Late-Life Depression: Modifications of Brain Resting State Activity

Cieri, Filippo; Esposito, Roberto; Cera, Nicoletta; Pieramico, Valentina; Tartaro, Armando; Giannantonio, Massimo Di

doi:10.1177/0891988717700509

Cited by 22 publications

(22 citation statements)

References 76 publications

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“…The functional relevance of our findings remains to be confirmed in future studies. LLD is associated with altered functional connectivity patterns in regions of the sensorimotor network . Specifically, greater functional connectivity within the superior parietal lobe (including the primary somatosensory cortex) has been found in LLD and shown to correlate with overall depressive and somatic symptom severity.…”

Section: Discussionmentioning

confidence: 99%

Cortical thickness increases with levomilnacipran treatment in a pilot randomised double‐blind placebo‐controlled trial in late‐life depression

et al. 2019

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Background Late‐life depression (LLD) is associated with significant medical comorbidity, cognitive impairment, and suboptimal treatment response compared to depression experienced earlier in life. Levomilnacipran (LVM) is a novel antidepressant the effects of which on neuroplasticity have not yet been investigated. We investigated the effect of LVM on cortical thickness in a pilot randomised placebo‐controlled trial in LLD. Methods Twenty‐nine adults (≥ 60 years) with major depression (48.3% female; mean age = 71.5 ± 5.8 years; mean education = 16.0 ± 1.7 years) were randomised to either LVM or placebo for 12 weeks. T1‐weighted images were acquired at baseline and 12 weeks. Thirteen subjects (six LVM and seven placebo) completed the study. Group differences in cortical thickness change across the study period were evaluated, with age and total intracranial volume included as covariates. Results Dropout rates did not differ significantly between groups. The LVM group had significantly more side effects, but no serious adverse events were reported. Lower LVM dose (≤ 40 mg) was better tolerated than higher doses (80–120 mg). Additionally, the LVM group showed a larger increase in cortical thickness in the right postcentral gyrus (primary somatosensory), supramarginal gyrus (sensory association region), and lateral occipital cortex (visual cortex) compared to the placebo group and greater reductions in the left insula. Conclusions LVM may be less tolerable by older adults with depression and the effects on cortical thickness across sensory and sensory association regions may be related to the experience of side effects. Larger studies are necessary to evaluate treatment efficacy, tolerability, and neural effects of LVM in LLD.

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Section: Discussionmentioning

confidence: 99%

Cortical thickness increases with levomilnacipran treatment in a pilot randomised double‐blind placebo‐controlled trial in late‐life depression

et al. 2019

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“…However, connectivity between the SN (i.e., anterior insula, dorsal ACC) and the anterior nodes of DMN [ 82 ] as well as between the insula and the amygdala [ 83 ] seems enhanced in depressed individuals when compared with controls and these results are coherent with the more engagement in mentalizing about the self and past autobiographical experiences and focusing on negative thoughts demonstrated in these patients. In our recent study [ 37 ] we showed a significant modification in the left FPN (lFPN) characterized by increased connectivity in the left Superior Parietal Lobule (SPL) and left DLPFC in LLD group ( Figure 4 ). The lFPN is implicated in language and working memory processing [ 84 , 85 ] and the significant modification found in our study could justify some typical cognitive symptoms in LLD, assuming an inability to regulate the activation of an important area for specific cognitive tasks, as the case of working memory, impaired in LLD, MCI, and AD.…”

Section: Late Life Depressionmentioning

confidence: 90%

“…Contrast maps are overimposed on Talairach template (T1 weighted images) in radiological convention. The figures are derived from the following study: [ 37 ].…”

Section: Figurementioning

confidence: 99%

Neuroaging through the Lens of the Resting State Networks

Cieri¹,

Esposito

2018

BioMed Research International

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Resting state functional magnetic resonance imaging (rs-fMRI) allows studying spontaneous brain activity in absence of task, recording changes of Blood Oxygenation Level Dependent (BOLD) signal. rs-fMRI enables identification of brain networks also called Resting State Networks (RSNs) including the most studied Default Mode Network (DMN). The simplicity and speed of execution make rs-fMRI applicable in a variety of normal and pathological conditions. Since it does not require any task, rs-fMRI is particularly useful for protocols on patients, children, and elders, increasing participant's compliance and reducing intersubjective variability due to the task performance. rs-fMRI has shown high sensitivity in identification of RSNs modifications in several diseases also in absence of structural modifications. In this narrative review, we provide the state of the art of rs-fMRI studies about physiological and pathological aging processes. First, we introduce the background of resting state; then we review clinical findings provided by rs-fMRI in physiological aging, Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD), and Late Life Depression (LLD). Finally, we suggest future directions in this field of research and its potential clinical applications.

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“…While structural alterations reflect the long-term influence of depression, and task-based imaging profiles the altered brain reaction to external stimuli or under specific situations, resting-state fMRI explores the intrinsic changes of brain activity in the state without any influence of external stimuli. Resting-state fMRI studies using the method of independent component analysis has revealed that the default mode network, the frontoparietal network and the sensorimotor network showed abnormal connectivity in LLD patients (12,13). LLD patients also exhibited abnormal local synchronization in various brain areas, as revealed by the measure of regional homogeneity (14).…”

Section: Introductionmentioning

confidence: 99%

Abnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Gong

et al. 2020

Front. Psychiatry

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Objectives: Late-life depression (LLD) has negative impacts on somatic, emotional and cognitive domains of the lives of patients. Elucidating the abnormality in the brain networks of LLD patients could help to strengthen the understanding of LLD pathophysiology, however, the studies exploring the spontaneous brain activity in LLD during the resting state remain limited. This study aimed at identifying the voxel-level whole-brain functional connectivity changes in LLD patients. Methods: Fifty patients with late-life depression (LLD) and 33 healthy controls were recruited. All participants underwent a resting-state functional magnetic resonance imaging scan to assess the voxel-wise degree centrality (DC) changes in the patients. Furthermore, DC was compared between two patient subgroups, the late-onset depression (LOD) and the early-onset depression (EOD). Results: Compared with the healthy controls, LLD patients showed increased DC in the inferior parietal lobule, parahippocampal gyrus, brainstem and cerebellum (p < 0.05, AlphaSim-corrected). LLD patients also showed decreased DC in the somatosensory and motor cortices and cerebellum (p < 0.05, AlphaSim-corrected). Compared with EOD patients, LOD patients showed increased centrality in the superior and middle temporal gyrus and decreased centrality in the occipital region (p < 0.05, AlphaSim-corrected). No significant correlation was found between the DC value and the symptom severity or disease duration in the patients after the correction for multiple comparisons. Conclusions: These findings indicate that the intrinsic abnormality of network centrality exists in a wide range of brain areas in LLD patients. LOD patients differ with EOD patients

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Late-Life Depression: Modifications of Brain Resting State Activity

Cited by 22 publications

References 76 publications

Cortical thickness increases with levomilnacipran treatment in a pilot randomised double‐blind placebo‐controlled trial in late‐life depression

Cortical thickness increases with levomilnacipran treatment in a pilot randomised double‐blind placebo‐controlled trial in late‐life depression

Neuroaging through the Lens of the Resting State Networks

Abnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study

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