Utility of Sonoclot in Prediction of Postoperative Bleeding in Pediatric Patients Undergoing Cardiac Surgery for Congenital Cyanotic Heart Disease: A Prospective Observational Study

Rajkumar, Vishwakarma; Kumar, Bhupesh; Dutta, Vikas; Mishra, Anand Kumar; Puri, Goverdhan Dutt

doi:10.1053/j.jvca.2017.02.002

Cited by 13 publications

(7 citation statements)

References 27 publications

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“…However, the value of these traditional parameters, such as PT and APTT, has been questioned in the acute perioperative setting because of the delay between blood sampling and obtaining the results. Additionally, these tests are carried out on plasma rather than whole blood, and they do not provide much information about platelet function [28] . Currently, TEG is widely used in major operations, such as heart surgery and adult liver transplant, because it contains many parameters for accurately monitoring the coagulation system.…”

Section: Discussionmentioning

confidence: 99%

Effect of Perioperative Coagulation Monitoring by Sonoclot on Short-Term Thrombosis in Pediatric Liver Transplantation

Sun¹,

Zhu²,

Liu³

et al. 2020

Preprint

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Background Sonoclot devices are used to monitor coagulation function in transplant patients. However, the appropriate value of Sonoclot parameters for reducing postoperative thrombosis in pediatric liver transplantation is not clear. Therefore, the aim of the study was to investigate the effect of coagulation monitoring by Sonoclot devices on early postoperative thrombosis after liver transplantation in children. Method The clinical data of 200 children with elective liver transplantation were collected. The effects of coagulation function monitoring by Sonoclot devices 1 h after ischemia-reperfusion on early thrombosis were analyzed. Receiver operating characteristic (ROC) analysis was used to obtain the sensitivity and cutoff value of Sonoclot parameters for the diagnosis of thrombosis. Results A total of 38 (19%) patients had thrombosis complications. 23 cases (11.5%) had postoperative hepatic artery thrombosis and 15 cases (7.5%) had portal vein and hepatic vein thrombosis. Sonoclot coagulation parameters included the following: for the thrombosis group & non-thrombosis group, whole blood activated clotting time (ACT): 178.5 ± 33.2 & 280.4 ± 58.6 (p < 0.05), clotting rate (CR): 12.4 ± 5.4 & 11.5 ± 5.7 (p > 0.05), and platelet function (PF): 3.0±1.4 & 2.6±1.1 (p>0.05). Univariate and multivariate analyses showed that ACT was an independent risk factor for postoperative thrombosis. ROC analysis found that the sensitivity of ACT for the diagnosis of postoperative thrombosis was 94.7%, and the ACT cutoff value to predict early postoperative thrombosis was 228.5 s. Conclusion ACT after ischemia-reperfusion was a risk factor for early postoperative thrombosis. It is recommended that ACT be maintained above 228.5 s to reduce postoperative thrombosis.Trial registrationApproval was obtained from the Ethics Committee of Tianjin First Center Hospital in China (Approval Number: 2016N0039KY), and written informed consent was obtained from eligible guardians. This study has been registered in clinical trial (ClinicalTrials.gov ID: ChiCTR1900026125). All processes were ethical.

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Section: Discussionmentioning

confidence: 99%

Effect of Perioperative Coagulation Monitoring by Sonoclot on Short-Term Thrombosis in Pediatric Liver Transplantation

Sun¹,

Zhu²,

Liu³

et al. 2020

Preprint

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“…Rajkumar and colleagues in India used Sonoclot point of care testing in a prospective study of postoperative bleeding in 87 children with cyanotic CHD undergoing cardiac surgery. 44 They found that of the 33.9% of children who had excessive postoperative chest tube drainage, Sonoclot glass bead activation time, clot rate, and platelet function had the highest predictive value. Children with cyanotic CHD typically have elevated hematocrits but their platelet counts may be variable.…”

Section: Bleeding and Thrombosismentioning

confidence: 98%

Noteworthy Literature published in 2017 for Congenital Cardiac Anesthesiologists

Ing

Twite

2018

Semin Cardiothorac Vasc Anesth

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“…and Dominique et al. found that postoperative bleeding can be predicted by using Sonoclot® in pediatric cardiac surgery [ 11 , 12 ]. However, we anesthesiologists would expect to predict the amount of blood loss during surgery.…”

Section: Introductionmentioning

confidence: 99%

Sonoclot® predicts operation time and blood loss after cardiopulmonary bypass in children

Saito¹,

Kawana²,

Saito³

et al. 2022

Heliyon

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Utility of Sonoclot in Prediction of Postoperative Bleeding in Pediatric Patients Undergoing Cardiac Surgery for Congenital Cyanotic Heart Disease: A Prospective Observational Study

Cited by 13 publications

References 27 publications

Effect of Perioperative Coagulation Monitoring by Sonoclot on Short-Term Thrombosis in Pediatric Liver Transplantation

Effect of Perioperative Coagulation Monitoring by Sonoclot on Short-Term Thrombosis in Pediatric Liver Transplantation

Noteworthy Literature published in 2017 for Congenital Cardiac Anesthesiologists

Sonoclot® predicts operation time and blood loss after cardiopulmonary bypass in children

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