The genetics of tiger pelage color variations

Xu, Xiao; Guo, Dong; Schmidt‐Küntzel, Anne; Zhang, Xueli; Zhuang, Yan; Fang, Run; Sun, Xin; Hu, Xuesong; Zhang, Tianyou; Yang, Han-Dong; Zhang, Delu; Marker, Laurie; Jiang, Zhengfan; Li, Ruiqiang; Luo, Shu‐Jin

doi:10.1038/cr.2017.32

Cited by 36 publications

(41 citation statements)

References 8 publications

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“…Golden tigers were homozygous for a CORIN:c.1759C>T variant leading to a histidine to tyrosine change at position 587 [CORIN:p.(His587Tyr)] in the sixth low‐density lipoprotein receptor (LDLR) domain of the protein (Xu et al . 2017). Studies of dirty‐blonde mice and golden tigers enabled Enshell‐Seijffers et al .…”

Section: Discussionmentioning

confidence: 99%

Siberian cats help in solving part of the mystery surrounding golden cats

Beauvois

Citres²,

Gache

et al. 2021

Animal Genetics

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Summary Golden cats have been appreciated since the beginning of the cat fancy. Golden is a modification of the tabby coat. In the Siberian breed, a specific golden phenotype, named sunshine, has been described. Sunshine tabby cats exhibit a warm tone of tabby, a pink nose lacking the black lining and a large light cream area around the nose. Pedigree analyses revealed an autosomal recessive inheritance pattern. A single candidate region was identified by genome‐wide association study (GWAS) and homozygosity mapping. Within that region, we identified CORIN (Corin, serine peptidase) as a strong candidate gene, since CORIN variants have been identified in mice and tigers with a golden phenotype and CORIN has been described as a modifier of the ASIP (Agouti Signaling Protein) pathway. A homozygous CORIN:c.2383C>T missense variant was identified in sunshine tabby cats. Segregation of the variant was consistent with recessive inheritance. The variant was also found in three Kurilian bobtail cats and in two ToyBob cats from the 99 Lives dataset but genotyping of 106 cats from 13 breeds failed to identify carriers in cats from other breeds. The CORIN:c.2383C>T variant was predicted to change an arginine to a cysteine at position 795 in the protein: CORIN:p.(Arg795Cys). Finally, hair observation in Siberian cats was consistent with elongated ASIP signaling as golden hair showed a large yellow band instead of the short subapical one usually observed in agouti hair. These results support an association of the Siberian sunshine modification with the CORIN:c.2383C>T variant. The Siberian cat has helped us to decipher one of the golden phenotypes observed in cats and we propose that the CORIN:c.2383C>T variant represents the wbSIB (Siberian recessive wideband) allele in the domestic cat.

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Section: Discussionmentioning

confidence: 99%

Siberian cats help in solving part of the mystery surrounding golden cats

Beauvois

Citres²,

Gache

et al. 2021

Animal Genetics

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“…Research on wildlife coat color variation is relatively difficult, nevertheless, it covers several contents, including recording (cases reports), behavior/ecological variables (evolutionary), and cellular mechanisms/morphology (developmental) [9]. Research on abnormally-colored tigers (Panthera tigris) (natural polymorphism originated from the wild, captive-maintained) focused on genetic information [75,76], and was not concerned with the influence of coat color variation on their survival and reproduction in wild populations. The inadequacy of monitoring methods and declining wild populations lead to the lack of field data about abnormally-colored wildlife, which makes the research of wildlife coat color variation extremely difficult.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Varied Coat Coloration in a Yellow-Throated Marten (Martes flavigula) Population

Gong¹,

Yang²,

Li³

et al. 2021

Animals

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Mammalian coat color is determined by heritable variations such as disease, nutrition, and hormone levels. Variation in animal coat color is also considered an environmental indicator and provides clues for the study of population genetics and biogeography. Records of abnormal coloration in the wild are rare, not only because it is often selected against, but also because of the difficulties in detection of the phenomenon. We used long-term camera-trapping data to first report abnormal coat coloration in yellow-throated marten (Martes flavigula) in China. Six types of abnormal coloration were found only in the Northeast Tiger and Leopard National Park, Northeast China, which were not reported in other regions in China. A total of 268 videos of Martes flavigula contained normal coloration, 455 videos of individuals of the species contained abnormal coloration, 437 contained the ‘gloving’ type (martens with de-pigmented front toes, paws or lower forelimbs), while the remaining other 18 videos contained five types (different degrees of white-spotting and dilution). The higher relative abundance index (0.428, ‘gloving’ to 0.329, normal) and wide distribution area of the ‘gloving’ type indicated that this abnormal coat coloration type is usual in Northeast China, which may reflect genetic variability in the local population. These records will contribute to further research on animal coat color and its corresponding adaptive strategy.

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“…A missense mutation in the Corin gene of the golden tiger has been recently identified (Xu et al, 2017). This mutation results in the substitution of a histidine residue into tyrosine in the sixth LDLR domain of Corin and therefore does not interfere with its protease activity.…”

Section: To the Editormentioning

confidence: 99%

The Serine Protease Activity of Corin Is Required for Normal Pigment Type Switching

Laron

Aamar

Enshell-Seijffers

2019

Journal of Investigative Dermatology

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is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci 2009;122: 3502e10. Vachtenheim J, Ondrusova L. Microphthalmiaassociated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation. Exp Dermatol 2015;24: 481e4. Wellbrock C, Arozarena I. Microphthalmiaassociated transcription factor in melanoma development and MAP-kinase pathway targeted therapy. Pigment Cell Melanoma Res 2015;28:390e406.

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The genetics of tiger pelage color variations

Cited by 36 publications

References 8 publications

Siberian cats help in solving part of the mystery surrounding golden cats

Siberian cats help in solving part of the mystery surrounding golden cats

Prevalence of Varied Coat Coloration in a Yellow-Throated Marten (Martes flavigula) Population

The Serine Protease Activity of Corin Is Required for Normal Pigment Type Switching

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