“…Consistent with this, recent studies have shown that PARP1‐mediated chromatin modifications affect not only RNAP II elongation but also co‐transcriptional modifications (Matveeva, Al‐Tinawi, Rouchka, & Fondufe‐Mittendorf, ) and that PARP1 is an mRNA‐binding protein (Melikishvili, Chariker, Rouchka, & Fondufe‐Mittendorf, ). Besides, PARP1 binds to and PARylates embryonic lethal abnormal vision‐like 1 (Elavl1)/human antigen R (HuR), allowing its nucleocytoplasmic shuttling and binding to its mRNA targets 3′ ends, increasing their stability (Y. Ke et al, ). Y. Shi et al () also described RBBP6, an E3 ubiquitin ligase originally described to interact with p53 (Simons et al, ), as part of the 3′ end processing molecular architecture.…”