American College of Radiology  Contrast Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) for the diagnosis of Hepatocellular Carcinoma: a pictorial essay

Piscaglia, Fabio; Wilson, Stephanie R.; Lyshchik, Andrej; Cosgrove, David O.; Dietrich, Christoph F.; Jang, Hyun‐Jung; Kim, Tae Kyoung; Salvatore, Veronica; Willmann, Jüergen K.; Sirlin, Claude B.; Kono, Yuko

doi:10.1055/s-0042-124661

Cited by 86 publications

(77 citation statements)

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“…The liver imaging reporting and data system (LI-RADS) is a comprehensive algorithm which provides tools for standardizing the imaging diagnosis of patients at risk for HCC, and it is now completely concordant with the American Association for the Study of Liver Diseases (AASLD) guidance for the definite diagnosis and management of HCC [10,11]. The latest versions of LI-RADS (LI-RADS v2017 and 2018) [12], in addition to updated criteria for HCC diagnosis, also provide precise imaging criteria for assigning category LR-M (probable or definite malignancy, not specific for HCC).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of LI-RADS version 2018 in differentiating hepatocellular carcinoma from other hepatic malignancies in patients with hepatitis B virus infection

Shao

Liang

Kuang

et al. 2020

Bosn J of Basic Med Sci

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The diagnostic performance of the Liver Imaging Reporting and Data System (LI-RADS) in differentiating hepatocellular carcinoma (HCC) from other hepatic malignancies has not been investigated in Chinese patients with chronic liver disease from hepatitis B virus (HBV) infection. The aim of this study was to evaluate the accuracy of the LI-RADS version 2018 in differentiating HCC, intrahepatic cholangiocarcinoma (ICCA), and combined HCC-cholangiocarcinoma (cHCC-CCA) in Chinese patients with HBV infection. Seventy consecutive HBV-infected patients with ICCA (n = 48) or cHCC-CCA (n = 22) who underwent contrast-enhanced magnetic resonance imaging (CE-MRI) between 2006 and 2017 were enrolled along with a comparison cohort of 70 patients with HCC and CE-MRI-matched for tumor size (10–19 mm, 20–30 mm, 31–50 mm, and >50 mm). Imaging feature frequencies for each tumor type were compared using Fisher’s exact test. The classification accuracy of LR-5 and LR-M was estimated for HCC versus non-HCC (ICCA and cHCC-CCA). The interobserver agreement was good for LI-RADS categories of HCC, and moderate for non-HCC. After consensus read, 66 of 70 (94%) HCCs were categorized LR-5 (including tumor in vein [TIV] with LR-5), while 42 of 48 (88%) ICCAs and 13 of 22 (59%) cHCC-CCAs were categorized LR-M (including TIV with LR-M) (p < 0.001). Thus, assignment of LR-5 provided 94% sensitivity and 81% specificity for HCC. LR-M provided 79% sensitivity and 97% specificity for non-HCC (ICCA and cHCC-CCA); and the sensitivity and accuracy were lower in differentiating HCC from non-HCC (tumor size <20 mm). LI-RADS v2018 category 5 and M reliably differentiated HBV-related HCC from ICCA. However, a substantial proportion of cHCC-CCAs were categorized LR-5 rather than LR-M. While management is controversial for these combined tumors, accurate prospective differentiation is desired for optimal treatment.

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Section: Introductionmentioning

confidence: 99%

Diagnostic performance of LI-RADS version 2018 in differentiating hepatocellular carcinoma from other hepatic malignancies in patients with hepatitis B virus infection

Shao

Liang

Kuang

et al. 2020

Bosn J of Basic Med Sci

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“…arterial phase hyperenhancement followed by late (>60 s) washout of mild degree. 21,22 Nevertheless, CT and MRI are the methods of choice for diagnosing HCC, because they enable examination of the liver as a whole.…”

Section: Diagnosismentioning

confidence: 99%

Comparison of the current international guidelines on the management of HCC

Foerster

Galle

2019

JHEP Reports

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The management of hepatocellular carcinoma (HCC) has become ever more demanding. To evaluate the available evidence and to give clinicians the best guidance, all major hepatology societies have developed guidelines for HCC. Recently, updated versions have been published by the American, the Asian Pacific, and the European societies. This article presents a comparison of these three guidelines summarising both common ground and differences. Moreover, it highlights areas of ongoing research which will make yet another round of updates of the guidelines necessary in the near future.

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“…Practitioners need to be competent in the intravenous administration of contrast agents, be familiar with contraindications and be able to manage any possible adverse effects within the medical and legal framework of their country [4,38]. We refer to the educational activities of the collaborating societies of this paper, the World Federation of Ultrasound in Medicine and Biology (WFUMB) [9,23,[93][94][95][96][97][98][99][100][101][102], the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) [1,3,4,11,37,38,49,50,74,79,[103][104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119] and the CEUS LI-RADS Working Group for Liver Imaging Reporting and Data System (LI-RADS®) [34][35][36][120]…”

Section: Education Qualificationmentioning

confidence: 99%

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2018

Ultrasound Int Open

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American College of Radiology Contrast Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) for the diagnosis of Hepatocellular Carcinoma: a pictorial essay

Cited by 86 publications

References 0 publications

Diagnostic performance of LI-RADS version 2018 in differentiating hepatocellular carcinoma from other hepatic malignancies in patients with hepatitis B virus infection

Diagnostic performance of LI-RADS version 2018 in differentiating hepatocellular carcinoma from other hepatic malignancies in patients with hepatitis B virus infection

Comparison of the current international guidelines on the management of HCC

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