Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes

“…4 Finally, in a nationwide study conducted in Denmark, 4vHPV during pregnancy was not associated with significantly greater risks of adverse pregnancy outcomes, including major birth defects and spontaneous abortion. 5 Overall, the existing safety data do not suggest an increased risk of spontaneous abortion, fetal malformations, or adverse pregnancy outcomes beyond that found in the general population. 6 These prior studies have some potential limitations, however.…”

Section: Introductionmentioning

confidence: 93%

Postlicensure safety surveillance of congenital anomaly and miscarriage among pregnancies exposed to quadrivalent human papillomavirus vaccine

Meyer

Klein

et al. 2017

Human Vaccines & Immunotherapeutics

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Limited safety data are available on inadvertent exposure to quadrivalent human papillomavirus vaccine (4vHPV) during pregnancy. We conducted a descriptive observational postlicensure safety surveillance study in Kaiser Permanente Southern California and Northern California to assess congenital anomaly and miscarriage among pregnancies exposed to 4vHPV. Using electronic medical records, we identified women who received a dose of 4vHPV between August 2006 and March 2008 within 30 days preconception or any time during a possible pregnancy. A broad algorithm was developed using diagnostic and procedure codes and laboratory tests to identify pregnancy, congenital anomalies, and miscarriages. Medical records of all potential congenital anomaly cases and a random sample of 100 potential miscarriage cases were reviewed to confirm pregnancy exposure and diagnosis. Results were reviewed by an independent Safety Review Committee (SRC). Among the population of 189,629 females who received at least one dose of 4vHPV during the study period, 2,678 females were identified as possibly having a 4vHPV-exposed pregnancy. Among 170 potential congenital anomalies identified, 44 (26%) were found to be both 4vHPV-exposed and confirmed congenital anomaly cases. Among the 633 potential miscarriages identified, the records of a random sample of 100 cases were reviewed, and 9 cases (9%) were confirmed as 4vHPV-exposed miscarriages. The SRC noted no safety signal for congenital anomaly or miscarriage associated with 4vHPV exposure during pregnancy. The rate of major congenital anomaly (3.6%) was in the range of background estimates from the literature. There was no apparent pattern of timing of 4vHPV exposure among 4vHPV-exposed miscarriages.

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“…In diesen Studien zeigte sich, dass eine Impfung selbst kurz vor oder während einer Schwangerschaft keine negativen Auswirkungen auf die Entwicklung des Kindes oder den Schwangerschaftsverlauf hat [10] [11]. Ebenso wenig sind teratogene Effekte zu befürchten [12].…”

Section: Rolle Der Hpv-infektion In Der Hebammenarbeitunclassified

Humane Papillomviren und Schwangerschaft

Mau¹

2019

Hebamme

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Humane Papillomviren (HPV) gehören zu den am häufigsten übertragenen sexuellen Infektionserregern weltweit. Schätzungsweise drei von vier Menschen im sexuell aktiven Alter sind mit einem oder mehreren der über 200 HPV-Typen infiziert 1. Wichtig für Hebammen: Es gibt auch nicht-sexuelle Übertragungswege. Einige dieser Viren stehen zudem im Verdacht, die Fruchtbarkeit von Mann und Frau sowie den Verlauf einer Schwangerschaft negativ zu beeinflussen. Die HPV-Impfung schützt vor der Infektion und den gesundheitlichen Folgen einiger dieser HP-Viren. Doch ist die Impfung für Schwangere überhaupt sicher und damit empfehlenswert?

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Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes

Cited by 79 publications

References 16 publications

Challenges of independent assessment of potential harms of HPV vaccines

Challenges of independent assessment of potential harms of HPV vaccines

Postlicensure safety surveillance of congenital anomaly and miscarriage among pregnancies exposed to quadrivalent human papillomavirus vaccine

Humane Papillomviren und Schwangerschaft

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