3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study

Bernard, Anne; Addetia, Karima; Dulgheru, Raluca; Caballero, Luis; Sugimoto, Tadafumi; Akhaladze, Natela; Athanassopoulos, George; Barone, Daniele; Baroni, Monica; Cardim, Nuno; Hagendorff, Andreas; Hristová, Krasimira; Ilardi, Federica; López, Teresa; Morena, Gonzalo de la; Popescu, Bogdan A; Pěnička, Martin; Özyiğit, Tolga; Carbonero, D. Rodrigo; Veire, Nico Van de; Bardeleben, Ralph Stephan von; Vinereanu, Dragoş; Zamorano, José Luís; Martinez, Christophe; Magné, Julien; Cosyns, Bernard; Donal, Erwan; Habib, Gilbert; Badano, Luigi P.; Lang, Roberto M.; Lancellotti, Patrizio

doi:10.1093/ehjci/jew284

Cited by 83 publications

(58 citation statements)

References 22 publications

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“…The decrease in LV 3D volumes with age was counterbalanced by an augment in LVEF with advancing age (50,59,95) as occurred also for RV (82). Relationships of left atrial 3D volumes were opposite to the ones observed for the ventricles.…”

Section: D Echocardiographic Parametersmentioning

confidence: 81%

“…In fact, LA 3D volumes increased with age (52,58,81) accompanied by a reduction of LAEF with age (58). LV volumes and mass were higher in men even after normalisation for BSA (51,52,95). The lower volumes in women were counterbalanced by the higher LVEF, however, the stroke volume remained higher in men (51,95).…”

Section: D Echocardiographic Parametersmentioning

confidence: 97%

“…For LV and LA volumes (51,52,58,59,95) the sample size employed was relatively limited for all the studies ranging from 166 (58,59) to 440 (95) healthy subjects. There are sufficient data for 3D RV volumes, particularly those deriving from a study of Maffesanti and colleagues (82), including 507 healthy subjects.…”

Section: D Echocardiographic Parametersmentioning

confidence: 99%

“…Consistencies and discrepancies in the way to measure among authors Data on LV and LA volumes (51,52,58,59,95) have been published by using consistent methodologies. Data on the other measurements are too limited to make comparison.…”

Section: D Echocardiographic Parametersmentioning

confidence: 99%

“…In adults instead fixed rather than subject specific echocardiographic cut-off values have been generally employed for decades to grade disease severity and pose surgical indications (11,12). However, cardiac dimensions and functional indexes change with increasing age also in the adult population and substantially differ according to gender and body size (88)(89)(90)(91)(92)(93)(94)(95)(96). Over the last few years , there has been a crescent call for patients specific rather than generic threshold values , leading multiple authors to publish echocardiographic normative data .…”

Section: Introductionmentioning

confidence: 99%

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Adult echocardiographic nomograms: overview, critical review and creation of a software for automatic, fast and easy calculation of normal values

Cantinotti¹,

Giordano²,

Paterni³

et al. 2017

J. Thorac. Dis.

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There is a crescent interest on normal adult echocardiographic values and the introduction of new deformation imaging and 3D parameters pose the issue of normative data. A multitude of nomograms has been recently published, however data are often fragmentary, difficult to find, and their strengths/ limitations have been never evaluated. Aims: (I) to provide a review of current echocardiographic nomograms; (II) to generate a tool for easy and fast access to these data. A literature search was conducted accessing the National Library of Medicine using the keywords: 2D/3D echocardiography, strain, left/ right ventricle, atrial, mitral/tricuspid valve, aorta, reference values/nomograms/normal values. Adding the following keywords, the results were further refined: range/intervals, myocardial velocity, strain rate and speckle tracking. Forty one published studies were included. Our study reveals that for several of 2D/3D parameters sufficient normative data exist, however, a few limitations still persist. For some basic parameters (i.e., mitral/tricuspid/pulmonary valves, great vessels) and for 3D valves data are scarce. There is a lack of studies evaluating ethnic differences. Data have been generally expressed as mean values normalised for gender and age instead of computing models incorporating different variables (age/gender/body sizes) to calculate z scores. To summarize results a software (Echocardio-Normal Values) who automatically calculate range of normality for a broad range of echocardiographic measurements according to age/gender/weight/ height, has been generated. We provide an up-to-date and critical review of strengths/limitation of current adult echocardiographic nomograms. Furthermore we generated a software for automatic, easy and fast access to multiple echocardiographic normative data.

