Preparation of Drug-Loaded PLGA-PEG Nanoparticles by Membrane-Assisted Nanoprecipitation

Abstract

The method allowed to produce polymeric nanoparticles for drug delivery with a high productivity, reproducibility and easy scalability.

Poly (lactic-co-glycolic acid) nanospheres allow for high l-asparaginase encapsulation yield and activity

“…(5) was < 0.5 (n = 0.291), which indicates a pseudo-Fickian diffusion behavior where sorption curves resemble Fickian curves, but the approach to final equilibrium is very slow [32]. According to Albisa et al [33], pseudo-Fickian behavior predominates when additional effects of swelling, erosion, degradation, stresses, structural changes and relaxation of the material are present.…”

Antagonistic Effect of Azoxystrobin Poly (Lactic Acid) Microspheres with Controllable Particle Size on Colletotrichum higginsianum Sacc

“…The PDIs of MS1 and MS2 aqueous dispersions were measured to be 0.10 ± 0.02 and 0.07 ± 0.05, showing monodispersity via SPG emulsification. As previously reported, the dexamethasone-poly[( d , l -lactide-co-glycolide)-co-poly ethylene glycol] (DEX-PLGA-PEG) nanoparticles were prepared by SPG membrane-assisted nanoprecipitation with PDI lower than 0.2 [ 33 ]. In addition, avermectin starch microparticles were fabricated by SPG membrane emulsification with PDI lower than 0.1 [ 34 ].…”

Nanoprecipitation: Applications for Entrapping Active Molecules of Interest in Pharmaceutics

“…Figure 2 shows in a comparative way the reported starting materials used to prepare the different types of particles via nanoprecipitation. As can be seen, PLGA, PCL, and PLA are the most used polymers to prepare polymeric nanoparticles and when these polymers are chemically modified with, for example, PEG, stealth polymeric nanoparticles can be obtained [16,17,27]. Surfactants of low HLB value, e.g., soy phospholipids, could be added to the organic phase for facilitating the particle formation [19,31] and, if nanocapsules are intended, castor oil, sesame oil, caprylic capric triglycerides, and caprylic capric triglyceride PEG-4 esters are part of the organic phase.…”

“…Some of the research works undertaken during the last years have proposed the vectorization in nanoparticles, via nanoprecipitation, of hydrophobic active molecules, mainly exhibiting logP values higher than 3. They include antineoplastics (e.g., doxorubicin [4], paclitaxel [5,6], docetaxel [7,8], methotrexate [9], triptolide [6], cucurbitacin [10], and sorafenib [11]), antiretrovirals (e.g., efavirenz [12] and nevirapine [13]), immune suppressants (mycophenolate [14]), anti-inflammatories (clobetasol [15], fluticasone propionate [16], dexamethasone [17,18], and diclofenac [19]), antimicrobial and antifungal agents (polymyxin B [20], amphotericin B [21], itraconazole [22], and linezolid [23]), antihyperlipidemics (fenofibrate [24,25]), anesthetics (tetracaine [26] and ketamine [27]), antihypertensives (nimodipine [28] and atenolol [29]), vitamins or their precursors (β-carotene [30] and vitamin E [31]), and antioxidants (quercetin [14,32]). Likewise, although in a much smaller number, hydrophilic active molecules such alendronate [33], N-acetylcysteine [34], and calcein [35], have been investigated.…”