outcomes.

Cited by 21 publications

References 18 publications

Nutrition and the Gut Microbiota in 10- to 18-Month-Old Children Living in Urban Slums of Mumbai, India

Nutrition and the Gut Microbiota in 10- to 18-Month-Old Children Living in Urban Slums of Mumbai, India

Feeding Interventions for Infants with Growth Failure in the First Six Months of Life: A Systematic Review

Methods for exploring the faecal microbiome of premature infants: a review

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