Association of GSTO1 and GSTO2 Polymorphism with Risk of End-Stage Renal Disease Development and Patient Survival

Cimbaljevic, Slavica; Šuvakov, Sonja; Matić, Marija; Plješa-Ercegovac, Marija; Pekmezović, Tatjana; Radić, Tanja; Ćorić, Vesna; Damjanović, Tatjana; Dimković, Nada; Marković, Rodoljub; Savić-Radojević, Ana; Simić, Tatjana

doi:10.1515/jomb-2016-0009

Cited by 8 publications

(5 citation statements)

References 43 publications

(50 reference statements)

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“…Among the most common causes of CKD and progression to ESRD are diabetes mellitus (DM) (33% of adult CKD cases) and arterial hypertension (HTA) (21% of adult CKD cases) ( 9 , 10 ). The reason is a constant rise in the number of these patients which is »a medical catastrophe of world-wide dimensions« (11) .…”

Section: Introductionmentioning

confidence: 99%

Screening for Chronic Kidney Disease in Adult Males in Vojvodina: A Cross-Sectional Study

Čabarkapa¹,

Ilinčić²,

Đerić³

et al. 2017

Journal of Medical Biochemistry

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SummaryBackgroundChronic kidney disease (CKD) is one of the most significant global health problems accompanied by numerous complicatons, with constant increase in the number of affected people. This number is much higher in early phases of disease and patients are mostly asymptomatic, so early detection of CKD is crucial. The aim was examination of the prevalence of CKD in the general population of males in Vojvodina, based on estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR), and exploring the determinants and awareness of CKD.MethodsThis cross-sectional study included 3060 male examinees from the general population, over 18 years of age, whose eGFR and ACR were calculated, first morning urine specimen examined, arterial blood pressure measured and body mass index calculated. Standard biochemistry methods determined creatinine, urea, uric acid and glucose serum concentrations as well as albumin and creatinine urine levels.ResultsPrevalence of CKD in the adult male population is 7.9%, highest in men over 65 years of age (46.7%), while in the other age groups it is 3.6–12.6%. The largest number of examinees with a positive CKD marker suffer from arterial hypertension (HTA) and diabetes mellitus (DM). Only 1.3% of examinees with eGFR<60 ml/min/1.73 m2 and/or ACR≥ 3 mg/mmol had been aware of positive CKD biomarkers.ConclusionsObtained results show the prevalence of CKD in adult males is 7.9%, HTA and DM are the most important CKD risk factors and the level of CKD awareness is extremely low (1.3%) indicating the necessity for introduction of early stage disease recognition measures, including raising CKD awareness.

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Section: Introductionmentioning

confidence: 99%

Screening for Chronic Kidney Disease in Adult Males in Vojvodina: A Cross-Sectional Study

Čabarkapa¹,

Ilinčić²,

Đerić³

et al. 2017

Journal of Medical Biochemistry

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“…Only a few studies have investigated GSTO2 polymorphisms in non-malignant diseases. Cimbaljevic et al reported that individuals with the variant GSTO2 *GG genotype were at higher risk of ESRD development compared to carriers of the GSTO2 *AA genotype [ 49 ]. In our study, we found that individuals with the GSTO2 *AG genotype were more prone to symptomatic diabetic nephropathy development in comparison to the carriers of the wild-type GSTO2 *AA genotype.…”

Section: Discussionmentioning

confidence: 99%

The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk

et al. 2023

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Background and Objectives: In the development of type 2 diabetes mellitus (T2DM) and its complications, genetic and environmental factors play important roles. Diabetic nephropathy (DN), one of the major microangiopathic chronic diabetic complications, is associated with an increased risk of major cardiovascular events and all-cause mortality. The present study was designed to investigate the possible modifying effect of glutathione transferase polymorphisms (GSTM1, GSTT1, GSTP1 rs1138272/rs1695, GSTO1 rs4925 and GSTO2 rs156697) in the susceptibility to T2DM and diabetic nephropathy. Materials and Methods: GSTM1 and GSTT1 deletion polymorphisms were determined by multiplex PCR, whereas GSTO1, GSTO2, and GSTP1 polymorphisms were determined by the real-time PCR in 160 T2DM patients and 248 age- and gender-matched controls. Advanced glycation end products (AGEs) were measured by ELISA. Results: Among six investigated GST polymorphisms, a significant association between the GST genotypes and susceptibility for development of diabetes mellitus was found for the GSTM1, GSTT1, GSTP1 (rs1138272) and GSTO1 polymorphisms. When the GST genotypes’ distribution in diabetes patients was assessed in the subgroups with and without diabetic nephropathy, a significant association was found only for the GSTO2 rs156697 polymorphism. Diabetic patients, carriers of the GSTM1 null, GSTT1 null and variant GSTO1*AA genotypes, had significantly increased levels of AGEs in comparison with carriers of the GSTM1 active, GSTT1 active and referent GSTO1*CC genotypes (p < 0.001, p < 0.001, p = 0.004, respectively). Conclusions: The present study supports the hypothesis that GST polymorphisms modulate the risk of diabetes and diabetic nephropathy and influence the AGEs concentration, suggesting the potential regulatory role of these enzymes in redox homeostasis disturbances.

