Effect of topiramate on choroidal thickness and anterior chamber parameters in the treatment of patients with migraine

Gök, Mustafa; Özdemir, Özdemir

doi:10.1080/15569527.2017.1311337

Cited by 3 publications

(5 citation statements)

References 24 publications

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“…The findings of our study were in agreement with many previous case reports [18][19][20][21][22][23][24][25] and one of the previous published prospective studies [14]. On the contrary, other studies described changes that were not found in our study [15][16][17]. Those studies found significant ocular side effects induced by TPM including changes in the size of the ciliary body, ACD, RF, and IOP.…”

Section: Discussionsupporting

confidence: 93%

“…The difference in the ethnic groups might also explain the difference between the previous studies itself. Leung et al did not find any significant changes in a Chinese group of patients, like our study; however, the other two studies done for Turkish patients and the one done for Iranian patients found some significant changes in various ophthalmological parameters [14][15][16][17].…”

Section: Discussioncontrasting

confidence: 48%

“…Leung et al did not describe any significant changes in the depth of anterior chamber in a Chinese group of patients after 1-month use of a fixed dose (50 mg/day) of TPM [14]. Another two studies done for Turkish patients: one reported both acute (within 1 week) increase in the thickness of the ciliary body and decrease in the angle of the anterior chamber using a fixed dose of TPM (50 mg/day), and the other one found a significant increase in the intraocular pressure (IOP) and decrease in the anterior chamber depth (ADC) after 1 and 2 months of use of a fixed dose of TPM (50 mg/day) in patients with migraine [15,16]. Last study included an Iranian group of patients with migraine.…”

Section: Introductionmentioning

confidence: 99%

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Topiramate-induced ocular side effects in Egyptian patients, idiosyncratic versus dose-dependent effect, a prospective study

Thabit

Farouk

2021

Egypt J Neurol Psychiatry Neurosurg

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Background To test the nature of the ocular side effects induced by topiramate (TPM) whether dose dependent or idiosyncratic, and to test various predictors that might influence the occurrence of those side effects. Methods Twenty patients treated with TPM were included in this study. Patients underwent ophthalmic assessment before and after 4 weeks of treatment by stable doses of oral TPM. We examined non-cycloplegic refraction (RF) in diopters, best corrected visual acuity (BCVA), intraocular pressure (IOP) in mmHg, and anterior chamber depth (ACD) in mm. Results There were no statistically significant differences between baseline and follow-up assessments in all tested ophthalmological parameters including errors of RF, ACD, IOP, and the BCVA. One case suffered from painful drop of vision in both eyes with elevated IOP and decreased ACD, and evident myopic shift 1 week after treatment with small dose of TPM. There was no significant effect of age, TPM dose, disease, and gender on all tested variables. Conclusion TPM can induce idiosyncratic, but not dose dependent, ocular side effects, namely myopic shifts and angle closure glaucoma. Those side effects were not disease, age, or gender dependent. However, ethnicity might play a role in induction of those side effects.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

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Topiramate-induced ocular side effects in Egyptian patients, idiosyncratic versus dose-dependent effect, a prospective study

Thabit

Farouk

2021

Egypt J Neurol Psychiatry Neurosurg

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“…In this study, iris adhesions were associated with TPM, moreover, iris disorder and iris atrophy were both showed positive signals, indicating that TPM probably had effect on iris. Some studies revealed that TPM could decrease or alter the anterior chamber angle, and these effects might be asymptomatic [19,20]. In this study, we verified the results with strong signals emerging in narrow anterior chamber angle and flat anterior chamber of eye.…”

Section: Discussionsupporting

confidence: 83%

Eye Disorders Associated with newer Antiepileptic drugs: A real-world disproportionality analysis of FDA Adverse Reporting System events

Chen

Meana

Humberto

et al. 2021

Proceedings of MOL2NET'21, Conference on Molecular, Biomedical &Amp; Computational Sciences and Engineering, 7th Ed.

