Value of procalcitonin as a biomarker for postoperative hospital-acquired pneumonia after abdominal surgery

Elyazed, Mohamed M. Abu; Zaki, Maysaa El Sayed

doi:10.4097/kjae.2017.70.2.177

Cited by 7 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(Independent samples T-test). Abu Elyazed and El Sayed Zakiin in their study found the diagnostic accuracy of PCT for diagnosing post-operative hospitalacquired pneumonia on day 2 with mean level 1.52 ng/mL [10]. Peritonitis and pneumonitis were the major causes of sepsis in our study population.…”

Section: Dutta Et Almentioning

confidence: 50%

Intra-Abdominal Hypertension and Increased Serum Procalcitonin Levels Are Important Prognostic Markers in Critically Ill Surgical Patient’s Outcome: A Prospective Observational Study

Dutta,

Prasad,

Faisal

et al. 2023

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The objective of the study is to determine the clinical value of procalcitonin (PCT) levels and in recognizing surgical complications, morbidity and mortality in a heterogeneous group of general surgical patient population admitted in casualty ward and intensive care unit (ICU). Methods: A prospective, observational study was conducted on 100 patients by purposive sampling for blood and ascites in the peritoneal cavity, bowel distension and edema, high-volume resuscitation and massive transfusion, damage control surgery in traumatic patients, excessive tension after abdominal closure, post-operative ileus, circumferential abdominal eschar in burn patients, and hemodilution with severe sepsis were enrolled within 24 h of admission to the ICU or casualty ward in the Department of General Surgery, J.L.N. Medical College and Hospital, Ajmer, from August 2021 to December 2022. Results: The mean age of the overall patient population for the study is 52.29 years and it ranges between 16 years and 84 years. 79% of the patients presented with intra-abdominal hypertension (IAH), and mean serum PCT level in the IAH group is 4.47±7.49 which is higher than that in the non- IAH group (p<0.05). The mean serum PCT levels among the group having peritonitis as the cause of sepsis is 5.69 ng/mL and having pneumonitis as the cause of sepsis is 6.74 ng/mL (p=0.033). Conclusion: Serum PCT, a new serum biomarker for infection and inflammation, that has been found to be more sensitive and specific for the same, is also an indicator for patient mortality and morbidity, and also correlates with patient’s length of hospital stay can be said to have an important role in prediction of critically ill surgical patient’s outcome.

show abstract

Section: Dutta Et Almentioning

confidence: 50%

Intra-Abdominal Hypertension and Increased Serum Procalcitonin Levels Are Important Prognostic Markers in Critically Ill Surgical Patient’s Outcome: A Prospective Observational Study

Dutta,

Prasad,

Faisal

et al. 2023

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…PCT was elevated at 2nd, 3rd and 5th POD in nearly 84 % of patients with pneumonia. 26 C O N T E N T…”

Section: Discussionmentioning

confidence: 99%

Procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis

Jugoslav¹,

Jovan²,

Zoran³

et al. 2022

Scripta Medica

View full text Add to dashboard Cite

Background/Aim: Dehiscence of the colorectal anastomosis is one of the most serious complications in digestive surgery that is still present in a large percentage today, which significantly increases the cost of treatment and can lead to death. Due to all the above, early detection of anastomotic dehiscence is very important, as well as the decision on surgical treatment. Procalcitonin (PCT) is thought to be an important marker of inflammation and sepsis. Aim of this paper was to confirm PCT as a marker of great sensitivity in early diagnosis of anastomotic leakage. Methods: The study included patients who underwent surgery for colorectal cancer in the period from 2016 to 2020. Patients were operated according to an elective protocol and with an open surgical approach. In patients, PCT values were measured on the 2nd and 4th postoperative day (POD) to determine the association between elevated PCT values and the onset of dehiscence of the colorectal anastomosis. Results: A study was conducted in 118 patients in whom a stapler colorectal anastomosis was created. Colorectal anastomosis dehiscence occurred in 10 patients. In 4 patients with dehiscence, no re-surgical intervention was required, but they were taken care of by conservative methods. Repeated surgery was performed in 6 patients. In all patients with dehiscence, there was a multiple increase in the value of PCT above normal. Conclusion: PCT has high sensitivity and specificity (85 and 74 % respectively) as a marker in dehiscence of colorectal anastomosis. In this study it was found that PCT values were significantly correlated with the dehiscence of anastomo-sis 2nd POD and especially 4th POD.

