Nanocrystalline cellulose-fullerene: Novel conjugates

Herreros‐López, Ana; Carini, Marco; Ros, Tatiana Da; Carofiglio, Tommaso; Marega, Carla; Parola, Valeria La; Rapozzi, Valentina; Xodo, Luigi E.; Alshatwi, Ali A.; Hadad, Caroline; Prato, Maurizio

doi:10.1016/j.carbpol.2017.01.068

Cited by 20 publications

(15 citation statements)

References 37 publications

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“…In addition, the formation of singlet oxygen, which is needed for photodynamic therapy, decreases after functionalization due to the perturbation of the fullerene π system. These problems can be mitigated by the complexation of fullerenes with water-soluble agents, including nanocellulose [35].…”

Section: Characterization Of Fullerenesmentioning

confidence: 99%

“…In addition, nanocellulose/nanocarbon composites are promising for biomedical applications, though these applications are less frequent than industrial applications. Biomedical applications include radical scavenging [34,92], photothermal ablation of pathogenic bacteria [93], photodynamic and combined chemophotothermal therapy against cancer [35,94], drug delivery [16,28,65,72,[95][96][97], biosensorics [31][32][33]63,66,71,91,[98][99][100][101][102][103][104], and particularly tissue engineering and wound dressings. Hybrid materials containing nanocellulose and nanocarbons stimulated the growth and osteogenic differentiation of human bone marrow mesenchymal stem cells [37,59].…”

Section: Introductionmentioning

confidence: 99%

“…The biomedical applications of nanocellulose/nanocarbon composites are summarized in Table 1. [34]; CNC/C 60 (OH) 30 [92] Photodynamic cancer therapy TEMPO-oxidized CNC/C 60 -NH 2 [35] Photothermal, chemo-photothermal therapy Bacteria: [93] Cancer: [94]…”

Section: Introductionmentioning

confidence: 99%

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Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine

et al. 2020

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Nanocellulose/nanocarbon composites are newly emerging smart hybrid materials containing cellulose nanoparticles, such as nanofibrils and nanocrystals, and carbon nanoparticles, such as “classical” carbon allotropes (fullerenes, graphene, nanotubes and nanodiamonds), or other carbon nanostructures (carbon nanofibers, carbon quantum dots, activated carbon and carbon black). The nanocellulose component acts as a dispersing agent and homogeneously distributes the carbon nanoparticles in an aqueous environment. Nanocellulose/nanocarbon composites can be prepared with many advantageous properties, such as high mechanical strength, flexibility, stretchability, tunable thermal and electrical conductivity, tunable optical transparency, photodynamic and photothermal activity, nanoporous character and high adsorption capacity. They are therefore promising for a wide range of industrial applications, such as energy generation, storage and conversion, water purification, food packaging, construction of fire retardants and shape memory devices. They also hold great promise for biomedical applications, such as radical scavenging, photodynamic and photothermal therapy of tumors and microbial infections, drug delivery, biosensorics, isolation of various biomolecules, electrical stimulation of damaged tissues (e.g., cardiac, neural), neural and bone tissue engineering, engineering of blood vessels and advanced wound dressing, e.g., with antimicrobial and antitumor activity. However, the potential cytotoxicity and immunogenicity of the composites and their components must also be taken into account.

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Section: Characterization Of Fullerenesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine

et al. 2020

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“…This induces cytotoxic effects that lead to an irreversible photodamage of cancer cells [71][72][73][74]77]. In this regard, carbon nanomaterials have been used successfully to cause thermal ablation of solid tumors in breast cancer studies [16,68,[74][75][76][79][80][81][82]. Ogbodu et al [74] reported for the first time the synthesis, photophysical properties, and PDT activity of ZnMCPPc-spermine-SWCNT (zinc monocarboxy phenoxy phthalocyanine upon conjugation to spermidine, as a targeting molecule, and then adsorbed onto SWCNT) on breast cancer cells (MCF-7).…”

Section: Photodynamicmentioning

confidence: 99%

“…Recently, the properties of carbon nanomaterials and their potential applications in PDT have been analyzed in an attempt to substitute current invasive thermal procedures that remove tumors or cancer cells of breast cancer [70][71][72][73][74][75][76][77][78][79][80][81]. Due to the carbon nanomaterials presence in the PDT, cancer cells accumulate light-sensitive molecules (carbon nanomaterials) which, in the presence of oxygen, absorb the radiation of an infrared camera and turn it into heat.…”

Section: Photodynamicmentioning

confidence: 99%

Carbon Nanomaterials for Breast Cancer Treatment

Casais-Molina

Cab

Canto

et al. 2018

Journal of Nanomaterials

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Currently, breast cancer is considered as a health problem worldwide. Furthermore, current treatments neither are capable of stopping its propagation and/or recurrence nor are specific for cancer cells. Therefore, side effects on healthy tissues and cells are common. An increase in the efficiency of treatments, along with a reduction in their toxicity, is desirable to improve the life quality of patients affected by breast cancer. Nanotechnology offers new alternatives for the design and synthesis of nanomaterials that can be used in the identification, diagnosis, and treatment of cancer and has now become a very promising tool for its use against this disease. Among the wide variety of nanomaterials, the scientific community is particularly interested in carbon nanomaterials (fullerenes, nanotubes, and graphene) due to their physical properties, versatile chemical functionalization, and biocompatibility. Recent scientific evidence shows the potential uses of carbon nanomaterials as therapeutic agents, systems for selective and controlled drug release, and contrast agents for diagnosing and locating tumors. This generates new possibilities for the development of innovative systems to treat breast cancer and can be used to detect this disease at much earlier stages. Thus, applications of carbon nanomaterials in breast cancer treatment are discussed in this article.

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