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BackgroundNewer antiepileptic drugs (AEDs), such as Levetiracetam (LEV), Lacosamide(LCM), Topiramate(TPM), Gabapentin(GBP), Oxcarbazepine(OXA), Lamotrigine(LTG) and Zonisamide(ZNS), are prescribed frequently for epilepsy by physicians. Simultaneously, they are known to be associated with a series of eye disorders. But very few studies have systemically compared eye disorders of newer AEDs in a large sample of patients diagnosed with epilepsy. ObjectiveThe aim of this study is to evaluate the association between eye disorders and several newer antiepileptic drugs (AEDs), including LEV, LTG, TPM, GBP, OXA, LCM, ZNS, as well as to look for differences in the frequency of AEs across individual AEDs, by data-mining a self-reporting database, the FDA Adverse Event Report System (FAERS). MethodsThe definition relied on system organ class (SOCs) and preferred terms (PTs) by the Medical Dictionary for Regulatory Activities (MedDRA). Disproportionality analysis was used to detect the risk signals from the data in the US Food and Drug Administration (FDA) adverse event reporting system database (FAERS). The reporting odds ratio (ROR), the proportional reporting ratio (PRR) and χ2 (chi-square) were calculated to assess the association between adverse events (AEs) and AEDs use. ResultsFAERS reports of 158095 cases from January 1, 2015 to September 30, 2020 were included in this study. AEDs were associated with a series of eye related adverse events (AEs) defined by 106 Preferred Terms, which could be classified into ten aspects ： Anterior eye structural change, deposit and degeneration, Glaucoma and ocular hypertension, Ocular haemorrhages and vascular disorders NEC (Not Elsewhere Classified), Ocular infections, irritations and inflammations, Ocular neuromuscular disorders, Ocular sensory symptoms NEC, Ocular structural change, deposit and degeneration NEC, Retina, choroid and vitreous haemorrhages and vascular disorders, Vision disorders, Eye disorders NEC. ConclusionEye disorders occupy a certain proportion compared with other AEs associated with AEDs. There is variation in the types and severity of eye related AEs across individual AEDs. Generally, TPM and LTG are more likely to cause either mild or serious eye-related AEs. Patients with ophthalmic diseases should avoid using TPM and LTG. By contrast, LCM rarely has any severe eye related AEs, only diplopia and metamorphopsia are significant. LEV tend to produce ocular neuromuscular disorders related AEs. The adverse effects to macula induced by GBP should be taken into consideration during the clinic practice. ZNS appears to be heavily associated with choroidal effusion and angle closure glaucoma. OXA is mainly associated with lid lag and several cornea-related AEs.

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“…Therefore, we presumed that TPM likely had no direct effect on the iris and instead affected the function of the iris from a common inflammatory mechanism. Certain studies have revealed that TPM can decrease or alter the anterior chamber angle, and these effects may be asymptomatic [22,23].…”

Section: Discussionmentioning

confidence: 99%

Eye disorders associated with newer antiepileptic drugs: A real-world disproportionality analysis of FDA adverse event reporting system

Chen

et al. 2022

Seizure

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Effect of topiramate on choroidal thickness and anterior chamber parameters in the treatment of patients with migraine

Abstract: The study revealed increased CT and altered anterior chamber parameters and IOP due to topiramate therapy. Therefore, the patients using topiramate should be carefully monitored by an ophthalmologist considering the possible side effects.

Cited by 3 publications

References 24 publications

Topiramate-induced ocular side effects in Egyptian patients, idiosyncratic versus dose-dependent effect, a prospective study

Topiramate-induced ocular side effects in Egyptian patients, idiosyncratic versus dose-dependent effect, a prospective study

Eye Disorders Associated with newer Antiepileptic drugs: A real-world disproportionality analysis of FDA Adverse Reporting System events

Eye disorders associated with newer antiepileptic drugs: A real-world disproportionality analysis of FDA adverse event reporting system

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