Functional oligopeptide as a novel strategy for drug delivery

Ji, Yujie; Qiao, Hongzhi; He, Jiangjiang; Li, Weidong; Chen, Rui; Wang, Jingjing; Wu, Li; Hu, Rongfeng; Duan, Jin‐Ao; Chen, Zhipeng

doi:10.1080/1061186x.2017.1309044

Cited by 15 publications

(11 citation statements)

References 84 publications

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“…However, some studies have reported that oligopeptides show an acceptable in vivo stability and integrity, good tissue penetration to exert their effects and a low toxicity. Additionally, they have gained wide attention for drug delivery systems and different modifications can be easily applied to improve their pharmacological profile [52]. All of these properties are relevant regarding potential therapeutic applications.…”

Section: Discussionmentioning

confidence: 99%

Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis

Nácher-Juan

Terencio

Alcaraz

et al. 2019

IJMS

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In chronic inflammatory joint diseases, such as rheumatoid arthritis, there is an important bone loss. Parathyroid hormone-related protein (PTHrP) and related peptides have shown osteoinductive properties in bone regeneration models, but there are no data on inflammatory joint destruction. We have investigated whether the PTHrP (107-111) C-terminal peptide (osteostatin) could control the development of collagen-induced arthritis in mice. Administration of osteostatin (80 or 120 μg/kg s.c.) after the onset of disease decreased the severity of arthritis as well as cartilage and bone degradation. This peptide reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes. The levels of key cytokines, such as interleukin(IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws were decreased by osteostatin treatment, whereas IL-10 was enhanced. Bone protection was related to reductions in receptor activator of nuclear factor-κB ligand, Dickkopf-related protein 1, and joint osteoclast area. Osteostatin improves arthritis and controls bone loss by inhibiting immune activation, pro-inflammatory cytokines, and osteoclastogenesis. Our results support the interest of osteostatin for the treatment of inflammatory joint conditions.

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Section: Discussionmentioning

confidence: 99%

Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis

Nácher-Juan

Terencio

Alcaraz

et al. 2019

IJMS

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“…Various studies preferred oligopeptides for their properties such as specific targeting, cell penetration, selfassembled capacity, and responsiveness to the environment. Moreover, methods to target tumor neovasculature, cells, and organelles were summarized [47].…”

Section: Health Benefits and Applicationsmentioning

confidence: 99%

Research Trends in Plant-Derived Oligomers for Health Applications

Köse

Hardy

Sheridan

et al. 2021

CNT

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Objective: Epidemiological data illustrates that there is a strong relationship between dietary intake of natural bioactive compounds and their beneficial properties against various diseases, and this stimulates academic and industrial interest in using plant-derived compounds for health and medicine. For this reason, recent health related studies in the literature have focused on a variety of many plant-derived bioactive compounds. Even though the bioactivities of such compounds have widely been investigated, there are few studies about oligomeric species and their activities. Methods: In this review, extraction and isolation methods of the plant-derived oligomers and the use of such oligomers in health applications is summarised. Results: In the literature, many studies state that oligomeric compounds have beneficial to human health. To maximize these beneficial properties, various ways to use oligomeric compounds have been examined and summarised. Conclusion: A better understanding of the specific activities of distinct components of plant-derived oligomers is expected to open new avenues for drug discovery. This review gives an overview of oligomers with health beneficial properties and their possible applications in healthcare.

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“… 6 However, these methods have been less impactful in the field of oligopeptide drug development due to issues including the relatively small amount of available data for oligopeptide drugs and the fact that the very short lengths of oligopeptides result in relatively few of the distinguishable features that are exploited by common machine learning approaches. 7 Thus, the development of an automatic design strategy for oligopeptide drugs would be useful.…”

Section: Introductionmentioning

confidence: 99%

Generation of functional oligopeptides that promote osteogenesis based on unsupervised deep learning of protein IDRs

et al. 2022

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Deep learning (DL) is currently revolutionizing peptide drug development due to both computational advances and the substantial recent expansion of digitized biological data. However, progress in oligopeptide drug development has been limited, likely due to the lack of suitable datasets and difficulty in identifying informative features to use as inputs for DL models. Here, we utilized an unsupervised deep learning model to learn a semantic pattern based on the intrinsically disordered regions of ~171 known osteogenic proteins. Subsequently, oligopeptides were generated from this semantic pattern based on Monte Carlo simulation, followed by in vivo functional characterization. A five amino acid oligopeptide (AIB5P) had strong bone-formation-promoting effects, as determined in multiple mouse models (e.g., osteoporosis, fracture, and osseointegration of implants). Mechanistically, we showed that AIB5P promotes osteogenesis by binding to the integrin α5 subunit and thereby activating FAK signaling. In summary, we successfully established an oligopeptide discovery strategy based on a DL model and demonstrated its utility from cytological screening to animal experimental verification.

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Functional oligopeptide as a novel strategy for drug delivery

Cited by 15 publications

References 84 publications

Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis

Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis

Research Trends in Plant-Derived Oligomers for Health Applications

Generation of functional oligopeptides that promote osteogenesis based on unsupervised deep learning of protein IDRs

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