Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children

Chen, Y. C.; Chih, An Hsuan; Chen, J. R.; Liou, Tsan Hon; Pan, Wen Harn; Lee, Yungling Leo

doi:10.1038/ijo.2017.67

Cited by 18 publications

(10 citation statements)

References 37 publications

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“…This phenomenon occurred because most children with overweight remain overweight in adulthood. Long‐term fat accumulation may mediate chronic airway obstruction to induce asthma‐like symptoms 37 . In an animal study, chitinase‐3‐like 1 was reported to play a critical role in both visceral fat accumulation and adaptive Th2 immunity 38 .…”

Section: Discussionmentioning

confidence: 99%

Life course body mass index through childhood and young adulthood and risks of asthma and pulmonary function impairment

Chen

Kuo

Hsia

et al. 2021

Pediatric Pulmonology

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Background Adiposity is a key risk factor for asthma and impaired pulmonary function. Objectives We aimed to identify the critical period of life course adiposity for asthma in childhood and young adulthood, and to determine whether associations of adiposity and asthma vary across ages. Methods Birth weight and body mass index (BMI) from birth to 17 years of age were assessed in 6130 children from the Taiwan Children Health Study. Logistic regression for asthma outcome and linear regression for pulmonary function outcome were used to investigate associations of adiposity with asthma. Seventeen BMI‐related single‐nucleotide polymorphisms were used to obtain genetic instrumental variables for adiposity to perform Mendelian randomization (MR) analysis. Results Using both regression model and MR analyses, we confirmed that the critical period of adiposity in predicting childhood asthma would be before age 6 years. Further, we discovered that the sensitive period of adiposity gain related to young adulthood asthma was the prepubertal stage. Risks of asthma at age 17 per unit increase in z‐score of the BMI increased from 0.94 (95% CI: 0.79–1.11) at birth, and became greater than 1.00 between age 11 and 12, then increased to 1.08 (95% CI: 0.95–1.22) at age 17. The associations of life course BMI with asthma and pulmonary function impairment at age 12 and with asthma at age 17 increased with age. The aforementioned association was most prominent among central obesity indicators. Conclusions To prevent asthma in childhood and young adulthood, we should aim at promoting healthy growth at the toddler period and prepubertal stage.

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Section: Discussionmentioning

confidence: 99%

Life course body mass index through childhood and young adulthood and risks of asthma and pulmonary function impairment

Chen

Kuo

Hsia

et al. 2021

Pediatric Pulmonology

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“…In another study, Chen et al. 16 warn of the risk of increased adiposity in the short term, which may increase the incidence or recurrence of symptoms of childhood asthma, besides increased airway inflammation.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Asthma: Impact of the Disease in Children Receiving Outpatient Treatment in Southern Brazil

Roncada

Souza

Costa

et al. 2020

Rev. paul. pediatr.

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Objective: To evaluate the impact of pediatric asthma on patients of a specialized outpatient clinic in Southern Brazil. Methods: The study included children aged 8 to 17 years old with asthma diagnosis (mild, moderate and severe) under treatment at the asthma clinic of Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Brazil. Measurements of spirometry, quality of life, disease control and atopy tests were applied. Results: A total of 66 children were included in the study and divided into groups, according to the severity of the disease: mild, moderate or severe asthma. The results showed similarities in both the treatment and the impact of asthma between groups, except for adherence to treatment: the group with mild asthma showed least adherence to treatment, and the group with severe asthma, greater adherence (p=0.011). As to school absenteeism, the group with severe asthma showed higher frequency (p=0.012), with over 10 days per year (p=0.043). Spirometry showed lower volume/capacity for the group with moderate asthma, followed by the groups with severe and mild asthma. All groups had a high prevalence of allergic asthma, with mites as the main allergens. For quality of life (QOL), and health-related quality of life (HRQOL) levels, there were no differences between groups. In addition, the values were close to the acceptable levels for the total score and for each one of the six domains. The same occurred for the HRQOL-asthma module. Conclusions: QOL and HRQOL present acceptable levels regardless of the severity of the disease.

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“…Obesity is often found in coincidence with asthma, and an “obese asthma” phenotype has been proposed (Novosad, Khan, Wolfe, & Khan, 2013). Furthermore, an association between rapid adiposity growth and risk of new‐onset asthma and airway inflammation has been identified (Chen et al., 2017).…”

Section: Sleep Apnea Asthma and Restrictive Lung Disease In Children With Severe Obesitymentioning

confidence: 99%

Severe paediatric obesity and sleep: A mutual interactive relationship!

Ischander

Lloyd

2020

Journal of Sleep Research

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Achieving and maintaining a healthy weight requires adequate sleep (Sekine et al., 2002;Taheri, 2006). Adequate sleep is a strong weapon for good health in general. Childhood and adolescent severe obesity are associated with serious co-morbidities, including obstructive sleep-disordered breathing (SDB), sleep disturbances, daytime sleepiness, asthma, type 2 diabetes mellitus, hypertension, dyslipidaemia, non-alcoholic fatty liver disease (NAFLD), and even premature death (Kelly et al., 2013). Children growing up in poverty have lower sleep quality and duration, which may lead to childhood obesity (Bagley, Kelly, Buckhalt, & El-Sheikh, 2015). Furthermore, adolescents are at higher risk of insufficient sleep due to a physiological delay in sleep phase plus academic and social demands (Gohil & Hannon, 2018). These childhood problems can complicate adulthood, as severe childhood obesity is associated with adulthood obesity. Additionally, the co-morbidities of severe obesity can have lasting sequelae, such as cardiovascular, metabolic and neurocognitive morbidities (Lo Bue, Salvaggio, & Insalaco, 2020) .Severe obesity was previously defined as body mass index (BMI) > 99th percentile, but more recently it has been defined as BMI ≥ 120% of the 95th percentile as class II and BMI ≥ 140% of the 95th percentile as class III obesity (Skinner, Ravanbakht, Skelton, Perrin, & Armstrong, 2018). Skinner et al. (2018) studied the prevalence of obesity and severe obesity in US children from 1999 to 2016, and reported a significant increase in severe obesity among children aged 2−5 years since the 2013-2014 cycle, a trend that continued upward for many years.

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Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children

Abstract: Obesity-induced asthma could be mediated by high or low airway inflammation, depending on the velocity of increase in adiposity. Rapid adiposity growth may increase risks of childhood asthma and airway inflammation.

Cited by 18 publications

References 37 publications

Life course body mass index through childhood and young adulthood and risks of asthma and pulmonary function impairment

Life course body mass index through childhood and young adulthood and risks of asthma and pulmonary function impairment

Pediatric Asthma: Impact of the Disease in Children Receiving Outpatient Treatment in Southern Brazil

Severe paediatric obesity and sleep: A mutual interactive relationship!

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