“…A way to enhance the absorption after the oral administration as well as, targeted biological efficacy is to produce technological delivery systems able to improve dissolution and permeation rate of the active ingredient [ 2 , 3 ]. Numerous delivery systems had been developed and studied extensively in oral drug delivery [ 4 , 5 , 6 ], but the application of this research area to nutraceuticals only is emerging very recently [ 7 , 8 , 9 , 10 , 11 , 12 ]. The milk thistle ( Silybum marianum (L.) Gaertn, Asteraceae), extract is an essential source of silymarin; it is a well-known complex of flavonolignans (silybin A and B, isosilybin A and B, silydianin, and silychristin) and flavonoids (taxifolin and quercetin) used to treat a variety of ailments like liver (hepatitis, cirrhosis, and icterus), kidney, and gallbladder problems [ 13 , 14 ].…”