Anti-hepatoma activities of ethyl acetate extract from Ampelopsis sinica root

Wang, Jiazhi; Huang, Bisheng; Cao, Yanjun; Li, Juan

doi:10.3892/or.2017.5504

Cited by 8 publications

(3 citation statements)

References 35 publications

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“…This species has been found in Anhui, Chongqing, Sichuan, Taiwan and other provinces in China [94] Notes: Ampelopsis sinica root (ASR) is a traditional Chinese medicine known to have a hepatoprotective function. Moreover, it has been proven having anti-hepatocellular carcinogenic activity and to inhibit Hepatitis B virus activity [95][96][97]. Our rust collection (GMB00110) on Ampelopsis sinica is compatible with Neophysopella ampelopsidis [98].…”

Section: Taxonomymentioning

confidence: 99%

Rust Fungi on Medicinal Plants in Guizhou Province with Descriptions of Three New Species

Wu,

He,

Liu

et al. 2023

JoF

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During the research on rust fungi in medicinal plants of Guizhou Province, China, a total of 9 rust fungal species were introduced, including 3 new species (Hamaspora rubi-alceifolii, Nyssopsora altissima, and Phragmidium cymosum), as well as 6 known species (Melampsora laricis-populina, Melampsoridium carpini, Neophysopella ampelopsidis, Nyssopsora koelrezidis, P. rosae-roxburghii, P. tormentillae). Notably, N. ampelopsidis and P. tormentillae were discovered for the first time in China, while M. laricis-populina, Me. carpini, and Ny. koelreuteriae were first documented in Guizhou Province. Morphological observation and molecular phylogenetic analyses of these species with similar taxa were compared to confirm their taxonomic identities, and taxonomic descriptions, illustrations and host species of those rust fungi on medicinal plant are provided.

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Section: Taxonomymentioning

confidence: 99%

Rust Fungi on Medicinal Plants in Guizhou Province with Descriptions of Three New Species

Wu,

He,

Liu

et al. 2023

JoF

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“…Following treatment, the relative viability (to vehicle control group) of the cells was detected according to the kit manufacturer's instructions. The relative cell viability was calculated using the following formula: relative cell viability (%) = (1 -(OD control -OD treated )/ OD control ) × 100% [16].…”

Section: Cell Viability Testmentioning

confidence: 99%

Bcl-2 is essential for Foeniculum vulgare seed extract-induced apoptosis in lung cancer

Zhao

2020

Preprint

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Background The factors behind the pathogenesis of lung cancer are not clear, and treatment failure is generally caused by drug resistance, recurrence, and metastasis. Development of new therapeutic agents to overcome drug-resistance remains a challenge clinically. Various extracts of Foeniculum vulgare have shown promising anticancer activity; however, effects on lung cancer and the underlying molecular mechanisms of action are not clear. Methods The cytotoxicity effects of EEFS were assessed by morphological changes or MTT assay. The BALB/c nude mice xenograft model was used for the in vivo study. Apoptotic ratio assay based on Annexin V-PI staining were measured by flow cytometry. Effect of EEFS on expression of apoptotic proteins was measured by Western blot. Mitochondria toxicity was evaluated by fluorescence to show membrane potential under a fluorescent microscope and Cytochrome C release. Results We found that the ethanol extract of Foeniculum vulgare seeds (EEFS) significantly reduced lung cancer cell growth in vitro and in vivo. EEFS decreased the viability of and triggered apoptosis in the lung cancer cell lines NCI-H446 and NCI-H661. EEFS induced apoptosis mainly through inhibition of Bcl-2 protein expression, reduction of mitochondrial membrane potential, and release of Cytochrome C. Moreover, EEFS significantly inhibited colony formation and cell migration in lung cancer cells. EEFS also effectively inhibited the growth of xenograft tumors derived from NCI-446 cells by reducing Bcl-2 protein expression and inducing apoptosis. Conclusions Taken together, these findings suggest that EEFS exerts anti-lung cancer activity by targeting the Bcl-2 protein and may have potential as a therapeutic drug for lung cancer.

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“…The findings showed that ASRE had prominent antihepatoma activity, which possibly involved the decreased regulation of inflammatory cytokines such as cyclooxygenase-2, 5-lipoxygenase and FLAP, augment of p53 protein expression and the ratio of bax/bcl-2, caspase-3 activation, as well as survivin repression. Moreover, ASR was found to be nontoxic on normal cells, suggesting that it may serve as a potential therapeutic agent for HCC treatment [55].…”

Section: Functional Roles Of Chinese Medicine Extracts and Fractions mentioning

confidence: 99%

What Chinese Medicine Can Do for Liver Cancer?

Chen¹,

Wang²,

Feng³

2018

Liver Cancer

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Liver cancer is an international problem, especially in Asian countries. It is because that most liver cancers are already late stage when they are diagnosed, and also most liver cancers have various previous chronic liver diseases induced by alcoholic, virus, and steatosis, etc. In recent years, laboratory and clinical studies focusing on liver cancer by Chinese medicine has been extensively studied. What Chinese medicine treatment formalities can be used in liver cancer? How Chinese medicine can be employed in treatment of liver cancer? What Chinese medicine can contribute to liver cancer? To answer these questions in this chapter, we will review and discuss treatment of liver cancer from Chinese medicine's perspective with scientific evidences as following three parts: (1) Chinese medicine as the source of discovering new treatment for liver cancer, (2) Chinese medicine as a complementary treatment of liver cancer, and (3) to discuss future research and application of Chinese medicine in liver cancer treatment.

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Anti-hepatoma activities of ethyl acetate extract from Ampelopsis sinica root

Cited by 8 publications

References 35 publications

Rust Fungi on Medicinal Plants in Guizhou Province with Descriptions of Three New Species

Rust Fungi on Medicinal Plants in Guizhou Province with Descriptions of Three New Species

Bcl-2 is essential for Foeniculum vulgare seed extract-induced apoptosis in lung cancer

What Chinese Medicine Can Do for Liver Cancer?

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