Endoscopic diagnosis and treatment of neuroendocrine tumors of the digestive system

Sivero, Luigi; Telesca, Donato Alessandro; Ruggiero, Simona; Russo, Teresa; Amato, Maurizio; Bianco, Tommaso; Amato, Bruno; Formisano, Cesare; Avellino, Manuela; Napolitano, Vincenzo

doi:10.1515/med-2016-0067

Cited by 3 publications

(3 citation statements)

References 12 publications

(8 reference statements)

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“…Endoscopically, neuroendocrine tumors of the digestive tract can present as polypoid forms, nodules, masses, ulcers, or stenosis, and they can be single or multiple and range in size from a few millimeters to several centimeters. These tumors, which are rare in the esophagus (only 50 cases have been documented), typically form sessile polypoid structures in the lower third 16 .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of non-gastric upper gastrointestinal system polyps: an epidemiological assessment

Erdoğan

Arı

YEŞİL

et al. 2023

Sci Rep

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Non-gastric upper gastrointestinal system polyps are detected rarely and mostly incidentally during upper gastrointestinal endoscopy. While the majority of lesions are asymptomatic and benign, some lesions have the potential to become malignant, and may be associated with other malignancies. Between May 2010 and June 2022, a total of 127,493 patients who underwent upper gastrointestinal endoscopy were retrospectively screened. Among these patients, those who had polyps in the esophagus and duodenum and biopsied were included in the study. A total of 248 patients with non-gastric polyps were included in this study. The esophageal polyp detection rate was 80.00/100,000, while the duodenal polyp detection rate was 114.52/100,000. In 102 patients (41.1%) with esophageal polyps, the mean age was 50.6 ± 15.1, and 44.1% (n = 45) were male. The most common type of polyps was squamous papilloma (n = 61, 59.8%), followed by inflammatory papilloma (n = 18, 17.6%). In 146 patients (58.9%) with duodenal polyps, the mean age of patients was 58.3 ± 16.5, and 69.8% (n = 102) were male. Brunner's gland hyperplasia, inflammatory polyp, ectopic gastric mucosa, and adenomatous polyp were reported to be the most prevalent types of polyps in the duodenum overall (28.1%, 27.4%, 14.4%, and 13.7%, respectively). It is crucial to identify rare non-gastric polyps and create an effective follow-up and treatment plan in the era of frequently performed upper gastrointestinal endoscopies. The epidemiological assessment of non-gastric polyps, as well as a follow-up and treatment strategy, are presented in this study.

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Section: Introductionmentioning

confidence: 99%

“…They typically occur in the I and II duodenal sections, preferring the peripapillary region, and under endoscopic vision, they show as a single, small lesion (frequently less than 1 cm in size). Additionally, they may exist in groups or be linked to neuroendocrine tumors in other organs 16 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of non-gastric upper gastrointestinal system polyps: an epidemiological assessment

Erdoğan

Arı

YEŞİL

et al. 2023

Sci Rep

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“…Endoscopic examinations such as capsule endoscopy and double-balloon enteroscopy are useful in identifying occult SB-NENs when no primary tumor was found on conventional imaging. Macroscopically, most SB-NENs are sessile nodules or ulcerated lesions usually measuring between 1 and 2 cm or as multiple tumors[ 27 , 28 ].…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis, treatment, and current concepts in the endoscopic management of gastroenteropancreatic neuroendocrine neoplasms

Iabichino¹,

Leo²,

Arena³

et al. 2022

WJG

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Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare tumors derived from the neuroendocrine cell system, which that have increased in incidence and prevalence in recent years. Despite improvements in radiological and metabolic imaging, endoscopy still plays a pivotal role in the number of GEP-NENs. Tumor detection, characterization, and staging are essential in management and treatment planning. Upper and lower gastrointestinal (GI) endoscopy is essential for correct localization of the primary tumor site of GI NENs. Endoscopic ultrasonography (EUS) has an important role in the imaging and tissue acquisition of pancreatic NENs and locoregional staging of GI neuroendocrine tumors. Correct staging and histological diagnosis have important prognostic implications. Endoscopic operating techniques allow the removal of small GI NENs in the early stage of mucosal or submucosal invasion of the intestinal wall. Preoperative EUS-guided techniques may help the surgeon locate small and deep tumors, thus avoiding formal pancreatic resections in favor of parenchymal-sparing surgery. Finally, locoregional ablative treatments have been proposed in recent studies with promising results in selected patients.

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Virus-associated neuroendocrine cancers: Pathogenesis and current therapeutics

Banerjee

Ranjan

Alam

et al. 2023

Pathology - Research and Practice

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Endoscopic diagnosis and treatment of neuroendocrine tumors of the digestive system

Cited by 3 publications

References 12 publications

Evaluation of non-gastric upper gastrointestinal system polyps: an epidemiological assessment

Evaluation of non-gastric upper gastrointestinal system polyps: an epidemiological assessment

Diagnosis, treatment, and current concepts in the endoscopic management of gastroenteropancreatic neuroendocrine neoplasms

Virus-associated neuroendocrine cancers: Pathogenesis and current therapeutics

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