show abstract

“… 18 , 19 In a retrospective study by Zhang et al, 20 infection markers were evaluated in terms of perioperative pneumonia, urinary infections, and superficial surgical site infections in 500 patients who underwent hip and knee arthroplasty and it has been reported that PCT has a high sensitivity (96%) and specificity (100%) in the diagnosis of bacterial infection. In the study conducted by Abu Elyazed et al, 21 PCT and CRP were compared in the early diagnosis of hospital-acquired pneumonia after abdominal surgery; PCT was determined to have higher sensitivity and specificity on postoperative day 2 compared to CRP levels (84% and 72% vs 70% and 60%, respectively). Nie et al 22 also argued that PCT is superior to CRP in the early diagnosis of postoperative infectious complications in traumatic spinal cord injuries and had a significant role in establishing an effective antibiotic treatment regimen in the postoperative period.…”

Section: Discussionmentioning

confidence: 99%

Serum Procalcitonin Levels in Postoperative Monitoring of Diabetic Patients with Posterior Lumber Vertebral Stabilization Surgery: A Prospective Comparative Study

Tor

Ural

2022

Turk J Anaesthesiol Reanim

View full text Add to dashboard Cite

Objective: To compare the serum procalcitonin levels and other infection markers released in response to the inflammatory response that develops secondary to the operation in patients with or without type 2 diabetes mellitus who underwent spinal instrumentation. Methods: Fifty patients, who belonged to the American Society of Anesthesiologist I-II, were between 18 and 65 years of age, and who had planned for posterior spinal instrumentation surgery were grouped into 2 as group I (n = 25) type 2 diabetic patients (group DM) and group II (n = 25) non-diabetic patients (group non-DM). On the operation day, preoperatively ( T 0 ), 5 minutes after intraoperative instrument placement (T 1 ), on postoperative 24th hour (T 2 ), 48th hour (T 3 ), 3rd day (T 4 ), 5th day (T 5 ), 7th day (T 6 ), 10th day (T 7 ), and 15th day (T 8 ), serum samples were obtained from the patients for the evaluation of procalcitonin, C-reactive protein, erythrocyte sedimentation rate, and neutrophil values. Results: Procalcitonin levels were higher in the diabetic patient group at all time points ( P < .01); C-reactive protein levels were higher in T 1 , T 2 , and T 5 in the diabetic patient group ( P < .05). There was no difference in erythrocyte sedimentation rate or neutrophil counts between the groups ( P > .05). When the alterations in procalcitonin levels were compared between diabetic and non-diabetic groups, in diabetic patients, there were significantly higher increases in the first 6 timelines ( P < .05). Conclusion: In diabetic patients, the procalcitonin levels were significantly higher at all time points, predicting an augmented bacterial infection in those patients compared with the non-diabetic patients.

show abstract

Value of procalcitonin as a biomarker for postoperative hospital-acquired pneumonia after abdominal surgery

Cited by 7 publications

References 29 publications

Intra-Abdominal Hypertension and Increased Serum Procalcitonin Levels Are Important Prognostic Markers in Critically Ill Surgical Patient’s Outcome: A Prospective Observational Study

Intra-Abdominal Hypertension and Increased Serum Procalcitonin Levels Are Important Prognostic Markers in Critically Ill Surgical Patient’s Outcome: A Prospective Observational Study

Procalcitonin is one of the predictive factors of dehiscence of the colorectal anastomosis

Serum Procalcitonin Levels in Postoperative Monitoring of Diabetic Patients with Posterior Lumber Vertebral Stabilization Surgery: A Prospective Comparative Study

Contact Info

Product

Resources

About