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“…CXCL10 [76], SIGLEC1 [77] and IL1R2 [78] have been suggested to be associated with neurological diseases. CXCL9 [79], SIGLEC1 [80], IL1R2 [81], KLF15 [82] and CD207 [83] [146], STAT4 [147], CXCL8 [148], KLF2 [149], ADM (adrenomedullin) [150], EGR1 [151], TRIB1 [152], SOD2 [153], OXSR1 [154], IL6R [155], CD44 [156], LRG1 [157], PFKFB2 [158], PACSIN2 [159], MYH9 [160], DOT1L [161], CXCL16 [162], PTEN (phosphatase and tensin homolog) [163], FOXO3 [164], DDIT4 [165], PINK1 [166], IQGAP1 [167], ADIPOR1 [168], MTMR3 [169], USF2 [170], SGK1 [171], GSTO2 [172], ETS2 [173], TKT (transketolase) [174], CMIP (c-Maf inducing protein) [175], THBD (granzyme A) [464], IFNG (interferon gamma) [465], IFIH1 [466], STAT1 [467], CCR5 [468], ADCY5 [469], MT2A [470], DPP4 [471], FASLG (Fas ligand)…”

Section: Discussionmentioning

confidence: 99%

Screening key genes and signaling pathways in COVID-19 infection and its associated complications by integrated bioinformatics analysis

Vastrad¹,

Vastrad²

2021

Preprint

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Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2)/ coronavirus disease 2019 (COVID-19) infection is the leading cause of respiratory tract infection associated mortality worldwide. The aim of the current investigation was to identify the differentially expressed genes (DEGs) and enriched pathways in COVID-19 infection and its associated complications by bioinformatics analysis, and to provide potential targets for diagnosis and treatment. Valid next-generation sequencing (NGS) data of 93 COVID 19 samples and 100 non COVID 19 samples (GSE156063) were obtained from the Gene Expression Omnibus database. Gene ontology (GO) and REACTOME pathway enrichment analysis was conducted to identify the biological role of DEGs. In addition, a protein-protein interaction network, modules, miRNA-hub gene regulatory network, TF-hub gene regulatory network and receiver operating characteristic curve (ROC) analysis were used to identify the key genes. A total of 738 DEGs were identified, including 415 up regulated genes and 323 down regulated genes. Most of the DEGs were significantly enriched in immune system process, cell communication, immune system and signaling by NTRK1 (TRKA). Through PPI, modules, miRNA-hub gene regulatory network, TF-hub gene regulatory network analysis, ESR1, UBD, FYN, STAT1, ISG15, EGR1, ARRB2, UBE2D1, PRKDC and FOS were selected as hub genes, which were expressed in COVID-19 samples relative to those in non COVID-19 samples, respectively. Among them, ESR1, UBD, FYN, STAT1, ISG15, EGR1, ARRB2, UBE2D1, PRKDC and FOS were suggested to be diagonstic factors for COVID-19. The findings from this bioinformatics analysis study identified molecular mechanisms and the key hub genes that might contribute to COVID-19 infection and its associated complications.

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Association of GSTO1 and GSTO2 Polymorphism with Risk of End-Stage Renal Disease Development and Patient Survival

Cited by 8 publications

References 43 publications

Screening for Chronic Kidney Disease in Adult Males in Vojvodina: A Cross-Sectional Study

Screening for Chronic Kidney Disease in Adult Males in Vojvodina: A Cross-Sectional Study

The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk

Screening key genes and signaling pathways in COVID-19 infection and its associated complications by integrated bioinformatics analysis

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