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Section: D Echocardiographic Parametersmentioning

confidence: 81%

Section: D Echocardiographic Parametersmentioning

confidence: 97%

Section: D Echocardiographic Parametersmentioning

confidence: 99%

Section: D Echocardiographic Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Adult echocardiographic nomograms: overview, critical review and creation of a software for automatic, fast and easy calculation of normal values

Cantinotti¹,

Giordano²,

Paterni³

et al. 2017

J. Thorac. Dis.

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Innovative imaging methods in heart failure: a shifting paradigm in cardiac assessment. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

Čelutkienė

Plymen

Flachskampf

et al. 2018

European J of Heart Fail

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Myriad advances in all fields of cardiac imaging have stimulated and reflected new understanding of cardiac performance, myocardial damage and the mechanisms of heart failure. In this paper, the Heart Failure Association assesses the potential usefulness of innovative imaging modalities in enabling more precise diagnostic and prognostic evaluation, as well as in guiding treatment strategies. Many new methods have gradually penetrated clinical practice and are on their way to becoming a part of routine evaluation. This paper focuses on myocardial deformation and three‐dimensional ultrasound imaging; stress tests for the evaluation of contractile and filling function; the progress of magnetic resonance techniques; molecular imaging and other sound innovations.The Heart Failure Association aims to highlight the ways in which paradigms have shifted in several areas of cardiac assessment. These include reassessing of the simplified concept of ejection fraction and implementation of the new parameters of cardiac performance applicable to all heart failure phenotypes; switching from two‐dimensional to more accurate and reproducible three‐dimensional ultrasound volumetric evaluation; greater tissue characterization via recently developed magnetic resonance modalities; moving from assessing cardiac function and congestion at rest to assessing it during stress; from invasive to novel non‐invasive hybrid techniques depicting coronary anatomy and myocardial perfusion; as well as from morphometry to the imaging of pathophysiologic processes such as inflammation and apoptosis. This position paper examines the specific benefits of imaging innovations for practitioners dealing with heart failure aetiology, risk stratification and monitoring, and, in addition, for scientists involved in the development of future research.

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Normal reference values of left ventricular strain parameters in healthy adults: Real‐life experience from the single‐center three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Healthy Study

Nemes

Kormányos

Kalapos

et al. 2020

J of Clinical Ultrasound

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Introduction: A number of studies defined normal reference values of three-dimensional (3D) speckle-tracking echocardiography (3DSTE)-derived left ventricular (LV) strains. The present study aimed to quantify normal reference values of LV strains in healthy adult population in real clinical world settings in different age groups, and to determine ageand gender-dependence of these variables in a high volume single center. Methods: The present prospective study included 296 healthy adult subjects. Among them, 124 were excluded due to inferior image quality during the 6-year recruitment period (2011-2017). The remaining population was further divided into four subgroups based on age decades. Results: While global radial (RS) strain showed an increase-decrease-increase pattern with age, circumferential, longitudinal, and area strains (CS, LS, AS, respectively) were nonsignificantly lower in older ages. Only global LV-LS showed gender-dependency with higher values in females. Although moderately higher RS and 3DS and lower LS, and AS were observed in males, clear gender-dependency could not be detected in different age decades. Conclusions: This study provides normal reference values of 3DSTE-derived global, segmental, mean segmental, and regional LV strains in healthy adult subjects based on real-life clinical experience. Age-, gender-, and functional nonuniformity of LV strains were also defined.

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3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study

Abstract: The NORRE study provides applicable 3D echocardiographic reference ranges for LV function assessment. Our data highlight the importance of age- and gender-specific reference values for both LV volumes and strain.

Cited by 83 publications

References 22 publications

Adult echocardiographic nomograms: overview, critical review and creation of a software for automatic, fast and easy calculation of normal values

Adult echocardiographic nomograms: overview, critical review and creation of a software for automatic, fast and easy calculation of normal values

Innovative imaging methods in heart failure: a shifting paradigm in cardiac assessment. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

Normal reference values of left ventricular strain parameters in healthy adults: Real‐life experience from the single‐center three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Healthy Study

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