“…Here, we offer the first direct testing of this hypothesis by examining behavioral, neurophysiological, gray matter volume, and functional connectivity signatures of interoception in healthy subjects and HTD patients without neurocognitive alterations (featuring no cognitive deficits, gray matter abnormalities, or white matter alterations). In particular, our multidimensional approach comprised analyses of (a) behavioral performance on a validated HBD task (Canales‐Johnson et al, ; Couto et al, ; Yoris et al, ); (b) ongoing modulations of the HEP, an electrophysiological cortical signature modulated by attention to cardiac signals (García‐Cordero et al, ; Yoris et al, ; Terhaar et al, ); and (c) neuroimaging recordings, to evaluate anatomical and functional connectivity properties of key interoceptive regions, namely: the insula, the anterior cingulate cortex (ACC), and the somatosensory cortex (Adolfi et al, ; Craig, ; Critchley, Wiens, Rotshtein, Ohman, & Dolan, ; Fukushima, Terasawa, & Umeda, ; Hassanpour et al, ). In light of the above considerations, we predicted that HTD patients would exhibit behavioral interoceptive deficits and alterations in key neural correlates of such a domain.…”