Commentary: Teratogenic effects of the Zika virus and the role of the placenta

Yuan, Shu; Luo, Qin; Zhang, Zhongwei; Li, Zi-Lin

doi:10.3389/fcimb.2017.00062

Cited by 6 publications

(8 citation statements)

References 19 publications

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“…The ZIKV infection in pregnant women can have a significant impact on the growth rate of the fetal brain causing a condition termed microcephaly [80, 81]. It is possible that ZIKV transmits from the mother to the fetus via placenta or the placenta may undergo pathological changes that contribute to developing microcephaly [82, 83]. The primary human placental macrophages (Hofbauer cells) present in the chorionic villi and placental villous fibroblasts accommodate ZIKV and permit virus amplification in placental tissues [84].…”

Section: Zikv Co-infection In Pregnant Women With Human Immunodefimentioning

confidence: 99%

Current concerns and perspectives on Zika virus co-infection with arboviruses and HIV

Rothan

Bidokhti

Byrareddy

2018

Journal of Autoimmunity

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Dissemination of vector-borne viruses, such as Zika virus (ZIKV), in tropical and sub-tropical regions has a complicated impact on the immunopathogenesis of other endemic viruses such as dengue virus (DENV), chikungunya virus (CHIKV) and human immunodeficiency virus (HIV). The consequences of the possible co-infections with these viruses have specifically shown significant impact on the treatment and vaccination strategies. ZIKV is a mosquito-borne flavivirus from African and Asian lineages that causes neurological complications in infected humans. Many of DENV and CHIKV endemic regions have been experiencing outbreaks of ZIKV infection. Intriguingly, the mosquitoes, Aedes Aegypti and Aedes Albopictus, can simultaneously transmit all the combinations of ZIKV, DENV, and CHIKV to the humans. The co-circulation of these viruses leads to a complicated immune response due to the pre-existence or co-existence of ZIKV infection with DENV and CHIKV infections. The non-vector transmission of ZIKV, especially, via sexual intercourse and placenta represents an additional burden that may hander the treatment strategies of other sexually transmitted diseases such as HIV. Collectively, ZIKV co-circulation and co-infection with other viruses have inevitable impact on the host immune response, diagnosis techniques, and vaccine development strategies for the control of these co-infections.

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Section: Zikv Co-infection In Pregnant Women With Human Immunodefimentioning

confidence: 99%

Current concerns and perspectives on Zika virus co-infection with arboviruses and HIV

Rothan

Bidokhti

Byrareddy

2018

Journal of Autoimmunity

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“…If we eliminate ZIKV from the placenta during this window period (i.e., before the virus reaches the fetus), the incidence of congenital abnormalities would be decreased significantly. Interferon therapy, alone or in combination with the drugs that may interfere with the secretory autophagy, can be potentially beneficial for this purpose [8].…”

Section: Vertical Transmission In the Humanmentioning

confidence: 99%

The role of the placenta in prenatally acquired Zika virus infection

Mehrjardi

Shobeirian

2017

VirusDis.

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Zika virus (ZIKV) is an arthropod-borne from the family, which has been recently confirmed to cause severe neurological abnormalities (such as microcephaly, brain parenchymal calcification, hydrocephalus, and malformations of cortical development) in the infected fetuses. The Placenta plays a multifold role in prenatally acquired ZIKV infection. It serves as a port of virus transmission to the fetus, and also can be directly affected by ZIKV leading to a diminished fetal blood supply or a disrupted/changed biological mediators' synthesis. It is crucial to have a detailed knowledge about these pathomechanisms for preventing virus transmission in the infected pregnant women, as well as for prohibiting or reversing placental changes.

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“…As discussed in our previous analysis (Yuan et al, 2017a ), the placental transfer of Zika virus may be a time-consuming process. The virus may take about 5 weeks to reach the fetus (or over 12 weeks, if the infection occurs early in pregnancy).…”

Section: Trehalose May Be An Idea Drug With a High Safetymentioning

confidence: 92%

“…We cannot conclusively claim that the persistence of the virus does not reflect the fetal infection or there is no persistence found in non-pregnant animals (people), as it is possible that Zika virus may persist in immune-privilege cells (Hazlett and Hendricks, 2010 ). However, an analysis of the clinical data implies that the virus may take ~5 weeks to reach the fetus for most cases (Noronha et al, 2016 ; Soares de Souza et al, 2016 ; Yuan et al, 2017a ). Therefore, the virus detected in the pregnant monkey within 35 days of infection is unlikely the backflow from the fetus back into the mother's bloodstream.…”

mentioning

confidence: 99%